DegronMD

Uniprot ID: Q6AI39

Source protein: BRD4-interacting chromatin-remodeling complex-associated protein-like

Source gene: BICRAL

Class: DEG_ODPH_VHL_1

Location: 302:313

E3 ligase: VHL

DEGRON score: 0.987

ASA_SCORE: 102.8583

COIL: 0.9513

CONS_SCORE: 0.6078

DSS_SCORE: 0.4231

HELIX: 0.0162

FCONS_SCORE: 0.951

RIG_SCORE: 0.7294

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R300M	SIDM01016	T-Lymphoblastic Leukemia	GDSC	LAPNSNKVPINI	DEG_ODPH_VHL_1	0.2778
p.R300M	SIDM01263	T-Lymphoblastic Leukemia	GDSC	LAPNSNKVPINI	DEG_ODPH_VHL_1	0.2778
p.R300M	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	LAPNSNKVPINI	DEG_ODPH_VHL_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6AI39	BRD4-interacting chromatin-remodeling complex-associated protein-like	DEG_ODPH_VHL_1	302:313	LAPNSNKVPINI	VHL	0.987	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons