DegronMD

Uniprot ID: O95948

Source protein: One cut domain family member 2

Source gene: ONECUT2

Class: DEG_APCC_KENBOX_2

Location: 445:449

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6465

ASA_SCORE: 99.6

COIL: 0.5948

CONS_SCORE: 0.8668

DSS_SCORE: 0.3892

HELIX: 0.4016

FCONS_SCORE: 1.0409

RIG_SCORE: 0.8096

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R438C	TCGA-61-2012	OV	TCGA	FKENK	DEG_APCC_KENBOX_2	0.1389
p.R438C	TCGA-BR-7901	STAD	TCGA	FKENK	DEG_APCC_KENBOX_2	0.1389
p.R438C	TCGA-ZF-AA4W	BLCA	TCGA	FKENK	DEG_APCC_KENBOX_2	0.1389
p.R438C	DO219089	BLCA	ICGC	FKENK	DEG_APCC_KENBOX_2	0.1389
p.R438C	DO32536	OV	ICGC	FKENK	DEG_APCC_KENBOX_2	0.1389
p.R438C	DO38463	STAD	ICGC	FKENK	DEG_APCC_KENBOX_2	0.1389
p.D435Y	TCGA-61-2113	OV	TCGA	FKENK	DEG_APCC_KENBOX_2	0.0556
p.D435Y	DO29328	OV	ICGC	FKENK	DEG_APCC_KENBOX_2	0.0556
p.I444M	TCGA-64-1677	LUAD	TCGA	FKENK	DEG_APCC_KENBOX_2	0.3056
p.I444M	DO23996	LUAD	ICGC	FKENK	DEG_APCC_KENBOX_2	0.3056
p.L436P	TCGA-A6-A565	COAD	TCGA	FKENK	DEG_APCC_KENBOX_2	0.0833
p.L436P	DO44090	COAD	ICGC	FKENK	DEG_APCC_KENBOX_2	0.0833
p.K446E	TCGA-B5-A0K6	UCEC	TCGA	FKENK	DEG_APCC_KENBOX_2	0.7022
p.K446E	DO40808	UCEC	ICGC	FKENK	DEG_APCC_KENBOX_2	0.7022
p.R450C	TCGA-CM-6162	COAD	TCGA	FKENK	DEG_APCC_KENBOX_2	0.3056
p.R450C	DO8479	COAD	ICGC	FKENK	DEG_APCC_KENBOX_2	0.3056
p.R450C	SIDM00645	Non-Small Cell Lung Carcinoma	GDSC	FKENK	DEG_APCC_KENBOX_2	0.3056
p.R450C	ACH-000666	Lung Cancer	CCLE	FKENK	DEG_APCC_KENBOX_2	0.3056
p.R450C	NCI-H1355	lung	COSMIC	FKENK	DEG_APCC_KENBOX_2	0.3056
p.F442S	TCGA-D1-A17Q	UCEC	TCGA	FKENK	DEG_APCC_KENBOX_2	0.25
p.F442S	DO41903	UCEC	ICGC	FKENK	DEG_APCC_KENBOX_2	0.25
p.E454K	TCGA-DA-A960	SKCM	TCGA	FKENK	DEG_APCC_KENBOX_2	0.1944
p.E454K	DO222521	MELA	ICGC	FKENK	DEG_APCC_KENBOX_2	0.1944
p.E454K	DO222653	MELA	ICGC	FKENK	DEG_APCC_KENBOX_2	0.1944
p.E454K	DO219482	SKCM	ICGC	FKENK	DEG_APCC_KENBOX_2	0.1944
p.L441I	TCGA-EO-A22R	UCEC	TCGA	FKENK	DEG_APCC_KENBOX_2	0.2222
p.L441I	DO42713	UCEC	ICGC	FKENK	DEG_APCC_KENBOX_2	0.2222
p.E447K	TCGA-ER-A42L	SKCM	TCGA	FKENK	DEG_APCC_KENBOX_2	0.7022
p.E447K	DO220879	MELA	ICGC	FKENK	DEG_APCC_KENBOX_2	0.7022
p.E447K	DO223910	SKCM	ICGC	FKENK	DEG_APCC_KENBOX_2	0.7022
p.R439Q	DO222960	BTCA	ICGC	FKENK	DEG_APCC_KENBOX_2	0.1667
p.A443T	DO230336	COCA	ICGC	FKENK	DEG_APCC_KENBOX_2	0.2778
p.A443S	DO228986	LICA	ICGC	FKENK	DEG_APCC_KENBOX_2	0.2778
p.T440R	DO44792	LICA	ICGC	FKENK	DEG_APCC_KENBOX_2	0.1944
p.S452L	DO222837	MELA	ICGC	FKENK	DEG_APCC_KENBOX_2	0.25
p.P451L	DO232224	PBCA	ICGC	FKENK	DEG_APCC_KENBOX_2	0.2778
p.K449E	DO229446	SKCA	ICGC	FKENK	DEG_APCC_KENBOX_2	0.591

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
B2RTY4	Unconventional myosin-IXa	DEG_APCC_KENBOX_2	1822:1826	FKENK	APC,CDC20,FZR1	0.9931	More...
O95948	One cut domain family member 2	DEG_APCC_KENBOX_2	445:449	FKENK	APC,CDC20,FZR1	0.6465	More...
Q9UBC0	Hepatocyte nuclear factor 6	DEG_APCC_KENBOX_2	404:408	FKENK	APC,CDC20,FZR1	0.7531	More...
O60422	One cut domain family member 3	DEG_APCC_KENBOX_2	433:437	FKENK	APC,CDC20,FZR1	0.7388	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: FKENK

Degron related mutations and impact score

Drug responses associated with ONECUT2 mutations

All proteins holding degron of FKENK