DegronMD

Uniprot ID: Q6T4R5

Source protein: Nance-Horan syndrome protein

Source gene: NHS

Class: DEG_SCF_SKP2-CKS1_1

Location: 1258:1265

E3 ligase: SKP2,CSK1

DEGRON score: 0.9982

ASA_SCORE: 102.2875

COIL: 0.944

CONS_SCORE: 0.265

DSS_SCORE: 0.6496

HELIX: 0.0315

FCONS_SCORE: 1.033

RIG_SCORE: 0.6946

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G1266C	TCGA-21-5787	LUSC	TCGA	IPENTPTK	DEG_SCF_SKP2-CKS1_1	0.3056
p.G1266C	DO26605	LUSC	ICGC	IPENTPTK	DEG_SCF_SKP2-CKS1_1	0.3056
p.D1263N	TCGA-55-7913	LUAD	TCGA	IPENTPTK	DEG_SCF_SKP2-CKS1_1	0.6932
p.D1263N	TCGA-EE-A3AF	SKCM	TCGA	IPENTPTK	DEG_SCF_SKP2-CKS1_1	0.6932
p.D1263N	DO223665	LUAD	ICGC	IPENTPTK	DEG_SCF_SKP2-CKS1_1	0.6932
p.D1263N	DO37911	SKCM	ICGC	IPENTPTK	DEG_SCF_SKP2-CKS1_1	0.6932
p.P1273S	TCGA-AA-3864	COAD	TCGA	IPENTPTK	DEG_SCF_SKP2-CKS1_1	0.1111
p.P1273S	DO8490	COAD	ICGC	IPENTPTK	DEG_SCF_SKP2-CKS1_1	0.1111
p.G1252V	TCGA-AP-A1DV	UCEC	TCGA	IPENTPTK	DEG_SCF_SKP2-CKS1_1	0.1667
p.G1252V	DO43186	UCEC	ICGC	IPENTPTK	DEG_SCF_SKP2-CKS1_1	0.1667
p.Q1270H	TCGA-DF-A2KU	UCEC	TCGA	IPENTPTK	DEG_SCF_SKP2-CKS1_1	0.1944
p.Q1270H	DO223286	UCEC	ICGC	IPENTPTK	DEG_SCF_SKP2-CKS1_1	0.1944
p.P1249S	TCGA-EE-A29C	SKCM	TCGA	IPENTPTK	DEG_SCF_SKP2-CKS1_1	0.0833
p.P1249S	DO222727	MELA	ICGC	IPENTPTK	DEG_SCF_SKP2-CKS1_1	0.0833
p.P1249S	DO38028	SKCM	ICGC	IPENTPTK	DEG_SCF_SKP2-CKS1_1	0.0833
p.A1258S	DO229032	LICA	ICGC	IPENTPTK	DEG_SCF_SKP2-CKS1_1	0.7588
p.A1258S	DO229009	LICA	ICGC	IPENTPTK	DEG_SCF_SKP2-CKS1_1	0.7588
p.G1272V	SIDM01103	Squamous Cell Lung Carcinoma	GDSC	IPENTPTK	DEG_SCF_SKP2-CKS1_1	0.1389
p.G1272V	ACH-000665	Lung Cancer	CCLE	IPENTPTK	DEG_SCF_SKP2-CKS1_1	0.1389
p.G1272V	SK-MES-1	lung	COSMIC	IPENTPTK	DEG_SCF_SKP2-CKS1_1	0.1389
p.R1260C	SIDM00783	Colorectal Carcinoma	GDSC	IPENTPTK	DEG_SCF_SKP2-CKS1_1	0.8301
p.R1260C	ACH-000971	Colon/Colorectal Cancer	CCLE	IPENTPTK	DEG_SCF_SKP2-CKS1_1	0.8301
p.R1260C	HCT-116	large_intestine	COSMIC	IPENTPTK	DEG_SCF_SKP2-CKS1_1	0.8301
p.Q1270R	ACH-000829	Myeloma	CCLE	IPENTPTK	DEG_SCF_SKP2-CKS1_1	0.1944
p.S1275G	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	IPENTPTK	DEG_SCF_SKP2-CKS1_1	0.0556
p.R1262Q	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	IPENTPTK	DEG_SCF_SKP2-CKS1_1	0.7329
p.R1259Q	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	IPENTPTK	DEG_SCF_SKP2-CKS1_1	0.7329
p.S1257F	HCC2998	large_intestine	COSMIC	IPENTPTK	DEG_SCF_SKP2-CKS1_1	0.3056
p.S1257F	SW684	soft_tissue	COSMIC	IPENTPTK	DEG_SCF_SKP2-CKS1_1	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: IPENTPTK

Degron related mutations and impact score

Drug responses associated with NHS mutations

All proteins holding degron of IPENTPTK

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6T4R5	Nance-Horan syndrome protein	DEG_SCF_SKP2-CKS1_1	1258:1265	IPENTPTK	SKP2,CSK1	0.9982	More...