DegronMD

Uniprot ID: Q9Y5F8

Source protein: Protocadherin gamma-B7

Source gene: PCDHGB7

Class: DEG_SCF_FBW7_1

Location: 679:684

E3 ligase: FBXW7

DEGRON score: 0.9863

ASA_SCORE: 81.3333

COIL: 0.8787

CONS_SCORE: 0.5494

DSS_SCORE: 0.3307

HELIX: 0.0917

FCONS_SCORE: 1.2763

RIG_SCORE: 0.7043

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E687K	TCGA-CR-7382	HNSC	TCGA	PTPSDS	DEG_SCF_FBW7_1	0.25
p.E687K	DO14171	HNSC	ICGC	PTPSDS	DEG_SCF_FBW7_1	0.25
p.D677V	DO230312	COCA	ICGC	PTPSDS	DEG_SCF_FBW7_1	0.2778
p.S676N	SIDM00946	T-Lymphoblastic Leukemia	GDSC	PTPSDS	DEG_SCF_FBW7_1	0.25
p.S676N	ACH-000981	Leukemia	CCLE	PTPSDS	DEG_SCF_FBW7_1	0.25
p.S676N	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	PTPSDS	DEG_SCF_FBW7_1	0.25
p.D674Y	SIDM01181	Hepatocellular Carcinoma	GDSC	PTPSDS	DEG_SCF_FBW7_1	0.1944
p.D674Y	ACH-000221	Liver Cancer	CCLE	PTPSDS	DEG_SCF_FBW7_1	0.1944
p.D674Y	SNU-398	liver	COSMIC	PTPSDS	DEG_SCF_FBW7_1	0.1944
p.D674E	SIDM00008	Ovarian Carcinoma	GDSC	PTPSDS	DEG_SCF_FBW7_1	0.1944
p.D674E	ACH-000796	Ovarian Cancer	CCLE	PTPSDS	DEG_SCF_FBW7_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y5F8	Protocadherin gamma-B7	DEG_SCF_FBW7_1	679:684	PTPSDS	FBXW7	0.9863	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons