DegronMD - Q6T4R5(NHS)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R940G	TCGA-05-4382	LUAD	TCGA	IPPFKD	LIG_APCC_ABBA_1	932:937	Mutation rewiring degron network	0.25
p.R940G	DO24900	LUAD	ICGC	IPPFKD	LIG_APCC_ABBA_1	932:937	Mutation rewiring degron network	0.25
p.V780A	TCGA-05-4430	LUAD	TCGA	ADTSS	DEG_SPOP_SBC_1	771:775	Mutation rewiring degron network	0.1944
p.V780A	TCGA-DF-A2KU	UCEC	TCGA	ADTSS	DEG_SPOP_SBC_1	771:775	Mutation rewiring degron network	0.1944
p.V780A	DO23750	LUAD	ICGC	ADTSS	DEG_SPOP_SBC_1	771:775	Mutation rewiring degron network	0.1944
p.V780A	DO223286	UCEC	ICGC	ADTSS	DEG_SPOP_SBC_1	771:775	Mutation rewiring degron network	0.1944
p.G762E	TCGA-19-1791	GBM	TCGA	ADTSS	DEG_SPOP_SBC_1	771:775	Mutation rewiring degron network	0.0833
p.G762E	TCGA-ER-A19K	SKCM	TCGA	ADTSS	DEG_SPOP_SBC_1	771:775	Mutation rewiring degron network	0.0833
p.G762E	DO11489	GBM	ICGC	ADTSS	DEG_SPOP_SBC_1	771:775	Mutation rewiring degron network	0.0833
p.G762E	DO224627	LAML	ICGC	ADTSS	DEG_SPOP_SBC_1	771:775	Mutation rewiring degron network	0.0833
p.G762E	DO47672	SKCM	ICGC	ADTSS	DEG_SPOP_SBC_1	771:775	Mutation rewiring degron network	0.0833
p.G1266C	TCGA-21-5787	LUSC	TCGA	IPENTPTK	DEG_SCF_SKP2-CKS1_1	1258:1265	Mutation rewiring degron network	0.3056
p.G1266C	DO26605	LUSC	ICGC	IPENTPTK	DEG_SCF_SKP2-CKS1_1	1258:1265	Mutation rewiring degron network	0.3056
p.R940I	TCGA-34-2604	LUSC	TCGA	IPPFKD	LIG_APCC_ABBA_1	932:937	Mutation rewiring degron network	0.25
p.R940I	DO26433	LUSC	ICGC	IPPFKD	LIG_APCC_ABBA_1	932:937	Mutation rewiring degron network	0.25
p.D1263N	TCGA-55-7913	LUAD	TCGA	IPENTPTK	DEG_SCF_SKP2-CKS1_1	1258:1265	Mutation altering degron motif	0.6932
p.D1263N	TCGA-EE-A3AF	SKCM	TCGA	IPENTPTK	DEG_SCF_SKP2-CKS1_1	1258:1265	Mutation altering degron motif	0.6932
p.D1263N	DO223665	LUAD	ICGC	IPENTPTK	DEG_SCF_SKP2-CKS1_1	1258:1265	Mutation altering degron motif	0.6932
p.D1263N	DO37911	SKCM	ICGC	IPENTPTK	DEG_SCF_SKP2-CKS1_1	1258:1265	Mutation altering degron motif	0.6932
p.I1608V	TCGA-92-7341	LUSC	TCGA	AASSS	DEG_SPOP_SBC_1	1609:1613	Mutation rewiring degron network	0.3056
p.I1608V	DO26677	LUSC	ICGC	AASSS	DEG_SPOP_SBC_1	1609:1613	Mutation rewiring degron network	0.3056
p.P1620Q	TCGA-A5-A0G1	UCEC	TCGA	AASSS	DEG_SPOP_SBC_1	1609:1613	Mutation rewiring degron network	0.1389
p.P1620Q	DO42472	UCEC	ICGC	AASSS	DEG_SPOP_SBC_1	1609:1613	Mutation rewiring degron network	0.1389
p.R1599Q	TCGA-AA-3672	COAD	TCGA	AASSS	DEG_SPOP_SBC_1	1609:1613	Mutation rewiring degron network	0.0556
p.R1599Q	TCGA-BG-A0M7	UCEC	TCGA	AASSS	DEG_SPOP_SBC_1	1609:1613	Mutation rewiring degron network	0.0556
p.R1599Q	DO9010	COAD	ICGC	AASSS	DEG_SPOP_SBC_1	1609:1613	Mutation rewiring degron network	0.0556
p.R1599Q	DO222875	MELA	ICGC	AASSS	DEG_SPOP_SBC_1	1609:1613	Mutation rewiring degron network	0.0556
p.R1599Q	DO42089	UCEC	ICGC	AASSS	DEG_SPOP_SBC_1	1609:1613	Mutation rewiring degron network	0.0556
p.P1273S	TCGA-AA-3864	COAD	TCGA	IPENTPTK	DEG_SCF_SKP2-CKS1_1	1258:1265	Mutation rewiring degron network	0.1111
p.P1273S	DO8490	COAD	ICGC	IPENTPTK	DEG_SCF_SKP2-CKS1_1	1258:1265	Mutation rewiring degron network	0.1111
p.A1486V	TCGA-AA-3864	COAD	TCGA	PLSSS	DEG_SPOP_SBC_1	1473:1477	Mutation blocking phosphorylation signal	0.5278
p.A1486V	DO8490	COAD	ICGC	PLSSS	DEG_SPOP_SBC_1	1473:1477	Mutation blocking phosphorylation signal	0.5278
p.T1613M	TCGA-AB-2940	LAML	TCGA	AASSS	DEG_SPOP_SBC_1	1609:1613	Mutation altering degron motif	0.7423
p.T1613M	DO21773	LAML	ICGC	AASSS	DEG_SPOP_SBC_1	1609:1613	Mutation altering degron motif	0.7423
p.G775D	TCGA-AJ-A3EK	UCEC	TCGA	ADTSS	DEG_SPOP_SBC_1	771:775	Mutation altering degron motif	0.7198
p.G775D	DO41584	UCEC	ICGC	ADTSS	DEG_SPOP_SBC_1	771:775	Mutation altering degron motif	0.7198
p.R488W	TCGA-AJ-A3IA	UCEC	TCGA	MFTPAVS	DEG_SCF_FBW7_1	493:499	Mutation rewiring degron network	0.1944
p.R488W	DO43082	UCEC	ICGC	MFTPAVS	DEG_SCF_FBW7_1	493:499	Mutation rewiring degron network	0.1944
p.L486I	TCGA-AP-A1DR	UCEC	TCGA	MFTPAVS	DEG_SCF_FBW7_1	493:499	Mutation rewiring degron network	0.1389
p.L486I	DO43747	UCEC	ICGC	MFTPAVS	DEG_SCF_FBW7_1	493:499	Mutation rewiring degron network	0.1389
p.G1252V	TCGA-AP-A1DV	UCEC	TCGA	IPENTPTK	DEG_SCF_SKP2-CKS1_1	1258:1265	Mutation rewiring degron network	0.1667
p.G1252V	DO43186	UCEC	ICGC	IPENTPTK	DEG_SCF_SKP2-CKS1_1	1258:1265	Mutation rewiring degron network	0.1667
p.E509D	TCGA-B5-A3FC	UCEC	TCGA	MFTPAVS	DEG_SCF_FBW7_1	493:499	Mutation rewiring degron network	0.0556
p.E509D	DO41871	UCEC	ICGC	MFTPAVS	DEG_SCF_FBW7_1	493:499	Mutation rewiring degron network	0.0556
p.N944K	TCGA-CA-6717	COAD	TCGA	IPPFKD	LIG_APCC_ABBA_1	932:937	Mutation rewiring degron network	0.1389
p.N944K	DO8264	COAD	ICGC	IPPFKD	LIG_APCC_ABBA_1	932:937	Mutation rewiring degron network	0.1389
p.L933F	TCGA-CN-6011	HNSC	TCGA	IPPFKD	LIG_APCC_ABBA_1	932:937	Mutation altering degron motif	0.6981
p.L933F	DO15791	HNSC	ICGC	IPPFKD	LIG_APCC_ABBA_1	932:937	Mutation altering degron motif	0.6981
p.N1615H	TCGA-D1-A103	UCEC	TCGA	AASSS	DEG_SPOP_SBC_1	1609:1613	Mutation blocking phosphorylation signal	0.7222
p.N1615H	DO42312	UCEC	ICGC	AASSS	DEG_SPOP_SBC_1	1609:1613	Mutation blocking phosphorylation signal	0.7222
p.N1469S	TCGA-D8-A1XK	BRCA	TCGA	DSGDMS	DEG_SCF_TRCP1_1	1460:1465	Mutation substituting flanking lysine	0.3333
p.N1469S	TCGA-D8-A1XK	BRCA	TCGA	PLSSS	DEG_SPOP_SBC_1	1473:1477	Mutation substituting flanking lysine	0.3333
p.N1469S	DO4749	BRCA	ICGC	DSGDMS	DEG_SCF_TRCP1_1	1460:1465	Mutation substituting flanking lysine	0.3333
p.N1469S	DO4749	BRCA	ICGC	PLSSS	DEG_SPOP_SBC_1	1473:1477	Mutation substituting flanking lysine	0.3333
p.G1618W	TCGA-DA-A1IB	SKCM	TCGA	AASSS	DEG_SPOP_SBC_1	1609:1613	Mutation rewiring degron network	0.1944
p.G1618W	DO38033	SKCM	ICGC	AASSS	DEG_SPOP_SBC_1	1609:1613	Mutation rewiring degron network	0.1944
p.Q1270H	TCGA-DF-A2KU	UCEC	TCGA	IPENTPTK	DEG_SCF_SKP2-CKS1_1	1258:1265	Mutation rewiring degron network	0.1944
p.Q1270H	DO223286	UCEC	ICGC	IPENTPTK	DEG_SCF_SKP2-CKS1_1	1258:1265	Mutation rewiring degron network	0.1944
p.D770N	TCGA-DU-6392	LGG	TCGA	ADTSS	DEG_SPOP_SBC_1	771:775	Mutation rewiring degron network	0.3056
p.D770N	DO22237	LGG	ICGC	ADTSS	DEG_SPOP_SBC_1	771:775	Mutation rewiring degron network	0.3056
p.P1249S	TCGA-EE-A29C	SKCM	TCGA	IPENTPTK	DEG_SCF_SKP2-CKS1_1	1258:1265	Mutation rewiring degron network	0.0833
p.P1249S	DO222727	MELA	ICGC	IPENTPTK	DEG_SCF_SKP2-CKS1_1	1258:1265	Mutation rewiring degron network	0.0833
p.P1249S	DO38028	SKCM	ICGC	IPENTPTK	DEG_SCF_SKP2-CKS1_1	1258:1265	Mutation rewiring degron network	0.0833
p.T1471A	TCGA-EJ-7781	PRAD	TCGA	DSGDMS	DEG_SCF_TRCP1_1	1460:1465	Mutation rewiring degron network	0.1667
p.T1471A	TCGA-EJ-7781	PRAD	TCGA	PLSSS	DEG_SPOP_SBC_1	1473:1477	Mutation rewiring degron network	0.2778
p.T1471A	DO36238	PRAD	ICGC	DSGDMS	DEG_SCF_TRCP1_1	1460:1465	Mutation rewiring degron network	0.1667
p.T1471A	DO36238	PRAD	ICGC	PLSSS	DEG_SPOP_SBC_1	1473:1477	Mutation rewiring degron network	0.2778
p.S1609F	TCGA-ER-A194	SKCM	TCGA	AASSS	DEG_SPOP_SBC_1	1609:1613	Mutation altering degron motif	0.7982
p.S1609F	DO47646	SKCM	ICGC	AASSS	DEG_SPOP_SBC_1	1609:1613	Mutation altering degron motif	0.7982
p.D1623Y	TCGA-F5-6571	READ	TCGA	AASSS	DEG_SPOP_SBC_1	1609:1613	Mutation rewiring degron network	0.0556
p.D1623Y	DO36874	READ	ICGC	AASSS	DEG_SPOP_SBC_1	1609:1613	Mutation rewiring degron network	0.0556
p.A1451V	TCGA-FI-A2F4	UCEC	TCGA	DSGDMS	DEG_SCF_TRCP1_1	1460:1465	Mutation rewiring degron network	0.0833
p.A1451V	DO43434	UCEC	ICGC	DSGDMS	DEG_SCF_TRCP1_1	1460:1465	Mutation rewiring degron network	0.0833
p.G494E	TCGA-FW-A3R5	SKCM	TCGA	MFTPAVS	DEG_SCF_FBW7_1	493:499	Mutation altering degron motif	0.7199
p.G494E	DO37406	SKCM	ICGC	MFTPAVS	DEG_SCF_FBW7_1	493:499	Mutation altering degron motif	0.7199
p.G1480S	TCGA-GS-A9TY	DLBC	TCGA	PLSSS	DEG_SPOP_SBC_1	1473:1477	Mutation rewiring degron network	0.25
p.G1480S	DO219917	DLBC	ICGC	PLSSS	DEG_SPOP_SBC_1	1473:1477	Mutation rewiring degron network	0.25
p.G494V	TCGA-L4-A4E5	LUAD	TCGA	MFTPAVS	DEG_SCF_FBW7_1	493:499	Mutation altering degron motif	0.7532
p.G494V	DO24320	LUAD	ICGC	MFTPAVS	DEG_SCF_FBW7_1	493:499	Mutation altering degron motif	0.7532
p.T1603M	TCGA-R5-A805	STAD	TCGA	AASSS	DEG_SPOP_SBC_1	1609:1613	Mutation rewiring degron network	0.1667
p.T1603M	DO48448	BLCA	ICGC	AASSS	DEG_SPOP_SBC_1	1609:1613	Mutation rewiring degron network	0.1667
p.T1603M	DO222346	STAD	ICGC	AASSS	DEG_SPOP_SBC_1	1609:1613	Mutation rewiring degron network	0.1667
p.L927F	TCGA-VS-A8QC	CESC	TCGA	IPPFKD	LIG_APCC_ABBA_1	932:937	Mutation rewiring degron network	0.1944
p.L927F	DO51628	CESC	ICGC	IPPFKD	LIG_APCC_ABBA_1	932:937	Mutation rewiring degron network	0.1944
p.S1475I	TCGA-WY-A859	LGG	TCGA	PLSSS	DEG_SPOP_SBC_1	1473:1477	Mutation altering degron motif	0.7341
p.S1475I	DO219859	LGG	ICGC	PLSSS	DEG_SPOP_SBC_1	1473:1477	Mutation altering degron motif	0.7341
p.K777N	DO7334	CLLE	ICGC	ADTSS	DEG_SPOP_SBC_1	771:775	Mutation rewiring degron network	0.2778
p.Y764C	DO233200	GACA	ICGC	ADTSS	DEG_SPOP_SBC_1	771:775	Mutation rewiring degron network	0.1389
p.A1486S	DO229022	LICA	ICGC	PLSSS	DEG_SPOP_SBC_1	1473:1477	Mutation blocking phosphorylation signal	0.5278
p.A1258S	DO229032	LICA	ICGC	IPENTPTK	DEG_SCF_SKP2-CKS1_1	1258:1265	Mutation altering degron motif	0.7588
p.A1258S	DO229009	LICA	ICGC	IPENTPTK	DEG_SCF_SKP2-CKS1_1	1258:1265	Mutation altering degron motif	0.7588
p.G490C	DO50933	LICA	ICGC	MFTPAVS	DEG_SCF_FBW7_1	493:499	Mutation rewiring degron network	0.25
p.P504H	DO50727	ORCA	ICGC	MFTPAVS	DEG_SCF_FBW7_1	493:499	Mutation blocking phosphorylation signal	0.6389
p.I1482M	DO46342	OV	ICGC	PLSSS	DEG_SPOP_SBC_1	1473:1477	Mutation rewiring degron network	0.1944
p.R484W	DO33084	PACA	ICGC	MFTPAVS	DEG_SCF_FBW7_1	493:499	Mutation rewiring degron network	0.0833
p.A502D	DO229257	THCA	ICGC	MFTPAVS	DEG_SCF_FBW7_1	493:499	Mutation rewiring degron network	0.25
p.H923L	SIDM01169	Ovarian Carcinoma	GDSC	IPPFKD	LIG_APCC_ABBA_1	932:937	Mutation substituting flanking lysine	0.1944
p.H923L	SIDM00555	Glioblastoma	GDSC	IPPFKD	LIG_APCC_ABBA_1	932:937	Mutation substituting flanking lysine	0.1944
p.H923L	SIDM00241	Breast Carcinoma	GDSC	IPPFKD	LIG_APCC_ABBA_1	932:937	Mutation substituting flanking lysine	0.1944
p.H923L	SIDM00279	Gastric Carcinoma	GDSC	IPPFKD	LIG_APCC_ABBA_1	932:937	Mutation substituting flanking lysine	0.1944
p.S778T	SIDM00845	Burkitt's Lymphoma	GDSC	ADTSS	DEG_SPOP_SBC_1	771:775	Mutation rewiring degron network	0.25
p.G1272V	SIDM01103	Squamous Cell Lung Carcinoma	GDSC	IPENTPTK	DEG_SCF_SKP2-CKS1_1	1258:1265	Mutation rewiring degron network	0.1389
p.G1272V	ACH-000665	Lung Cancer	CCLE	IPENTPTK	DEG_SCF_SKP2-CKS1_1	1258:1265	Mutation rewiring degron network	0.1389
p.G1272V	SK-MES-1	lung	COSMIC	IPENTPTK	DEG_SCF_SKP2-CKS1_1	1258:1265	Mutation rewiring degron network	0.1389
p.S1461T	SIDM00323	B-Cell Non-Hodgkin's Lymphoma	GDSC	DSGDMS	DEG_SCF_TRCP1_1	1460:1465	Mutation altering degron motif	0.8227
p.S1461T	ACH-002313	Lymphoma	CCLE	DSGDMS	DEG_SCF_TRCP1_1	1460:1465	Mutation altering degron motif	0.8227
p.S1461T	TK	haematopoietic and lymphoid tissue	COSMIC	DSGDMS	DEG_SCF_TRCP1_1	1460:1465	Mutation altering degron motif	0.8227
p.R1484Q	SIDM00533	Pancreatic Carcinoma	GDSC	PLSSS	DEG_SPOP_SBC_1	1473:1477	Mutation rewiring degron network	0.1389
p.R1484Q	ACH-000118	Pancreatic Cancer	CCLE	PLSSS	DEG_SPOP_SBC_1	1473:1477	Mutation rewiring degron network	0.1389
p.R1484Q	HuP-T3	pancreas	COSMIC	PLSSS	DEG_SPOP_SBC_1	1473:1477	Mutation rewiring degron network	0.1389
p.R484Q	SIDM00801	Melanoma	GDSC	MFTPAVS	DEG_SCF_FBW7_1	493:499	Mutation rewiring degron network	0.0833
p.R484Q	ACH-000008	Skin Cancer	CCLE	MFTPAVS	DEG_SCF_FBW7_1	493:499	Mutation rewiring degron network	0.0833
p.R484Q	ACH-000014	Metastasis	CCLE	MFTPAVS	DEG_SCF_FBW7_1	493:499	Mutation rewiring degron network	0.0833
p.R484Q	A101D	skin	COSMIC	MFTPAVS	DEG_SCF_FBW7_1	493:499	Mutation rewiring degron network	0.0833
p.S1462Y	SIDM00149	Melanoma	GDSC	DSGDMS	DEG_SCF_TRCP1_1	1460:1465	Mutation altering degron motif	0.712
p.S1462Y	SIDM00758	Non-Small Cell Lung Carcinoma	GDSC	DSGDMS	DEG_SCF_TRCP1_1	1460:1465	Mutation altering degron motif	0.712
p.S1462Y	ACH-000750	Skin Cancer	CCLE	DSGDMS	DEG_SCF_TRCP1_1	1460:1465	Mutation altering degron motif	0.712
p.S1462Y	ACH-001137	Lung Cancer	CCLE	DSGDMS	DEG_SCF_TRCP1_1	1460:1465	Mutation altering degron motif	0.712
p.S1462Y	NCI-H1993	lung	COSMIC	DSGDMS	DEG_SCF_TRCP1_1	1460:1465	Mutation altering degron motif	0.712
p.S1462Y	LOXIMVI	skin	COSMIC	DSGDMS	DEG_SCF_TRCP1_1	1460:1465	Mutation altering degron motif	0.712
p.K777R	SIDM00711	Squamous Cell Lung Carcinoma	GDSC	ADTSS	DEG_SPOP_SBC_1	771:775	Mutation rewiring degron network	0.2778
p.K777R	ACH-000727	Lung Cancer	CCLE	ADTSS	DEG_SPOP_SBC_1	771:775	Mutation rewiring degron network	0.2778
p.K777R	NCI-H2066	lung	COSMIC	ADTSS	DEG_SPOP_SBC_1	771:775	Mutation rewiring degron network	0.2778
p.R1260C	SIDM00783	Colorectal Carcinoma	GDSC	IPENTPTK	DEG_SCF_SKP2-CKS1_1	1258:1265	Mutation altering degron motif	0.8301
p.R1260C	ACH-000971	Colon/Colorectal Cancer	CCLE	IPENTPTK	DEG_SCF_SKP2-CKS1_1	1258:1265	Mutation altering degron motif	0.8301
p.R1260C	HCT-116	large intestine	COSMIC	IPENTPTK	DEG_SCF_SKP2-CKS1_1	1258:1265	Mutation altering degron motif	0.8301
p.S1458G	SIDM00451	T-Lymphoblastic Leukemia	GDSC	DSGDMS	DEG_SCF_TRCP1_1	1460:1465	Mutation rewiring degron network	0.2778
p.S1458G	ACH-000937	Leukemia	CCLE	DSGDMS	DEG_SCF_TRCP1_1	1460:1465	Mutation rewiring degron network	0.2778
p.S1458G	PF-382	haematopoietic and lymphoid tissue	COSMIC	DSGDMS	DEG_SCF_TRCP1_1	1460:1465	Mutation rewiring degron network	0.2778
p.A1607S	SIDM00755	Non-Small Cell Lung Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	1609:1613	Mutation rewiring degron network	0.2778
p.A1607S	ACH-000888	Lung Cancer	CCLE	AASSS	DEG_SPOP_SBC_1	1609:1613	Mutation rewiring degron network	0.2778
p.A1607S	NCI-H1793	lung	COSMIC	AASSS	DEG_SPOP_SBC_1	1609:1613	Mutation rewiring degron network	0.2778
p.S1478C	SIDM00976	Melanoma	GDSC	PLSSS	DEG_SPOP_SBC_1	1473:1477	Mutation rewiring degron network	0.3056
p.S1478C	ACH-002205	Skin Cancer	CCLE	PLSSS	DEG_SPOP_SBC_1	1473:1477	Mutation rewiring degron network	0.3056
p.S1478C	WM1552C	skin	COSMIC	PLSSS	DEG_SPOP_SBC_1	1473:1477	Mutation rewiring degron network	0.3056
p.N931D	SIDM00859	B-Cell Non-Hodgkin's Lymphoma	GDSC	IPPFKD	LIG_APCC_ABBA_1	932:937	Mutation rewiring degron network	0.3056
p.N931D	ACH-001498	Lymphoma	CCLE	IPPFKD	LIG_APCC_ABBA_1	932:937	Mutation rewiring degron network	0.3056
p.N931D	Farage	haematopoietic and lymphoid tissue	COSMIC	IPPFKD	LIG_APCC_ABBA_1	932:937	Mutation rewiring degron network	0.3056
p.N936D	SIDM01696	Mesothelioma	GDSC	IPPFKD	LIG_APCC_ABBA_1	932:937	Mutation altering degron motif	0.6932
p.N936D	ACH-000645	Lung Cancer	CCLE	IPPFKD	LIG_APCC_ABBA_1	932:937	Mutation altering degron motif	0.6932
p.D1617N	SIDM01729	Endometrial Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	1609:1613	Mutation rewiring degron network	0.2222
p.D1617N	ACH-000909	Endometrial/Uterine Cancer	CCLE	AASSS	DEG_SPOP_SBC_1	1609:1613	Mutation rewiring degron network	0.2222
p.Q1270R	ACH-000829	Myeloma	CCLE	IPENTPTK	DEG_SCF_SKP2-CKS1_1	1258:1265	Mutation rewiring degron network	0.1944
p.G1618R	ACH-000901	Lung Cancer	CCLE	AASSS	DEG_SPOP_SBC_1	1609:1613	Mutation rewiring degron network	0.1944
p.A1460T	ACH-001991	Primary	CCLE	DSGDMS	DEG_SCF_TRCP1_1	1460:1465	Mutation altering degron motif	0.7139
p.V503M	RL95-2	endometrium	COSMIC	MFTPAVS	DEG_SCF_FBW7_1	493:499	Mutation rewiring degron network	0.2222
p.A765T	HEC-1	endometrium	COSMIC	ADTSS	DEG_SPOP_SBC_1	771:775	Mutation substituting flanking lysine	0.2778
p.N775D	Farage	haematopoietic and lymphoid tissue	COSMIC	ADTSS	DEG_SPOP_SBC_1	771:775	Mutation altering degron motif	0.6932
p.A503S	SNU-387	liver	COSMIC	MFTPAVS	DEG_SCF_FBW7_1	493:499	Mutation rewiring degron network	0.2222
p.S1275G	PF-382	haematopoietic and lymphoid tissue	COSMIC	IPENTPTK	DEG_SCF_SKP2-CKS1_1	1258:1265	Mutation rewiring degron network	0.0556
p.N772D	Farage	haematopoietic and lymphoid tissue	COSMIC	ADTSS	DEG_SPOP_SBC_1	771:775	Mutation altering degron motif	0.6932
p.R1262Q	DND-41	haematopoietic and lymphoid tissue	COSMIC	IPENTPTK	DEG_SCF_SKP2-CKS1_1	1258:1265	Mutation altering degron motif	0.7329
p.A1451S	NCI-H1793	lung	COSMIC	DSGDMS	DEG_SCF_TRCP1_1	1460:1465	Mutation rewiring degron network	0.0833
p.V506M	RL95-2	endometrium	COSMIC	MFTPAVS	DEG_SCF_FBW7_1	493:499	Mutation blocking phosphorylation signal	0.5833
p.R1259Q	DND-41	haematopoietic and lymphoid tissue	COSMIC	IPENTPTK	DEG_SCF_SKP2-CKS1_1	1258:1265	Mutation altering degron motif	0.7329
p.S1257F	HCC2998	large intestine	COSMIC	IPENTPTK	DEG_SCF_SKP2-CKS1_1	1258:1265	Mutation rewiring degron network	0.3056
p.S1257F	SW684	soft tissue	COSMIC	IPENTPTK	DEG_SCF_SKP2-CKS1_1	1258:1265	Mutation rewiring degron network	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NHS

UniProt ID: Q6T4R5

Entrez ID: 4810

Protein name: Nance-Horan syndrome protein (Congenital cataracts and dental anomalies protein)

External links: UniprotKB HGNC RefSeq COSMIC

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