DegronMD

Uniprot ID: Q6T4R5

Source protein: Nance-Horan syndrome protein

Source gene: NHS

Class: DEG_SCF_TRCP1_1

Location: 1460:1465

E3 ligase: BTRC

DEGRON score: 0.7995

ASA_SCORE: 75.5833

COIL: 0.7612

CONS_SCORE: 0.311

DSS_SCORE: 0.598

HELIX: 0.1835

FCONS_SCORE: 0.8918

RIG_SCORE: 0.66

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N1469S	TCGA-D8-A1XK	BRCA	TCGA	DSGDMS	DEG_SCF_TRCP1_1	0.3333
p.N1469S	DO4749	BRCA	ICGC	DSGDMS	DEG_SCF_TRCP1_1	0.3333
p.T1471A	TCGA-EJ-7781	PRAD	TCGA	DSGDMS	DEG_SCF_TRCP1_1	0.1667
p.T1471A	DO36238	PRAD	ICGC	DSGDMS	DEG_SCF_TRCP1_1	0.1667
p.A1451V	TCGA-FI-A2F4	UCEC	TCGA	DSGDMS	DEG_SCF_TRCP1_1	0.0833
p.A1451V	DO43434	UCEC	ICGC	DSGDMS	DEG_SCF_TRCP1_1	0.0833
p.S1461T	SIDM00323	B-Cell Non-Hodgkin's Lymphoma	GDSC	DSGDMS	DEG_SCF_TRCP1_1	0.8227
p.S1461T	ACH-002313	Lymphoma	CCLE	DSGDMS	DEG_SCF_TRCP1_1	0.8227
p.S1461T	TK	haematopoietic_and_lymphoid_tissue	COSMIC	DSGDMS	DEG_SCF_TRCP1_1	0.8227
p.S1462Y	SIDM00149	Melanoma	GDSC	DSGDMS	DEG_SCF_TRCP1_1	0.712
p.S1462Y	SIDM00758	Non-Small Cell Lung Carcinoma	GDSC	DSGDMS	DEG_SCF_TRCP1_1	0.712
p.S1462Y	ACH-000750	Skin Cancer	CCLE	DSGDMS	DEG_SCF_TRCP1_1	0.712
p.S1462Y	ACH-001137	Lung Cancer	CCLE	DSGDMS	DEG_SCF_TRCP1_1	0.712
p.S1462Y	NCI-H1993	lung	COSMIC	DSGDMS	DEG_SCF_TRCP1_1	0.712
p.S1462Y	LOXIMVI	skin	COSMIC	DSGDMS	DEG_SCF_TRCP1_1	0.712
p.S1458G	SIDM00451	T-Lymphoblastic Leukemia	GDSC	DSGDMS	DEG_SCF_TRCP1_1	0.2778
p.S1458G	ACH-000937	Leukemia	CCLE	DSGDMS	DEG_SCF_TRCP1_1	0.2778
p.S1458G	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	DSGDMS	DEG_SCF_TRCP1_1	0.2778
p.A1460T	ACH-001991	Primary	CCLE	DSGDMS	DEG_SCF_TRCP1_1	0.7139
p.A1451S	NCI-H1793	lung	COSMIC	DSGDMS	DEG_SCF_TRCP1_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6T4R5	Nance-Horan syndrome protein	DEG_SCF_TRCP1_1	1460:1465	DSGDMS	BTRC	0.7995	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons