DegronMD

Uniprot ID: B2RTY4

Source protein: Unconventional myosin-IXa

Source gene: MYO9A

Class: DEG_APCC_KENBOX_2

Location: 1822:1826

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9931

ASA_SCORE: 121.18

COIL: 0.7202

CONS_SCORE: 0.393

DSS_SCORE: 0.6429

HELIX: 0.2546

FCONS_SCORE: 1.0993

RIG_SCORE: 0.662

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F1822C	TCGA-24-1845	OV	TCGA	FKENK	DEG_APCC_KENBOX_2	0.5996
p.R1834H	TCGA-A5-A0G2	UCEC	TCGA	FKENK	DEG_APCC_KENBOX_2	0.1111
p.R1834H	SIDM02050	Colorectal Carcinoma	GDSC	FKENK	DEG_APCC_KENBOX_2	0.1111
p.R1834H	SIDM00223	Small Cell Lung Carcinoma	GDSC	FKENK	DEG_APCC_KENBOX_2	0.1111
p.R1834H	ACH-002144	Lung Cancer	CCLE	FKENK	DEG_APCC_KENBOX_2	0.1111
p.R1834H	IST-SL1	lung	COSMIC	FKENK	DEG_APCC_KENBOX_2	0.1111
p.P1830S	TCGA-D3-A51N	SKCM	TCGA	FKENK	DEG_APCC_KENBOX_2	0.2222
p.G1816C	TCGA-NJ-A4YQ	LUAD	TCGA	FKENK	DEG_APCC_KENBOX_2	0.1667
p.R1815C	DO1221	BRCA	ICGC	FKENK	DEG_APCC_KENBOX_2	0.1389
p.R1817Q	DO222798	COCA	ICGC	FKENK	DEG_APCC_KENBOX_2	0.1944
p.K1816R	DO233230	GACA	ICGC	FKENK	DEG_APCC_KENBOX_2	0.1667
p.H1830N	DO228948	LICA	ICGC	FKENK	DEG_APCC_KENBOX_2	0.2222
p.R1815S	DO228952	LICA	ICGC	FKENK	DEG_APCC_KENBOX_2	0.1389
p.R1815S	DO229018	LICA	ICGC	FKENK	DEG_APCC_KENBOX_2	0.1389
p.R1815H	DO41235	UCEC	ICGC	FKENK	DEG_APCC_KENBOX_2	0.1389
p.R1819W	SIDM00958	Chronic Myelogenous Leukemia	GDSC	FKENK	DEG_APCC_KENBOX_2	0.25
p.R1819W	ACH-000920	Leukemia	CCLE	FKENK	DEG_APCC_KENBOX_2	0.25
p.R1819W	ACH-001495	Endometrial/Uterine Cancer	CCLE	FKENK	DEG_APCC_KENBOX_2	0.25
p.R1819W	CML-T1	haematopoietic_and_lymphoid_tissue	COSMIC	FKENK	DEG_APCC_KENBOX_2	0.25
p.G1816S	SIDM00922	Non-Small Cell Lung Carcinoma	GDSC	FKENK	DEG_APCC_KENBOX_2	0.1667
p.G1816S	ACH-000392	Lung Cancer	CCLE	FKENK	DEG_APCC_KENBOX_2	0.1667
p.G1816S	Calu-3	lung	COSMIC	FKENK	DEG_APCC_KENBOX_2	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons