DegronMD - P11388(TOP2A)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E1380K	TCGA-3C-AALI	BRCA	TCGA	PLSSS	DEG_SPOP_SBC_1	1389:1393	Mutation rewiring degron network	0.0833
p.E1380K	DO219589	BRCA	ICGC	PLSSS	DEG_SPOP_SBC_1	1389:1393	Mutation rewiring degron network	0.0833
p.E1380K	SIDM00946	T-Lymphoblastic Leukemia	GDSC	PLSSS	DEG_SPOP_SBC_1	1389:1393	Mutation rewiring degron network	0.0833
p.E1380K	ACH-000981	Leukemia	CCLE	PLSSS	DEG_SPOP_SBC_1	1389:1393	Mutation rewiring degron network	0.0833
p.E1380K	DND-41	haematopoietic and lymphoid tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	1389:1393	Mutation rewiring degron network	0.0833
p.I921T	TCGA-55-7907	LUAD	TCGA	LAPNQYVISGEVAI	DEG_ODPH_VHL_1	902:915	Mutation rewiring degron network	0.1667
p.I921T	DO25396	LUAD	ICGC	LAPNQYVISGEVAI	DEG_ODPH_VHL_1	902:915	Mutation rewiring degron network	0.1667
p.E922D	TCGA-AG-3892	READ	TCGA	LAPNQYVISGEVAI	DEG_ODPH_VHL_1	902:915	Mutation rewiring degron network	0.1389
p.E922D	DO36394	READ	ICGC	LAPNQYVISGEVAI	DEG_ODPH_VHL_1	902:915	Mutation rewiring degron network	0.1389
p.P371S	TCGA-EB-A85J	SKCM	TCGA	TKENM	DEG_APCC_KENBOX_2	377:381	Mutation rewiring degron network	0.1667
p.P371S	DO50297	SKCM	ICGC	TKENM	DEG_APCC_KENBOX_2	377:381	Mutation rewiring degron network	0.1667
p.K1385N	TCGA-EE-A29L	SKCM	TCGA	PLSSS	DEG_SPOP_SBC_1	1389:1393	Mutation blocking ubiquitination signal	0.6667
p.K1385N	DO37835	SKCM	ICGC	PLSSS	DEG_SPOP_SBC_1	1389:1393	Mutation blocking ubiquitination signal	0.6667
p.P1394T	TCGA-FS-A1ZB	SKCM	TCGA	PLSSS	DEG_SPOP_SBC_1	1389:1393	Mutation rewiring degron network	0.3056
p.P1394T	DO37886	SKCM	ICGC	PLSSS	DEG_SPOP_SBC_1	1389:1393	Mutation rewiring degron network	0.3056
p.D1382H	TCGA-JW-A5VL	CESC	TCGA	PLSSS	DEG_SPOP_SBC_1	1389:1393	Mutation rewiring degron network	0.1389
p.D1382H	DO49976	CESC	ICGC	PLSSS	DEG_SPOP_SBC_1	1389:1393	Mutation rewiring degron network	0.1389
p.D1382H	DO234314	ESAD	ICGC	PLSSS	DEG_SPOP_SBC_1	1389:1393	Mutation rewiring degron network	0.1389
p.S387R	TCGA-LN-A5U5	ESCA	TCGA	TKENM	DEG_APCC_KENBOX_2	377:381	Mutation rewiring degron network	0.1667
p.N894D	DO233804	GACA	ICGC	LAPNQYVISGEVAI	DEG_ODPH_VHL_1	902:915	Mutation rewiring degron network	0.1111
p.P1395T	DO231793	LINC	ICGC	PLSSS	DEG_SPOP_SBC_1	1389:1393	Mutation rewiring degron network	0.2778
p.P385A	SIDM00845	Burkitt's Lymphoma	GDSC	TKENM	DEG_APCC_KENBOX_2	377:381	Mutation rewiring degron network	0.2222
p.P385A	ACH-000992	Head and Neck Cancer	CCLE	TKENM	DEG_APCC_KENBOX_2	377:381	Mutation rewiring degron network	0.2222
p.A903D	SIDM01259	B-Lymphoblastic Leukemia	GDSC	LAPNQYVISGEVAI	DEG_ODPH_VHL_1	902:915	Mutation altering degron motif	0.7793
p.A903D	ACH-001669	Leukemia	CCLE	LAPNQYVISGEVAI	DEG_ODPH_VHL_1	902:915	Mutation altering degron motif	0.7793
p.A903D	ACH-002238	Leukemia	CCLE	LAPNQYVISGEVAI	DEG_ODPH_VHL_1	902:915	Mutation altering degron motif	0.7793
p.A903D	GR-ST	haematopoietic and lymphoid tissue	COSMIC	LAPNQYVISGEVAI	DEG_ODPH_VHL_1	902:915	Mutation altering degron motif	0.7793
p.K893R	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	LAPNQYVISGEVAI	DEG_ODPH_VHL_1	902:915	Mutation blocking ubiquitination signal	0.5278
p.P1394R	ACH-001956	Bone Cancer	CCLE	PLSSS	DEG_SPOP_SBC_1	1389:1393	Mutation rewiring degron network	0.3056

Kaplan plot for TOP2A in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TOP2A

UniProt ID: P11388

Entrez ID: 7153

Protein name: DNA topoisomerase 2-alpha (EC 5.6.2.2) (DNA topoisomerase II, alpha isozyme)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TOP2A in