DegronMD

Uniprot ID: Q8IZ21

Source protein: Phosphatase and actin regulator 4

Source gene: PHACTR4

Class: DEG_SCF_FBW7_2

Location: 429:436

E3 ligase: FBXW7

DEGRON score: 0.9924

ASA_SCORE: 89.15

COIL: 0.9365

CONS_SCORE: 0.4086

DSS_SCORE: 0.4497

HELIX: 0.0326

FCONS_SCORE: 1.1163

RIG_SCORE: 0.7049

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M441I	TCGA-55-6987	LUAD	TCGA	LPMTPILE	DEG_SCF_FBW7_2	0.1944
p.M441I	DO25379	LUAD	ICGC	LPMTPILE	DEG_SCF_FBW7_2	0.1944
p.R430Q	TCGA-AX-A05Z	UCEC	TCGA	LPMTPILE	DEG_SCF_FBW7_2	0.7329
p.R430Q	DO40884	UCEC	ICGC	LPMTPILE	DEG_SCF_FBW7_2	0.7329
p.P424S	DO45275	LIRI	ICGC	LPMTPILE	DEG_SCF_FBW7_2	0.1944
p.P443L	DO222710	MELA	ICGC	LPMTPILE	DEG_SCF_FBW7_2	0.5833
p.P440S	SIDM00203	Ewing's Sarcoma	GDSC	LPMTPILE	DEG_SCF_FBW7_2	0.2222
p.P440S	SIDM00256	Neuroblastoma	GDSC	LPMTPILE	DEG_SCF_FBW7_2	0.2222
p.P440S	SIDM00479	Esophageal Carcinoma	GDSC	LPMTPILE	DEG_SCF_FBW7_2	0.2222
p.A434T	SIDM00574	Glioblastoma	GDSC	LPMTPILE	DEG_SCF_FBW7_2	0.7139
p.A434T	no-10	central_nervous_system	COSMIC	LPMTPILE	DEG_SCF_FBW7_2	0.7139
p.T442I	SIDM00982	Glioblastoma	GDSC	LPMTPILE	DEG_SCF_FBW7_2	0.1667
p.T442I	ACH-000323	Brain Cancer	CCLE	LPMTPILE	DEG_SCF_FBW7_2	0.1667
p.T442I	42-MG-BA	central_nervous_system	COSMIC	LPMTPILE	DEG_SCF_FBW7_2	0.1667
p.M441K	ACH-001523	Skin Cancer	CCLE	LPMTPILE	DEG_SCF_FBW7_2	0.1944
p.A424T	ACH-001605	Brain Cancer	CCLE	LPMTPILE	DEG_SCF_FBW7_2	0.1944
p.A424T	no-10	central_nervous_system	COSMIC	LPMTPILE	DEG_SCF_FBW7_2	0.1944
p.T432I	42-MG-BA	central_nervous_system	COSMIC	LPMTPILE	DEG_SCF_FBW7_2	0.8189

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IZ21	Phosphatase and actin regulator 4	DEG_SCF_FBW7_2	429:436	LPMTPILE	FBXW7	0.9924	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons