DegronMD - Q8IZ21(PHACTR4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.M441I	TCGA-55-6987	LUAD	TCGA	LPMTPILE	DEG_SCF_FBW7_2	429:436	Mutation rewiring degron network	0.1944
p.M441I	DO25379	LUAD	ICGC	LPMTPILE	DEG_SCF_FBW7_2	429:436	Mutation rewiring degron network	0.1944
p.N172D	TCGA-A5-A1OF	UCEC	TCGA	PLSSS	DEG_SPOP_SBC_1	174:178	Mutation rewiring degron network	0.2778
p.N172D	DO42568	UCEC	ICGC	PLSSS	DEG_SPOP_SBC_1	174:178	Mutation rewiring degron network	0.2778
p.R430Q	TCGA-AX-A05Z	UCEC	TCGA	LPMTPILE	DEG_SCF_FBW7_2	429:436	Mutation altering degron motif	0.7329
p.R430Q	DO40884	UCEC	ICGC	LPMTPILE	DEG_SCF_FBW7_2	429:436	Mutation altering degron motif	0.7329
p.P177H	TCGA-D1-A103	UCEC	TCGA	PLSSS	DEG_SPOP_SBC_1	174:178	Mutation altering degron motif	0.7694
p.P177H	DO42312	UCEC	ICGC	PLSSS	DEG_SPOP_SBC_1	174:178	Mutation altering degron motif	0.7694
p.T368I	TCGA-DA-A1HV	SKCM	TCGA	LDLHQE	LIG_APCC_ABBA_1	378:383	Mutation rewiring degron network	0.0556
p.T368I	DO37659	SKCM	ICGC	LDLHQE	LIG_APCC_ABBA_1	378:383	Mutation rewiring degron network	0.0556
p.L390I	DO228947	LICA	ICGC	LDLHQE	LIG_APCC_ABBA_1	378:383	Mutation rewiring degron network	0.1389
p.E167D	DO229031	LICA	ICGC	PLSSS	DEG_SPOP_SBC_1	174:178	Mutation rewiring degron network	0.1389
p.P424S	DO45275	LIRI	ICGC	LPMTPILE	DEG_SCF_FBW7_2	429:436	Mutation rewiring degron network	0.1944
p.P443L	DO222710	MELA	ICGC	LPMTPILE	DEG_SCF_FBW7_2	429:436	Mutation blocking phosphorylation signal	0.5833
p.P372S	DO218856	SKCA	ICGC	LDLHQE	LIG_APCC_ABBA_1	378:383	Mutation rewiring degron network	0.1667
p.E381Q	SIDM00995	Other Solid Cancers	GDSC	LDLHQE	LIG_APCC_ABBA_1	378:383	Mutation altering degron motif	0.6744
p.E381Q	ACH-001328	Skin Cancer	CCLE	LDLHQE	LIG_APCC_ABBA_1	378:383	Mutation altering degron motif	0.6744
p.E381Q	A431	skin	COSMIC	LDLHQE	LIG_APCC_ABBA_1	378:383	Mutation altering degron motif	0.6744
p.P440S	SIDM00203	Ewing's Sarcoma	GDSC	LPMTPILE	DEG_SCF_FBW7_2	429:436	Mutation rewiring degron network	0.2222
p.P440S	SIDM00256	Neuroblastoma	GDSC	LPMTPILE	DEG_SCF_FBW7_2	429:436	Mutation rewiring degron network	0.2222
p.P440S	SIDM00479	Esophageal Carcinoma	GDSC	LPMTPILE	DEG_SCF_FBW7_2	429:436	Mutation rewiring degron network	0.2222
p.A434T	SIDM00574	Glioblastoma	GDSC	LPMTPILE	DEG_SCF_FBW7_2	429:436	Mutation altering degron motif	0.7139
p.A434T	no-10	central nervous system	COSMIC	LPMTPILE	DEG_SCF_FBW7_2	429:436	Mutation altering degron motif	0.7139
p.T442I	SIDM00982	Glioblastoma	GDSC	LPMTPILE	DEG_SCF_FBW7_2	429:436	Mutation rewiring degron network	0.1667
p.T442I	ACH-000323	Brain Cancer	CCLE	LPMTPILE	DEG_SCF_FBW7_2	429:436	Mutation rewiring degron network	0.1667
p.T442I	42-MG-BA	central nervous system	COSMIC	LPMTPILE	DEG_SCF_FBW7_2	429:436	Mutation rewiring degron network	0.1667
p.E171D	ACH-001389	Breast Cancer	CCLE	PLSSS	DEG_SPOP_SBC_1	174:178	Mutation rewiring degron network	0.25
p.P184L	ACH-001450	Lymphoma	CCLE	PLSSS	DEG_SPOP_SBC_1	174:178	Mutation rewiring degron network	0.1667
p.M441K	ACH-001523	Skin Cancer	CCLE	LPMTPILE	DEG_SCF_FBW7_2	429:436	Mutation rewiring degron network	0.1944
p.A424T	ACH-001605	Brain Cancer	CCLE	LPMTPILE	DEG_SCF_FBW7_2	429:436	Mutation rewiring degron network	0.1944
p.A424T	no-10	central nervous system	COSMIC	LPMTPILE	DEG_SCF_FBW7_2	429:436	Mutation rewiring degron network	0.1944
p.E371Q	A431	skin	COSMIC	LDLHQE	LIG_APCC_ABBA_1	378:383	Mutation rewiring degron network	0.1389
p.P385L	RT4	urinary tract	COSMIC	LDLHQE	LIG_APCC_ABBA_1	378:383	Mutation rewiring degron network	0.2778
p.T432I	42-MG-BA	central nervous system	COSMIC	LPMTPILE	DEG_SCF_FBW7_2	429:436	Mutation altering degron motif	0.8189

Kaplan plot for PHACTR4 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PHACTR4

UniProt ID: Q8IZ21

Entrez ID: 65979

Protein name: Phosphatase and actin regulator 4

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PHACTR4 in