DegronMD - O95948(ONECUT2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G328D	TCGA-06-5416	GBM	TCGA	PPSSS	DEG_SPOP_SBC_1	315:319	Mutation rewiring degron network	0.0833
p.G328D	DO10880	GBM	ICGC	PPSSS	DEG_SPOP_SBC_1	315:319	Mutation rewiring degron network	0.0833
p.R438C	TCGA-61-2012	OV	TCGA	FKENK	DEG_APCC_KENBOX_2	445:449	Mutation rewiring degron network	0.1389
p.R438C	TCGA-BR-7901	STAD	TCGA	FKENK	DEG_APCC_KENBOX_2	445:449	Mutation rewiring degron network	0.1389
p.R438C	TCGA-ZF-AA4W	BLCA	TCGA	FKENK	DEG_APCC_KENBOX_2	445:449	Mutation rewiring degron network	0.1389
p.R438C	DO219089	BLCA	ICGC	FKENK	DEG_APCC_KENBOX_2	445:449	Mutation rewiring degron network	0.1389
p.R438C	DO32536	OV	ICGC	FKENK	DEG_APCC_KENBOX_2	445:449	Mutation rewiring degron network	0.1389
p.R438C	DO38463	STAD	ICGC	FKENK	DEG_APCC_KENBOX_2	445:449	Mutation rewiring degron network	0.1389
p.D435Y	TCGA-61-2113	OV	TCGA	FKENK	DEG_APCC_KENBOX_2	445:449	Mutation rewiring degron network	0.0556
p.D435Y	DO29328	OV	ICGC	FKENK	DEG_APCC_KENBOX_2	445:449	Mutation rewiring degron network	0.0556
p.I444M	TCGA-64-1677	LUAD	TCGA	FKENK	DEG_APCC_KENBOX_2	445:449	Mutation rewiring degron network	0.3056
p.I444M	DO23996	LUAD	ICGC	FKENK	DEG_APCC_KENBOX_2	445:449	Mutation rewiring degron network	0.3056
p.L436P	TCGA-A6-A565	COAD	TCGA	FKENK	DEG_APCC_KENBOX_2	445:449	Mutation rewiring degron network	0.0833
p.L436P	DO44090	COAD	ICGC	FKENK	DEG_APCC_KENBOX_2	445:449	Mutation rewiring degron network	0.0833
p.S320L	TCGA-AP-A059	UCEC	TCGA	PPSSS	DEG_SPOP_SBC_1	315:319	Mutation rewiring degron network	0.3056
p.S320L	DO41361	UCEC	ICGC	PPSSS	DEG_SPOP_SBC_1	315:319	Mutation rewiring degron network	0.3056
p.K446E	TCGA-B5-A0K6	UCEC	TCGA	FKENK	DEG_APCC_KENBOX_2	445:449	Mutation altering degron motif	0.7022
p.K446E	DO40808	UCEC	ICGC	FKENK	DEG_APCC_KENBOX_2	445:449	Mutation altering degron motif	0.7022
p.R450C	TCGA-CM-6162	COAD	TCGA	FKENK	DEG_APCC_KENBOX_2	445:449	Mutation rewiring degron network	0.3056
p.R450C	DO8479	COAD	ICGC	FKENK	DEG_APCC_KENBOX_2	445:449	Mutation rewiring degron network	0.3056
p.R450C	SIDM00645	Non-Small Cell Lung Carcinoma	GDSC	FKENK	DEG_APCC_KENBOX_2	445:449	Mutation rewiring degron network	0.3056
p.R450C	ACH-000666	Lung Cancer	CCLE	FKENK	DEG_APCC_KENBOX_2	445:449	Mutation rewiring degron network	0.3056
p.R450C	NCI-H1355	lung	COSMIC	FKENK	DEG_APCC_KENBOX_2	445:449	Mutation rewiring degron network	0.3056
p.E122Q	TCGA-CV-A45W	HNSC	TCGA	DYR	CBL_MET	118:120	Mutation rewiring degron network	0.2778
p.E122Q	DO52060	HNSC	ICGC	DYR	CBL_MET	118:120	Mutation rewiring degron network	0.2778
p.F442S	TCGA-D1-A17Q	UCEC	TCGA	FKENK	DEG_APCC_KENBOX_2	445:449	Mutation rewiring degron network	0.25
p.F442S	DO41903	UCEC	ICGC	FKENK	DEG_APCC_KENBOX_2	445:449	Mutation rewiring degron network	0.25
p.E454K	TCGA-DA-A960	SKCM	TCGA	FKENK	DEG_APCC_KENBOX_2	445:449	Mutation rewiring degron network	0.1944
p.E454K	DO222521	MELA	ICGC	FKENK	DEG_APCC_KENBOX_2	445:449	Mutation rewiring degron network	0.1944
p.E454K	DO222653	MELA	ICGC	FKENK	DEG_APCC_KENBOX_2	445:449	Mutation rewiring degron network	0.1944
p.E454K	DO219482	SKCM	ICGC	FKENK	DEG_APCC_KENBOX_2	445:449	Mutation rewiring degron network	0.1944
p.L441I	TCGA-EO-A22R	UCEC	TCGA	FKENK	DEG_APCC_KENBOX_2	445:449	Mutation rewiring degron network	0.2222
p.L441I	DO42713	UCEC	ICGC	FKENK	DEG_APCC_KENBOX_2	445:449	Mutation rewiring degron network	0.2222
p.E447K	TCGA-ER-A42L	SKCM	TCGA	FKENK	DEG_APCC_KENBOX_2	445:449	Mutation altering degron motif	0.7022
p.E447K	DO220879	MELA	ICGC	FKENK	DEG_APCC_KENBOX_2	445:449	Mutation altering degron motif	0.7022
p.E447K	DO223910	SKCM	ICGC	FKENK	DEG_APCC_KENBOX_2	445:449	Mutation altering degron motif	0.7022
p.M110I	TCGA-R5-A7ZI	STAD	TCGA	DYR	CBL_MET	118:120	Mutation rewiring degron network	0.1111
p.M110I	DO222342	STAD	ICGC	DYR	CBL_MET	118:120	Mutation rewiring degron network	0.1111
p.R439Q	DO222960	BTCA	ICGC	FKENK	DEG_APCC_KENBOX_2	445:449	Mutation rewiring degron network	0.1667
p.A443T	DO230336	COCA	ICGC	FKENK	DEG_APCC_KENBOX_2	445:449	Mutation rewiring degron network	0.2778
p.S317L	DO233731	GACA	ICGC	PPSSS	DEG_SPOP_SBC_1	315:319	Mutation altering degron motif	0.7667
p.A443S	DO228986	LICA	ICGC	FKENK	DEG_APCC_KENBOX_2	445:449	Mutation rewiring degron network	0.2778
p.Q329H	DO229037	LICA	ICGC	PPSSS	DEG_SPOP_SBC_1	315:319	Mutation rewiring degron network	0.0556
p.T440R	DO44792	LICA	ICGC	FKENK	DEG_APCC_KENBOX_2	445:449	Mutation rewiring degron network	0.1944
p.S124F	DO220875	MELA	ICGC	DYR	CBL_MET	118:120	Mutation rewiring degron network	0.2222
p.S452L	DO222837	MELA	ICGC	FKENK	DEG_APCC_KENBOX_2	445:449	Mutation rewiring degron network	0.25
p.P451L	DO232224	PBCA	ICGC	FKENK	DEG_APCC_KENBOX_2	445:449	Mutation rewiring degron network	0.2778
p.K449E	DO229446	SKCA	ICGC	FKENK	DEG_APCC_KENBOX_2	445:449	Mutation altering degron motif	0.591
p.H129Q	ACH-002005	Skin Cancer	CCLE	DYR	CBL_MET	118:120	Mutation rewiring degron network	0.0833

Kaplan plot for ONECUT2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ONECUT2

UniProt ID: O95948

Entrez ID: 9480

Protein name: One cut domain family member 2 (Hepatocyte nuclear factor 6-beta) (HNF-6-beta) (One cut homeobox 2) (Transcription factor ONECUT-2) (OC-2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ONECUT2 in