DegronMD

Uniprot ID: P11388

Source protein: DNA topoisomerase 2-alpha

Source gene: TOP2A

Class: DEG_ODPH_VHL_1

Location: 902:915

E3 ligase: VHL

DEGRON score: 0.5229

ASA_SCORE: 48.7857

COIL: 0.2548

CONS_SCORE: 0.3002

DSS_SCORE: 0.1643

HELIX: 0.0078

FCONS_SCORE: 0.6522

RIG_SCORE: 0.8426

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I921T	TCGA-55-7907	LUAD	TCGA	LAPNQYVISGEVAI	DEG_ODPH_VHL_1	0.1667
p.I921T	DO25396	LUAD	ICGC	LAPNQYVISGEVAI	DEG_ODPH_VHL_1	0.1667
p.E922D	TCGA-AG-3892	READ	TCGA	LAPNQYVISGEVAI	DEG_ODPH_VHL_1	0.1389
p.E922D	DO36394	READ	ICGC	LAPNQYVISGEVAI	DEG_ODPH_VHL_1	0.1389
p.N894D	DO233804	GACA	ICGC	LAPNQYVISGEVAI	DEG_ODPH_VHL_1	0.1111
p.A903D	SIDM01259	B-Lymphoblastic Leukemia	GDSC	LAPNQYVISGEVAI	DEG_ODPH_VHL_1	0.7793
p.A903D	ACH-001669	Leukemia	CCLE	LAPNQYVISGEVAI	DEG_ODPH_VHL_1	0.7793
p.A903D	ACH-002238	Leukemia	CCLE	LAPNQYVISGEVAI	DEG_ODPH_VHL_1	0.7793
p.A903D	GR-ST	haematopoietic_and_lymphoid_tissue	COSMIC	LAPNQYVISGEVAI	DEG_ODPH_VHL_1	0.7793
p.K893R	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	LAPNQYVISGEVAI	DEG_ODPH_VHL_1	0.5278

Drug responses associated with TOP2A mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00918	OV\|ovary	p.S1392* (No)	GDSC	Etoposide	79.2721
SIDM00190	SKCM\|melanoma	p.V255I (No)	GDSC	Etoposide	4.873
SIDM00951	LAML\|acute_myeloid_leukaemia	p.R675* (No)	GDSC	Etoposide	0.4151
SIDM00145	ALL\|lymphoblastic_leukemia	p.S1491F (No)	GDSC	Etoposide	0.2463
SIDM00145	ALL\|lymphoblastic_leukemia	p.R268H (No)	GDSC	Etoposide	0.2463
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.R1435fs*13 (No)	GDSC	Etoposide	6.9919
SIDM00654	SCLC\|lung_small_cell_carcinoma	p.Q1453fs*3 (No)	GDSC	Etoposide	0.5619
SIDM00104	MESO\|mesothelioma	p.K1110E (No)	GDSC	Etoposide	2.9539
SIDM00956	ESCA\|oesophagus	p.K893R (Yes)	GDSC	Etoposide	7.1187
SIDM01007	ALL\|lymphoblastic_leukemia	p.V1506M (No)	GDSC	Etoposide	21.8046
SIDM01007	ALL\|lymphoblastic_leukemia	p.P1457L (No)	GDSC	Etoposide	21.8046
SIDM01007	ALL\|lymphoblastic_leukemia	p.E626K (No)	GDSC	Etoposide	21.8046
SIDM01007	ALL\|lymphoblastic_leukemia	p.A588S (No)	GDSC	Etoposide	21.8046
SIDM01007	ALL\|lymphoblastic_leukemia	p.D222N (No)	GDSC	Etoposide	21.8046
SIDM00666	LGG\|glioma	p.T930I (No)	GDSC	Etoposide	0.976
SIDM00844	UNCLASSIFIED\|Burkitt_lymphoma	p.G1192R (No)	GDSC	Etoposide	9.0519
SIDM00690	HNSC\|head_and_neck	p.G1197A (No)	GDSC	Etoposide	0.6063
SIDM00938	BRCA\|breast	p.S1449C (No)	GDSC	Etoposide	0.6923
SIDM01090	COREAD\|large_intestine	p.K1489E (No)	GDSC	Etoposide	0.5276
SIDM01090	COREAD\|large_intestine	p.Y613C (No)	GDSC	Etoposide	0.5276
SIDM01259	ALL\|lymphoblastic_leukemia	p.T1205fs*19 (No)	GDSC	Etoposide	8.5228
SIDM01020	MM\|myeloma	p.A318P (No)	GDSC	Etoposide	4.4968
SIDM00252	UNCLASSIFIED\|biliary_tract	p.R635H (No)	GDSC	Etoposide	33.2918
SIDM00252	UNCLASSIFIED\|biliary_tract	p.T530A (No)	GDSC	Etoposide	33.2918
SIDM00251	STAD\|stomach	p.M102fs*14 (No)	GDSC	Etoposide	47.1095
SIDM00792	SCLC\|lung_small_cell_carcinoma	p.N774I (No)	GDSC	Etoposide	10.4314
SIDM00438	UNCLASSIFIED\|B_cell_leukemia	p.T1205fs*19 (No)	GDSC	Etoposide	21.6344
SIDM00946	ALL\|T_cell_leukemia	p.E1380K (No)	GDSC	Etoposide	0.7725
SIDM00946	ALL\|T_cell_leukemia	p.T357I (No)	GDSC	Etoposide	0.7725
SIDM00946	ALL\|T_cell_leukemia	p.L231P (No)	GDSC	Etoposide	0.7725
SIDM00602	STAD\|stomach	p.T1205fs*19 (No)	GDSC	Etoposide	4.9204
SIDM00313	UNCLASSIFIED\|Hodgkin_lymphoma	p.G1216C (No)	GDSC	Etoposide	11.9554
SIDM00794	UNCLASSIFIED\|skin_other	p.Q35R (No)	GDSC	Etoposide	2.1041
SIDM00783	COREAD\|large_intestine	p.Q657fs*4 (No)	GDSC	Etoposide	0.8065
SIDM00599	UNCLASSIFIED\|osteosarcoma	p.V776L (No)	GDSC	Etoposide	1.043
SIDM01096	COREAD\|large_intestine	p.K1110E (No)	GDSC	Etoposide	1.888
SIDM00699	SCLC\|lung_small_cell_carcinoma	p.P643T (No)	GDSC	Etoposide	7.4048
SIDM00363	LAML\|acute_myeloid_leukaemia	p.L944S (No)	GDSC	Etoposide	95.1444
SIDM00886	DLBC\|B_cell_lymphoma	p.S1428P (No)	GDSC	Etoposide	6.8141
SIDM00739	LUAD\|lung_NSCLC_adenocarcinoma	p.K1196I (No)	GDSC	Etoposide	1.8655
SIDM00263	UNCLASSIFIED\|ewings_sarcoma	p.G1198R (No)	GDSC	Etoposide	38.1681
SIDM00257	NB\|neuroblastoma	p.P786H (No)	GDSC	Etoposide	1.7136
SIDM01090	COREAD\|large_intestine	p.T620fs*7 (No)	GDSC	Etoposide	0.5276
SIDM00143	SCLC\|lung_small_cell_carcinoma	p.D152Y (No)	GDSC	Etoposide	2.0328
SIDM00427	UNCLASSIFIED\|rhabdomyosarcoma	p.N774I (No)	GDSC	Etoposide	0.1621
SIDM00789	COREAD\|large_intestine	p.L326S (No)	GDSC	Etoposide	8.7985
SIDM00534	COREAD\|large_intestine	p.S1425F (No)	GDSC	Etoposide	11.7804
SIDM00534	COREAD\|large_intestine	p.S527* (No)	GDSC	Etoposide	11.7804
SIDM00680	COREAD\|large_intestine	p.T1205fs*19 (No)	GDSC	Etoposide	1.3046
SIDM00963	BRCA\|breast	p.V1097L (No)	GDSC	Etoposide	113.841
SIDM00412	UNCLASSIFIED\|lymphoid_neoplasm_other	p.R1435fs*13 (No)	GDSC	Etoposide	2.9138
SIDM00663	SKCM\|melanoma	p.S1337L (No)	GDSC	Etoposide	6.6804
SIDM01116	UNCLASSIFIED\|lung_NSCLC_large_cell	p.V1001L (No)	GDSC	Etoposide	1.7035
SIDM00683	PRAD\|prostate	p.R1435fs*13 (No)	GDSC	Etoposide	10.7002
SIDM00142	UCEC\|endometrium	p.R1435fs*13 (No)	GDSC	Etoposide	11.6305
SIDM01080	HNSC\|head_and_neck	p.N774I (No)	GDSC	Etoposide	0.8558
SIDM00040	STAD\|stomach	p.V68I (No)	GDSC	Etoposide	4.4022
SIDM01113	UNCLASSIFIED\|soft_tissue_other	p.V364L (No)	GDSC	Etoposide	0.0552
SIDM00339	LUAD\|lung_NSCLC_adenocarcinoma	p.S1337L (No)	GDSC	Etoposide	1.9732
SIDM01259	ALL\|lymphoblastic_leukemia	p.A903D (Yes)	GDSC	Etoposide	8.5228
SIDM01027	ESCA\|oesophagus	p.P716R (No)	GDSC	Etoposide	1.9148
SIDM00423	DLBC\|B_cell_lymphoma	p.G1197E (No)	GDSC	Etoposide	0.3217
SIDM00374	DLBC\|B_cell_lymphoma	p.D213G (No)	GDSC	Etoposide	1.7691
SIDM00054	PAAD\|pancreas	p.S1361F (No)	GDSC	Etoposide	0.6636
SIDM00531	PAAD\|pancreas	p.H290Q (No)	GDSC	Etoposide	1.1689
SIDM01010	UNCLASSIFIED\|anaplastic_large_cell_lymphoma	p.R1435G (No)	GDSC	Etoposide	4.1415
SIDM00118	COREAD\|large_intestine	p.Q1206H (No)	GDSC	Etoposide	1.0944
SIDM00661	DLBC\|B_cell_lymphoma	p.R1435fs*13 (No)	GDSC	Etoposide	16.3821

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LAPNQYVISGEVAI

Degron related mutations and impact score

Drug responses associated with TOP2A mutations

All proteins holding degron of LAPNQYVISGEVAI

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P11388	DNA topoisomerase 2-alpha	DEG_ODPH_VHL_1	902:915	LAPNQYVISGEVAI	VHL	0.5229	More...