DegronMD - Q6AI39(BICRAL)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R300M	SIDM01016	T-Lymphoblastic Leukemia	GDSC	LAPNSNKVPINI	DEG_ODPH_VHL_1	302:313	Mutation rewiring degron network	0.2778
p.R300M	SIDM01263	T-Lymphoblastic Leukemia	GDSC	LAPNSNKVPINI	DEG_ODPH_VHL_1	302:313	Mutation rewiring degron network	0.2778
p.R300M	Jurkat	haematopoietic and lymphoid tissue	COSMIC	LAPNSNKVPINI	DEG_ODPH_VHL_1	302:313	Mutation rewiring degron network	0.2778
p.R724Q	SIDM00513	Non-Small Cell Lung Carcinoma	GDSC	VTPDKS	DEG_SCF_FBW7_1	716:721	Mutation rewiring degron network	0.25
p.R724Q	SIDM01653	Non-Cancerous	GDSC	VTPDKS	DEG_SCF_FBW7_1	716:721	Mutation rewiring degron network	0.25
p.R724Q	SIDM00207	Glioblastoma	GDSC	VTPDKS	DEG_SCF_FBW7_1	716:721	Mutation rewiring degron network	0.25
p.R724G	SIDM00797	Melanoma	GDSC	VTPDKS	DEG_SCF_FBW7_1	716:721	Mutation rewiring degron network	0.25
p.R724G	A2058	skin	COSMIC	VTPDKS	DEG_SCF_FBW7_1	716:721	Mutation rewiring degron network	0.25
p.Q707R	SIDM00282	Colorectal Carcinoma	GDSC	VTPDKS	DEG_SCF_FBW7_1	716:721	Mutation rewiring degron network	0.0833
p.Q707R	CW-2	large intestine	COSMIC	VTPDKS	DEG_SCF_FBW7_1	716:721	Mutation rewiring degron network	0.0833
p.S80G	SIDM00549	B-Lymphoblastic Leukemia	GDSC	PLSSS	DEG_SPOP_SBC_1	77:81	Mutation altering degron motif	0.6993
p.S80G	SIDM01659	Kidney Carcinoma	GDSC	PLSSS	DEG_SPOP_SBC_1	77:81	Mutation altering degron motif	0.6993
p.G75A	SIDM00448	B-Cell Non-Hodgkin's Lymphoma	GDSC	PLSSS	DEG_SPOP_SBC_1	77:81	Mutation rewiring degron network	0.2778
p.G75A	RC-K8	haematopoietic and lymphoid tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	77:81	Mutation rewiring degron network	0.2778

Kaplan plot for BICRAL in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

BICRAL

UniProt ID: Q6AI39

Entrez ID: 23506

Protein name: BRD4-interacting chromatin-remodeling complex-associated protein-like (Glioma tumor suppressor candidate region gene 1 protein-like)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for BICRAL in