DegronMD

Uniprot ID: Q8IZ21

Source protein: Phosphatase and actin regulator 4

Source gene: PHACTR4

Class: LIG_APCC_ABBA_1

Location: 378:383

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9386

ASA_SCORE: 95.7667

COIL: 0.7518

CONS_SCORE: 0.3764

DSS_SCORE: 0.7057

HELIX: 0.2162

FCONS_SCORE: 1.1569

RIG_SCORE: 0.7304

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T368I	TCGA-DA-A1HV	SKCM	TCGA	LDLHQE	LIG_APCC_ABBA_1	0.0556
p.T368I	DO37659	SKCM	ICGC	LDLHQE	LIG_APCC_ABBA_1	0.0556
p.L390I	DO228947	LICA	ICGC	LDLHQE	LIG_APCC_ABBA_1	0.1389
p.P372S	DO218856	SKCA	ICGC	LDLHQE	LIG_APCC_ABBA_1	0.1667
p.E381Q	SIDM00995	Other Solid Cancers	GDSC	LDLHQE	LIG_APCC_ABBA_1	0.6744
p.E381Q	ACH-001328	Skin Cancer	CCLE	LDLHQE	LIG_APCC_ABBA_1	0.6744
p.E381Q	A431	skin	COSMIC	LDLHQE	LIG_APCC_ABBA_1	0.6744
p.E371Q	A431	skin	COSMIC	LDLHQE	LIG_APCC_ABBA_1	0.1389
p.P385L	RT4	urinary_tract	COSMIC	LDLHQE	LIG_APCC_ABBA_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IZ21	Phosphatase and actin regulator 4	LIG_APCC_ABBA_1	378:383	LDLHQE	APC,CDC20,FZR1	0.9386	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons