DegronMD

Uniprot ID: Q6AI39

Source protein: BRD4-interacting chromatin-remodeling complex-associated protein-like

Source gene: BICRAL

Class: DEG_SCF_FBW7_1

Location: 716:721

E3 ligase: FBXW7

DEGRON score: 0.9951

ASA_SCORE: 71.9

COIL: 0.8267

CONS_SCORE: 0.5895

DSS_SCORE: 0.5197

HELIX: 0.1173

FCONS_SCORE: 1.0785

RIG_SCORE: 0.72

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R724Q	SIDM00513	Non-Small Cell Lung Carcinoma	GDSC	VTPDKS	DEG_SCF_FBW7_1	0.25
p.R724Q	SIDM01653	Non-Cancerous	GDSC	VTPDKS	DEG_SCF_FBW7_1	0.25
p.R724Q	SIDM00207	Glioblastoma	GDSC	VTPDKS	DEG_SCF_FBW7_1	0.25
p.R724G	SIDM00797	Melanoma	GDSC	VTPDKS	DEG_SCF_FBW7_1	0.25
p.R724G	A2058	skin	COSMIC	VTPDKS	DEG_SCF_FBW7_1	0.25
p.Q707R	SIDM00282	Colorectal Carcinoma	GDSC	VTPDKS	DEG_SCF_FBW7_1	0.0833
p.Q707R	CW-2	large_intestine	COSMIC	VTPDKS	DEG_SCF_FBW7_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6AI39	BRD4-interacting chromatin-remodeling complex-associated protein-like	DEG_SCF_FBW7_1	716:721	VTPDKS	FBXW7	0.9951	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons