DegronMD

Uniprot ID: Q6T4R5

Source protein: Nance-Horan syndrome protein

Source gene: NHS

Class: LIG_APCC_ABBA_1

Location: 932:937

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9925

ASA_SCORE: 80.0333

COIL: 0.899

CONS_SCORE: 0.4956

DSS_SCORE: 0.553

HELIX: 0.058

FCONS_SCORE: 1.0751

RIG_SCORE: 0.7258

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R940G	TCGA-05-4382	LUAD	TCGA	IPPFKD	LIG_APCC_ABBA_1	0.25
p.R940G	DO24900	LUAD	ICGC	IPPFKD	LIG_APCC_ABBA_1	0.25
p.R940I	TCGA-34-2604	LUSC	TCGA	IPPFKD	LIG_APCC_ABBA_1	0.25
p.R940I	DO26433	LUSC	ICGC	IPPFKD	LIG_APCC_ABBA_1	0.25
p.N944K	TCGA-CA-6717	COAD	TCGA	IPPFKD	LIG_APCC_ABBA_1	0.1389
p.N944K	DO8264	COAD	ICGC	IPPFKD	LIG_APCC_ABBA_1	0.1389
p.L933F	TCGA-CN-6011	HNSC	TCGA	IPPFKD	LIG_APCC_ABBA_1	0.6981
p.L933F	DO15791	HNSC	ICGC	IPPFKD	LIG_APCC_ABBA_1	0.6981
p.L927F	TCGA-VS-A8QC	CESC	TCGA	IPPFKD	LIG_APCC_ABBA_1	0.1944
p.L927F	DO51628	CESC	ICGC	IPPFKD	LIG_APCC_ABBA_1	0.1944
p.H923L	SIDM01169	Ovarian Carcinoma	GDSC	IPPFKD	LIG_APCC_ABBA_1	0.1944
p.H923L	SIDM00555	Glioblastoma	GDSC	IPPFKD	LIG_APCC_ABBA_1	0.1944
p.H923L	SIDM00241	Breast Carcinoma	GDSC	IPPFKD	LIG_APCC_ABBA_1	0.1944
p.H923L	SIDM00279	Gastric Carcinoma	GDSC	IPPFKD	LIG_APCC_ABBA_1	0.1944
p.N931D	SIDM00859	B-Cell Non-Hodgkin's Lymphoma	GDSC	IPPFKD	LIG_APCC_ABBA_1	0.3056
p.N931D	ACH-001498	Lymphoma	CCLE	IPPFKD	LIG_APCC_ABBA_1	0.3056
p.N931D	Farage	haematopoietic_and_lymphoid_tissue	COSMIC	IPPFKD	LIG_APCC_ABBA_1	0.3056
p.N936D	SIDM01696	Mesothelioma	GDSC	IPPFKD	LIG_APCC_ABBA_1	0.6932
p.N936D	ACH-000645	Lung Cancer	CCLE	IPPFKD	LIG_APCC_ABBA_1	0.6932

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6T4R5	Nance-Horan syndrome protein	LIG_APCC_ABBA_1	932:937	IPPFKD	APC,CDC20,FZR1	0.9925	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons