DegronMD

Uniprot ID: B2RTY4

Source protein: Unconventional myosin-IXa

Source gene: MYO9A

Class: DEG_SCF_FBW7_1

Location: 1806:1811

E3 ligase: FBXW7

DEGRON score: 0.9982

ASA_SCORE: 63.6

COIL: 0.9693

CONS_SCORE: 0.404

DSS_SCORE: 0.5891

HELIX: 0.0158

FCONS_SCORE: 1.2972

RIG_SCORE: 0.6289

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1798S	TCGA-IH-A3EA	SKCM	TCGA	PTPPLS	DEG_SCF_FBW7_1	0.1111
p.G1816C	TCGA-NJ-A4YQ	LUAD	TCGA	PTPPLS	DEG_SCF_FBW7_1	0.1944
p.Q1796E	TCGA-XF-A9SH	BLCA	TCGA	PTPPLS	DEG_SCF_FBW7_1	0.0556
p.R1815C	DO1221	BRCA	ICGC	PTPPLS	DEG_SCF_FBW7_1	0.2222
p.R1817Q	DO222798	COCA	ICGC	PTPPLS	DEG_SCF_FBW7_1	0.1667
p.S1810C	DO234369	ESAD	ICGC	PTPPLS	DEG_SCF_FBW7_1	0.7541
p.K1816R	DO233230	GACA	ICGC	PTPPLS	DEG_SCF_FBW7_1	0.1944
p.R1815S	DO228952	LICA	ICGC	PTPPLS	DEG_SCF_FBW7_1	0.2222
p.R1815S	DO229018	LICA	ICGC	PTPPLS	DEG_SCF_FBW7_1	0.2222
p.F1803L	DO229034	LICA	ICGC	PTPPLS	DEG_SCF_FBW7_1	0.25
p.G1797C	DO218944	LUAD	ICGC	PTPPLS	DEG_SCF_FBW7_1	0.0833
p.F1803C	DO29920	OV	ICGC	PTPPLS	DEG_SCF_FBW7_1	0.25
p.P1811S	DO47274	SKCM	ICGC	PTPPLS	DEG_SCF_FBW7_1	0.6752
p.R1815H	DO41235	UCEC	ICGC	PTPPLS	DEG_SCF_FBW7_1	0.2222
p.R1819W	SIDM00958	Chronic Myelogenous Leukemia	GDSC	PTPPLS	DEG_SCF_FBW7_1	0.1111
p.R1819W	ACH-000920	Leukemia	CCLE	PTPPLS	DEG_SCF_FBW7_1	0.1111
p.R1819W	ACH-001495	Endometrial/Uterine Cancer	CCLE	PTPPLS	DEG_SCF_FBW7_1	0.1111
p.R1819W	CML-T1	haematopoietic_and_lymphoid_tissue	COSMIC	PTPPLS	DEG_SCF_FBW7_1	0.1111
p.G1816S	SIDM00922	Non-Small Cell Lung Carcinoma	GDSC	PTPPLS	DEG_SCF_FBW7_1	0.1944
p.G1816S	ACH-000392	Lung Cancer	CCLE	PTPPLS	DEG_SCF_FBW7_1	0.1944
p.G1816S	Calu-3	lung	COSMIC	PTPPLS	DEG_SCF_FBW7_1	0.1944
p.A1803V	ACH-000960	Leukemia	CCLE	PTPPLS	DEG_SCF_FBW7_1	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons