DegronMD

Uniprot ID: Q9GZR1

Source protein: Sentrin-specific protease 6

Source gene: SENP6

Class: DEG_SCF_FBW7_1

Location: 216:221

E3 ligase: FBXW7

DEGRON score: 0.9982

ASA_SCORE: 88.85

COIL: 0.97

CONS_SCORE: 0.2898

DSS_SCORE: 0.5262

HELIX: 0.016

FCONS_SCORE: 0.9816

RIG_SCORE: 0.6345

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S212N	TCGA-A5-A0G2	UCEC	TCGA	PTPPLS	DEG_SCF_FBW7_1	0.2222
p.H210Y	TCGA-B5-A3FA	UCEC	TCGA	PTPPLS	DEG_SCF_FBW7_1	0.1667
p.R209L	TCGA-D3-A2JN	SKCM	TCGA	PTPPLS	DEG_SCF_FBW7_1	0.1389
p.D226Y	DO223046	ESCA	ICGC	PTPPLS	DEG_SCF_FBW7_1	0.6389
p.Q208K	DO233852	GACA	ICGC	PTPPLS	DEG_SCF_FBW7_1	0.2222
p.L224F	DO228297	LICA	ICGC	PTPPLS	DEG_SCF_FBW7_1	0.6944
p.Q208H	DO228948	LICA	ICGC	PTPPLS	DEG_SCF_FBW7_1	0.2222
p.C220F	DO229029	LICA	ICGC	PTPPLS	DEG_SCF_FBW7_1	0.7108
p.F230V	DO36556	READ	ICGC	PTPPLS	DEG_SCF_FBW7_1	0.0833
p.R229I	DO42312	UCEC	ICGC	PTPPLS	DEG_SCF_FBW7_1	0.1111
p.Q206R	SIDM00433	T-Lymphoblastic Leukemia	GDSC	PTPPLS	DEG_SCF_FBW7_1	0.0556
p.Q206R	SIDM01000	Melanoma	GDSC	PTPPLS	DEG_SCF_FBW7_1	0.0556
p.R209Q	SIDM00500	Colorectal Carcinoma	GDSC	PTPPLS	DEG_SCF_FBW7_1	0.1389
p.R209Q	ACH-000959	Colon/Colorectal Cancer	CCLE	PTPPLS	DEG_SCF_FBW7_1	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons