DegronMD

Uniprot ID: B2RTY4

Source protein: Unconventional myosin-IXa

Source gene: MYO9A

Class: DEG_APCC_DBOX_1

Location: 774:782

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9078

ASA_SCORE: 67.0667

COIL: 0.6239

CONS_SCORE: 0.3214

DSS_SCORE: 0.5573

HELIX: 0.2911

FCONS_SCORE: 1.1039

RIG_SCORE: 0.7253

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R771Q	TCGA-2Y-A9H9	LIHC	TCGA	PRTPLSDLQ	DEG_APCC_DBOX_1	0.25
p.N791K	TCGA-AG-A002	READ	TCGA	PRTPLSDLQ	DEG_APCC_DBOX_1	0.0833
p.N791K	TCGA-EI-6917	READ	TCGA	PRTPLSDLQ	DEG_APCC_DBOX_1	0.0833
p.I769V	TCGA-DI-A1BU	UCEC	TCGA	PRTPLSDLQ	DEG_APCC_DBOX_1	0.1944
p.S779C	TCGA-DR-A0ZM	CESC	TCGA	PRTPLSDLQ	DEG_APCC_DBOX_1	0.643
p.Q773K	DO229018	LICA	ICGC	PRTPLSDLQ	DEG_APCC_DBOX_1	0.3056
p.N772K	DO36881	READ	ICGC	PRTPLSDLQ	DEG_APCC_DBOX_1	0.2778
p.R788C	DO37951	SKCM	ICGC	PRTPLSDLQ	DEG_APCC_DBOX_1	0.1667
p.I787V	DO47953	STAD	ICGC	PRTPLSDLQ	DEG_APCC_DBOX_1	0.1944
p.E770K	DO229268	THCA	ICGC	PRTPLSDLQ	DEG_APCC_DBOX_1	0.2222
p.R775T	SIDM00501	Oral Cavity Carcinoma	GDSC	PRTPLSDLQ	DEG_APCC_DBOX_1	0.7876
p.R775T	ACH-001332	Head and Neck Cancer	CCLE	PRTPLSDLQ	DEG_APCC_DBOX_1	0.7876
p.R775T	BICR78	upper_aerodigestive_tract	COSMIC	PRTPLSDLQ	DEG_APCC_DBOX_1	0.7876
p.M784L	SIDM00105	Ovarian Carcinoma	GDSC	PRTPLSDLQ	DEG_APCC_DBOX_1	0.2778
p.M784L	OVCAR-3	ovary	COSMIC	PRTPLSDLQ	DEG_APCC_DBOX_1	0.2778
p.A786S	SIDM00145	T-Lymphoblastic Leukemia	GDSC	PRTPLSDLQ	DEG_APCC_DBOX_1	0.2222
p.A786S	ACH-001127	Leukemia	CCLE	PRTPLSDLQ	DEG_APCC_DBOX_1	0.2222
p.A786S	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	PRTPLSDLQ	DEG_APCC_DBOX_1	0.2222
p.N773I	SIDM00638	Cervical Carcinoma	GDSC	PRTPLSDLQ	DEG_APCC_DBOX_1	0.3056
p.N773I	ACH-001360	Cervical Cancer	CCLE	PRTPLSDLQ	DEG_APCC_DBOX_1	0.3056
p.N773I	MS751	cervix	COSMIC	PRTPLSDLQ	DEG_APCC_DBOX_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
B2RTY4	Unconventional myosin-IXa	DEG_APCC_DBOX_1	774:782	PRTPLSDLQ	APC,CDC20,FZR1	0.9078	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons