DegronMD

Uniprot ID: O60422

Source protein: One cut domain family member 3

Source gene: ONECUT3

Class: DEG_APCC_KENBOX_2

Location: 433:437

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7388

ASA_SCORE: 105.9

COIL: 0.5954

CONS_SCORE: 0.8431

DSS_SCORE: 0.3682

HELIX: 0.4056

FCONS_SCORE: 1.0691

RIG_SCORE: 0.8007

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T446A	TCGA-B5-A1MX	UCEC	TCGA	FKENK	DEG_APCC_KENBOX_2	0.0833
p.T446A	DO41999	UCEC	ICGC	FKENK	DEG_APCC_KENBOX_2	0.0833
p.R427H	TCGA-CM-4746	COAD	TCGA	FKENK	DEG_APCC_KENBOX_2	0.1667
p.R427H	DO7882	COAD	ICGC	FKENK	DEG_APCC_KENBOX_2	0.1667
p.I430V	TCGA-WZ-A8D5	TGCT	TCGA	FKENK	DEG_APCC_KENBOX_2	0.25
p.M443K	DO228926	LICA	ICGC	FKENK	DEG_APCC_KENBOX_2	0.1667
p.F433L	DO50720	ORCA	ICGC	FKENK	DEG_APCC_KENBOX_2	0.587
p.V445I	DO232519	PBCA	ICGC	FKENK	DEG_APCC_KENBOX_2	0.1111
p.T428M	DO229264	THCA	ICGC	FKENK	DEG_APCC_KENBOX_2	0.1944
p.R438Q	DO229216	THCA	ICGC	FKENK	DEG_APCC_KENBOX_2	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons