DegronMD - Q9Y5F8(PCDHGB7)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S434F	TCGA-86-7713	LUAD	TCGA	PLSSS	DEG_SPOP_SBC_1	431:435	Mutation altering degron motif	0.7982
p.S434F	DO24712	LUAD	ICGC	PLSSS	DEG_SPOP_SBC_1	431:435	Mutation altering degron motif	0.7982
p.A423T	TCGA-AX-A2HC	UCEC	TCGA	PLSSS	DEG_SPOP_SBC_1	431:435	Mutation rewiring degron network	0.1111
p.A423T	DO41572	UCEC	ICGC	PLSSS	DEG_SPOP_SBC_1	431:435	Mutation rewiring degron network	0.1111
p.R427K	TCGA-BQ-7056	KIRP	TCGA	PLSSS	DEG_SPOP_SBC_1	431:435	Mutation rewiring degron network	0.2222
p.R427K	DO20872	KIRP	ICGC	PLSSS	DEG_SPOP_SBC_1	431:435	Mutation rewiring degron network	0.2222
p.E687K	TCGA-CR-7382	HNSC	TCGA	PTPSDS	DEG_SCF_FBW7_1	679:684	Mutation rewiring degron network	0.25
p.E687K	DO14171	HNSC	ICGC	PTPSDS	DEG_SCF_FBW7_1	679:684	Mutation rewiring degron network	0.25
p.P431L	TCGA-E6-A1LX	UCEC	TCGA	PLSSS	DEG_SPOP_SBC_1	431:435	Mutation altering degron motif	0.7582
p.P431L	DO41020	UCEC	ICGC	PLSSS	DEG_SPOP_SBC_1	431:435	Mutation altering degron motif	0.7582
p.V445I	TCGA-HU-A4G8	STAD	TCGA	PLSSS	DEG_SPOP_SBC_1	431:435	Mutation rewiring degron network	0.0556
p.V445I	DO47819	STAD	ICGC	PLSSS	DEG_SPOP_SBC_1	431:435	Mutation rewiring degron network	0.0556
p.D677V	DO230312	COCA	ICGC	PTPSDS	DEG_SCF_FBW7_1	679:684	Mutation rewiring degron network	0.2778
p.T439A	DO234363	ESAD	ICGC	PLSSS	DEG_SPOP_SBC_1	431:435	Mutation rewiring degron network	0.2222
p.L432S	DO218547	GACA	ICGC	PLSSS	DEG_SPOP_SBC_1	431:435	Mutation altering degron motif	0.6556
p.P895T	DO233115	GACA	ICGC	DYR	CBL_MET	887:889	Mutation rewiring degron network	0.1667
p.V885M	DO25554	LUAD	ICGC	DYR	CBL_MET	887:889	Mutation rewiring degron network	0.2778
p.V885M	SLVL	haematopoietic and lymphoid tissue	COSMIC	DYR	CBL_MET	887:889	Mutation rewiring degron network	0.2778
p.V892G	DO28089	OV	ICGC	DYR	CBL_MET	887:889	Mutation rewiring degron network	0.25
p.T881A	DO48918	PBCA	ICGC	DYR	CBL_MET	887:889	Mutation rewiring degron network	0.1667
p.R889H	DO41871	UCEC	ICGC	DYR	CBL_MET	887:889	Mutation altering degron motif	0.8244
p.R889C	DO42568	UCEC	ICGC	DYR	CBL_MET	887:889	Mutation altering degron motif	0.8301
p.S676N	SIDM00946	T-Lymphoblastic Leukemia	GDSC	PTPSDS	DEG_SCF_FBW7_1	679:684	Mutation rewiring degron network	0.25
p.S676N	ACH-000981	Leukemia	CCLE	PTPSDS	DEG_SCF_FBW7_1	679:684	Mutation rewiring degron network	0.25
p.S676N	DND-41	haematopoietic and lymphoid tissue	COSMIC	PTPSDS	DEG_SCF_FBW7_1	679:684	Mutation rewiring degron network	0.25
p.D674Y	SIDM01181	Hepatocellular Carcinoma	GDSC	PTPSDS	DEG_SCF_FBW7_1	679:684	Mutation rewiring degron network	0.1944
p.D674Y	ACH-000221	Liver Cancer	CCLE	PTPSDS	DEG_SCF_FBW7_1	679:684	Mutation rewiring degron network	0.1944
p.D674Y	SNU-398	liver	COSMIC	PTPSDS	DEG_SCF_FBW7_1	679:684	Mutation rewiring degron network	0.1944
p.L440M	SIDM00217	Colorectal Carcinoma	GDSC	PLSSS	DEG_SPOP_SBC_1	431:435	Mutation rewiring degron network	0.1944
p.L440M	ACH-000999	Colon/Colorectal Cancer	CCLE	PLSSS	DEG_SPOP_SBC_1	431:435	Mutation rewiring degron network	0.1944
p.L440M	SNU-1040	large intestine	COSMIC	PLSSS	DEG_SPOP_SBC_1	431:435	Mutation rewiring degron network	0.1944
p.D674E	SIDM00008	Ovarian Carcinoma	GDSC	PTPSDS	DEG_SCF_FBW7_1	679:684	Mutation rewiring degron network	0.1944
p.D674E	ACH-000796	Ovarian Cancer	CCLE	PTPSDS	DEG_SCF_FBW7_1	679:684	Mutation rewiring degron network	0.1944
p.T437I	SIDM01475	Ovarian Carcinoma	GDSC	PLSSS	DEG_SPOP_SBC_1	431:435	Mutation rewiring degron network	0.2778
p.I442M	ACH-001461	Colon/Colorectal Cancer	CCLE	PLSSS	DEG_SPOP_SBC_1	431:435	Mutation rewiring degron network	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PCDHGB7

UniProt ID: Q9Y5F8

Entrez ID: 56099

Protein name: Protocadherin gamma-B7 (PCDH-gamma-B7)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PCDHGB7 in