DegronMD - Q9GZR1(SENP6)

SENP6

Please click HERE for better display.

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S212N	TCGA-A5-A0G2	UCEC	TCGA	PTPPLS	DEG_SCF_FBW7_1	216:221	Mutation rewiring degron network	0.2222
p.H210Y	TCGA-B5-A3FA	UCEC	TCGA	PTPPLS	DEG_SCF_FBW7_1	216:221	Mutation rewiring degron network	0.1667
p.R209L	TCGA-D3-A2JN	SKCM	TCGA	PTPPLS	DEG_SCF_FBW7_1	216:221	Mutation rewiring degron network	0.1389
p.D226Y	DO223046	ESCA	ICGC	PTPPLS	DEG_SCF_FBW7_1	216:221	Mutation blocking ubiquitination signal	0.6389
p.Q208K	DO233852	GACA	ICGC	PTPPLS	DEG_SCF_FBW7_1	216:221	Mutation substituting flanking lysine	0.2222
p.L224F	DO228297	LICA	ICGC	PTPPLS	DEG_SCF_FBW7_1	216:221	Mutation blocking phosphorylation signal	0.6944
p.Q208H	DO228948	LICA	ICGC	PTPPLS	DEG_SCF_FBW7_1	216:221	Mutation substituting flanking lysine	0.2222
p.C220F	DO229029	LICA	ICGC	PTPPLS	DEG_SCF_FBW7_1	216:221	Mutation altering degron motif	0.7108
p.F230V	DO36556	READ	ICGC	PTPPLS	DEG_SCF_FBW7_1	216:221	Mutation rewiring degron network	0.0833
p.R229I	DO42312	UCEC	ICGC	PTPPLS	DEG_SCF_FBW7_1	216:221	Mutation rewiring degron network	0.1111
p.Q206R	SIDM00433	T-Lymphoblastic Leukemia	GDSC	PTPPLS	DEG_SCF_FBW7_1	216:221	Mutation rewiring degron network	0.0556
p.Q206R	SIDM01000	Melanoma	GDSC	PTPPLS	DEG_SCF_FBW7_1	216:221	Mutation rewiring degron network	0.0556
p.R209Q	SIDM00500	Colorectal Carcinoma	GDSC	PTPPLS	DEG_SCF_FBW7_1	216:221	Mutation rewiring degron network	0.1389
p.R209Q	ACH-000959	Colon/Colorectal Cancer	CCLE	PTPPLS	DEG_SCF_FBW7_1	216:221	Mutation rewiring degron network	0.1389

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc