DegronMD

Uniprot ID: Q9UBC0

Source protein: Hepatocyte nuclear factor 6

Source gene: ONECUT1

Class: DEG_CRL4_CDT2_1

Location: 427:440

E3 ligase: DTL

DEGRON score: 0.5893

ASA_SCORE: 61.9214

COIL: 0.3389

CONS_SCORE: 0.8814

DSS_SCORE: 0.324

HELIX: 0.5469

FCONS_SCORE: 1.1832

RIG_SCORE: 0.8142

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D446Y	TCGA-A5-A0G9	UCEC	TCGA	STVSNFFMNARRRS	DEG_CRL4_CDT2_1	0.1667
p.D446Y	DO42304	UCEC	ICGC	STVSNFFMNARRRS	DEG_CRL4_CDT2_1	0.1667
p.S449N	TCGA-D1-A15X	UCEC	TCGA	STVSNFFMNARRRS	DEG_CRL4_CDT2_1	0.0833
p.S449N	DO43274	UCEC	ICGC	STVSNFFMNARRRS	DEG_CRL4_CDT2_1	0.0833
p.K443R	TCGA-DI-A1BU	UCEC	TCGA	STVSNFFMNARRRS	DEG_CRL4_CDT2_1	0.3611
p.K443R	DO42023	UCEC	ICGC	STVSNFFMNARRRS	DEG_CRL4_CDT2_1	0.3611
p.T417A	TCGA-DI-A1BU	UCEC	TCGA	STVSNFFMNARRRS	DEG_CRL4_CDT2_1	0.0556
p.T417A	DO42023	UCEC	ICGC	STVSNFFMNARRRS	DEG_CRL4_CDT2_1	0.0556
p.D446E	DO229035	LICA	ICGC	STVSNFFMNARRRS	DEG_CRL4_CDT2_1	0.1667
p.W444R	DO23416	LINC	ICGC	STVSNFFMNARRRS	DEG_CRL4_CDT2_1	0.2222
p.E447K	DO231016	LUSC	ICGC	STVSNFFMNARRRS	DEG_CRL4_CDT2_1	0.1389
p.S430I	SIDM02050	Colorectal Carcinoma	GDSC	STVSNFFMNARRRS	DEG_CRL4_CDT2_1	0.7341
p.F432L	SIDM01228	Melanoma	GDSC	STVSNFFMNARRRS	DEG_CRL4_CDT2_1	0.6981
p.F432L	ACH-001024	Skin Cancer	CCLE	STVSNFFMNARRRS	DEG_CRL4_CDT2_1	0.6981
p.F432L	CHL-1	skin	COSMIC	STVSNFFMNARRRS	DEG_CRL4_CDT2_1	0.6981

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UBC0	Hepatocyte nuclear factor 6	DEG_CRL4_CDT2_1	427:440	STVSNFFMNARRRS	DTL	0.5893	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons