DegronMD

Uniprot ID: Q6T4R5

Source protein: Nance-Horan syndrome protein

Source gene: NHS

Class: DEG_SCF_FBW7_1

Location: 493:499

E3 ligase: FBXW7

DEGRON score: 0.9974

ASA_SCORE: 76.8714

COIL: 0.713

CONS_SCORE: 0.2907

DSS_SCORE: 0.5809

HELIX: 0.0664

FCONS_SCORE: 0.5672

RIG_SCORE: 0.7249

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R488W	TCGA-AJ-A3IA	UCEC	TCGA	MFTPAVS	DEG_SCF_FBW7_1	0.1944
p.R488W	DO43082	UCEC	ICGC	MFTPAVS	DEG_SCF_FBW7_1	0.1944
p.L486I	TCGA-AP-A1DR	UCEC	TCGA	MFTPAVS	DEG_SCF_FBW7_1	0.1389
p.L486I	DO43747	UCEC	ICGC	MFTPAVS	DEG_SCF_FBW7_1	0.1389
p.E509D	TCGA-B5-A3FC	UCEC	TCGA	MFTPAVS	DEG_SCF_FBW7_1	0.0556
p.E509D	DO41871	UCEC	ICGC	MFTPAVS	DEG_SCF_FBW7_1	0.0556
p.G494E	TCGA-FW-A3R5	SKCM	TCGA	MFTPAVS	DEG_SCF_FBW7_1	0.7199
p.G494E	DO37406	SKCM	ICGC	MFTPAVS	DEG_SCF_FBW7_1	0.7199
p.G494V	TCGA-L4-A4E5	LUAD	TCGA	MFTPAVS	DEG_SCF_FBW7_1	0.7532
p.G494V	DO24320	LUAD	ICGC	MFTPAVS	DEG_SCF_FBW7_1	0.7532
p.G490C	DO50933	LICA	ICGC	MFTPAVS	DEG_SCF_FBW7_1	0.25
p.P504H	DO50727	ORCA	ICGC	MFTPAVS	DEG_SCF_FBW7_1	0.6389
p.R484W	DO33084	PACA	ICGC	MFTPAVS	DEG_SCF_FBW7_1	0.0833
p.A502D	DO229257	THCA	ICGC	MFTPAVS	DEG_SCF_FBW7_1	0.25
p.R484Q	SIDM00801	Melanoma	GDSC	MFTPAVS	DEG_SCF_FBW7_1	0.0833
p.R484Q	ACH-000008	Skin Cancer	CCLE	MFTPAVS	DEG_SCF_FBW7_1	0.0833
p.R484Q	ACH-000014	Metastasis	CCLE	MFTPAVS	DEG_SCF_FBW7_1	0.0833
p.R484Q	A101D	skin	COSMIC	MFTPAVS	DEG_SCF_FBW7_1	0.0833
p.V503M	RL95-2	endometrium	COSMIC	MFTPAVS	DEG_SCF_FBW7_1	0.2222
p.A503S	SNU-387	liver	COSMIC	MFTPAVS	DEG_SCF_FBW7_1	0.2222
p.V506M	RL95-2	endometrium	COSMIC	MFTPAVS	DEG_SCF_FBW7_1	0.5833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6T4R5	Nance-Horan syndrome protein	DEG_SCF_FBW7_1	493:499	MFTPAVS	FBXW7	0.9974	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons