DegronMD

Uniprot ID: B2RTY4

Source protein: Unconventional myosin-IXa

Source gene: MYO9A

Class: DEG_COP1_1

Location: 1307:1315

E3 ligase: COP1

DEGRON score: 0.8455

ASA_SCORE: 85.2111

COIL: 0.7992

CONS_SCORE: 0.3416

DSS_SCORE: 0.6227

HELIX: 0.1244

FCONS_SCORE: 0.9663

RIG_SCORE: 0.7032

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1300S	TCGA-05-5425	LUAD	TCGA	STELVPEGL	DEG_COP1_1	0.1389
p.P1300S	TCGA-EB-A3Y7	SKCM	TCGA	STELVPEGL	DEG_COP1_1	0.1389
p.P1300S	TCGA-EB-A5UM	SKCM	TCGA	STELVPEGL	DEG_COP1_1	0.1389
p.P1300S	TCGA-EE-A3AB	SKCM	TCGA	STELVPEGL	DEG_COP1_1	0.1389
p.R1304C	TCGA-AP-A0LM	UCEC	TCGA	STELVPEGL	DEG_COP1_1	0.25
p.R1304C	TCGA-CA-6717	COAD	TCGA	STELVPEGL	DEG_COP1_1	0.25
p.P1300L	TCGA-WE-A8ZN	SKCM	TCGA	STELVPEGL	DEG_COP1_1	0.1389
p.P1300L	ACH-001329	Brain Cancer	CCLE	STELVPEGL	DEG_COP1_1	0.1389
p.L1325V	DO48547	STAD	ICGC	STELVPEGL	DEG_COP1_1	0.0556
p.L1314P	DO48547	STAD	ICGC	STELVPEGL	DEG_COP1_1	0.7582
p.R1319Q	SIDM00433	T-Lymphoblastic Leukemia	GDSC	STELVPEGL	DEG_COP1_1	0.2222
p.R1319Q	ACH-000795	Leukemia	CCLE	STELVPEGL	DEG_COP1_1	0.2222
p.R1319Q	MOLT-13	haematopoietic_and_lymphoid_tissue	COSMIC	STELVPEGL	DEG_COP1_1	0.2222
p.D1323H	SIDM00472	Ovarian Carcinoma	GDSC	STELVPEGL	DEG_COP1_1	0.1111
p.D1323H	ACH-001630	Ovarian Cancer	CCLE	STELVPEGL	DEG_COP1_1	0.1111
p.D1323H	ACH-001632	Ovarian Cancer	CCLE	STELVPEGL	DEG_COP1_1	0.1111
p.D1323H	PEO1	ovary	COSMIC	STELVPEGL	DEG_COP1_1	0.1111
p.R1319W	SIDM00244	Neuroblastoma	GDSC	STELVPEGL	DEG_COP1_1	0.2222
p.R1319W	NB69	autonomic_ganglia	COSMIC	STELVPEGL	DEG_COP1_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
B2RTY4	Unconventional myosin-IXa	DEG_COP1_1	1307:1315	STELVPEGL	COP1	0.8455	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons