DegronMD

Uniprot ID: P11388

Source protein: DNA topoisomerase 2-alpha

Source gene: TOP2A

Class: DEG_APCC_KENBOX_2

Location: 377:381

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8765

ASA_SCORE: 76.62

COIL: 0.6236

CONS_SCORE: 0.6722

DSS_SCORE: 0.4505

HELIX: 0.2108

FCONS_SCORE: 1.2631

RIG_SCORE: 0.7829

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P371S	TCGA-EB-A85J	SKCM	TCGA	TKENM	DEG_APCC_KENBOX_2	0.1667
p.P371S	DO50297	SKCM	ICGC	TKENM	DEG_APCC_KENBOX_2	0.1667
p.S387R	TCGA-LN-A5U5	ESCA	TCGA	TKENM	DEG_APCC_KENBOX_2	0.1667
p.P385A	SIDM00845	Burkitt's Lymphoma	GDSC	TKENM	DEG_APCC_KENBOX_2	0.2222
p.P385A	ACH-000992	Head and Neck Cancer	CCLE	TKENM	DEG_APCC_KENBOX_2	0.2222

Drug responses associated with TOP2A mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00918	OV\|ovary	p.S1392* (No)	GDSC	Etoposide	79.2721
SIDM00190	SKCM\|melanoma	p.V255I (No)	GDSC	Etoposide	4.873
SIDM00951	LAML\|acute_myeloid_leukaemia	p.R675* (No)	GDSC	Etoposide	0.4151
SIDM00145	ALL\|lymphoblastic_leukemia	p.S1491F (No)	GDSC	Etoposide	0.2463
SIDM00145	ALL\|lymphoblastic_leukemia	p.R268H (No)	GDSC	Etoposide	0.2463
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.R1435fs*13 (No)	GDSC	Etoposide	6.9919
SIDM00654	SCLC\|lung_small_cell_carcinoma	p.Q1453fs*3 (No)	GDSC	Etoposide	0.5619
SIDM00104	MESO\|mesothelioma	p.K1110E (No)	GDSC	Etoposide	2.9539
SIDM00956	ESCA\|oesophagus	p.K893R (No)	GDSC	Etoposide	7.1187
SIDM01007	ALL\|lymphoblastic_leukemia	p.V1506M (No)	GDSC	Etoposide	21.8046
SIDM01007	ALL\|lymphoblastic_leukemia	p.P1457L (No)	GDSC	Etoposide	21.8046
SIDM01007	ALL\|lymphoblastic_leukemia	p.E626K (No)	GDSC	Etoposide	21.8046
SIDM01007	ALL\|lymphoblastic_leukemia	p.A588S (No)	GDSC	Etoposide	21.8046
SIDM01007	ALL\|lymphoblastic_leukemia	p.D222N (No)	GDSC	Etoposide	21.8046
SIDM00666	LGG\|glioma	p.T930I (No)	GDSC	Etoposide	0.976
SIDM00844	UNCLASSIFIED\|Burkitt_lymphoma	p.G1192R (No)	GDSC	Etoposide	9.0519
SIDM00690	HNSC\|head_and_neck	p.G1197A (No)	GDSC	Etoposide	0.6063
SIDM00938	BRCA\|breast	p.S1449C (No)	GDSC	Etoposide	0.6923
SIDM01090	COREAD\|large_intestine	p.K1489E (No)	GDSC	Etoposide	0.5276
SIDM01090	COREAD\|large_intestine	p.Y613C (No)	GDSC	Etoposide	0.5276
SIDM01259	ALL\|lymphoblastic_leukemia	p.T1205fs*19 (No)	GDSC	Etoposide	8.5228
SIDM01020	MM\|myeloma	p.A318P (No)	GDSC	Etoposide	4.4968
SIDM00252	UNCLASSIFIED\|biliary_tract	p.R635H (No)	GDSC	Etoposide	33.2918
SIDM00252	UNCLASSIFIED\|biliary_tract	p.T530A (No)	GDSC	Etoposide	33.2918
SIDM00251	STAD\|stomach	p.M102fs*14 (No)	GDSC	Etoposide	47.1095
SIDM00792	SCLC\|lung_small_cell_carcinoma	p.N774I (No)	GDSC	Etoposide	10.4314
SIDM00438	UNCLASSIFIED\|B_cell_leukemia	p.T1205fs*19 (No)	GDSC	Etoposide	21.6344
SIDM00946	ALL\|T_cell_leukemia	p.E1380K (No)	GDSC	Etoposide	0.7725
SIDM00946	ALL\|T_cell_leukemia	p.T357I (No)	GDSC	Etoposide	0.7725
SIDM00946	ALL\|T_cell_leukemia	p.L231P (No)	GDSC	Etoposide	0.7725
SIDM00602	STAD\|stomach	p.T1205fs*19 (No)	GDSC	Etoposide	4.9204
SIDM00313	UNCLASSIFIED\|Hodgkin_lymphoma	p.G1216C (No)	GDSC	Etoposide	11.9554
SIDM00794	UNCLASSIFIED\|skin_other	p.Q35R (No)	GDSC	Etoposide	2.1041
SIDM00783	COREAD\|large_intestine	p.Q657fs*4 (No)	GDSC	Etoposide	0.8065
SIDM00599	UNCLASSIFIED\|osteosarcoma	p.V776L (No)	GDSC	Etoposide	1.043
SIDM01096	COREAD\|large_intestine	p.K1110E (No)	GDSC	Etoposide	1.888
SIDM00699	SCLC\|lung_small_cell_carcinoma	p.P643T (No)	GDSC	Etoposide	7.4048
SIDM00363	LAML\|acute_myeloid_leukaemia	p.L944S (No)	GDSC	Etoposide	95.1444
SIDM00886	DLBC\|B_cell_lymphoma	p.S1428P (No)	GDSC	Etoposide	6.8141
SIDM00739	LUAD\|lung_NSCLC_adenocarcinoma	p.K1196I (No)	GDSC	Etoposide	1.8655
SIDM00263	UNCLASSIFIED\|ewings_sarcoma	p.G1198R (No)	GDSC	Etoposide	38.1681
SIDM00257	NB\|neuroblastoma	p.P786H (No)	GDSC	Etoposide	1.7136
SIDM01090	COREAD\|large_intestine	p.T620fs*7 (No)	GDSC	Etoposide	0.5276
SIDM00143	SCLC\|lung_small_cell_carcinoma	p.D152Y (No)	GDSC	Etoposide	2.0328
SIDM00427	UNCLASSIFIED\|rhabdomyosarcoma	p.N774I (No)	GDSC	Etoposide	0.1621
SIDM00789	COREAD\|large_intestine	p.L326S (No)	GDSC	Etoposide	8.7985
SIDM00534	COREAD\|large_intestine	p.S1425F (No)	GDSC	Etoposide	11.7804
SIDM00534	COREAD\|large_intestine	p.S527* (No)	GDSC	Etoposide	11.7804
SIDM00680	COREAD\|large_intestine	p.T1205fs*19 (No)	GDSC	Etoposide	1.3046
SIDM00963	BRCA\|breast	p.V1097L (No)	GDSC	Etoposide	113.841
SIDM00412	UNCLASSIFIED\|lymphoid_neoplasm_other	p.R1435fs*13 (No)	GDSC	Etoposide	2.9138
SIDM00663	SKCM\|melanoma	p.S1337L (No)	GDSC	Etoposide	6.6804
SIDM01116	UNCLASSIFIED\|lung_NSCLC_large_cell	p.V1001L (No)	GDSC	Etoposide	1.7035
SIDM00683	PRAD\|prostate	p.R1435fs*13 (No)	GDSC	Etoposide	10.7002
SIDM00142	UCEC\|endometrium	p.R1435fs*13 (No)	GDSC	Etoposide	11.6305
SIDM01080	HNSC\|head_and_neck	p.N774I (No)	GDSC	Etoposide	0.8558
SIDM00040	STAD\|stomach	p.V68I (No)	GDSC	Etoposide	4.4022
SIDM01113	UNCLASSIFIED\|soft_tissue_other	p.V364L (No)	GDSC	Etoposide	0.0552
SIDM00339	LUAD\|lung_NSCLC_adenocarcinoma	p.S1337L (No)	GDSC	Etoposide	1.9732
SIDM01259	ALL\|lymphoblastic_leukemia	p.A903D (No)	GDSC	Etoposide	8.5228
SIDM01027	ESCA\|oesophagus	p.P716R (No)	GDSC	Etoposide	1.9148
SIDM00423	DLBC\|B_cell_lymphoma	p.G1197E (No)	GDSC	Etoposide	0.3217
SIDM00374	DLBC\|B_cell_lymphoma	p.D213G (No)	GDSC	Etoposide	1.7691
SIDM00054	PAAD\|pancreas	p.S1361F (No)	GDSC	Etoposide	0.6636
SIDM00531	PAAD\|pancreas	p.H290Q (No)	GDSC	Etoposide	1.1689
SIDM01010	UNCLASSIFIED\|anaplastic_large_cell_lymphoma	p.R1435G (No)	GDSC	Etoposide	4.1415
SIDM00118	COREAD\|large_intestine	p.Q1206H (No)	GDSC	Etoposide	1.0944
SIDM00661	DLBC\|B_cell_lymphoma	p.R1435fs*13 (No)	GDSC	Etoposide	16.3821

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P11388	DNA topoisomerase 2-alpha	DEG_APCC_KENBOX_2	377:381	TKENM	APC,CDC20,FZR1	0.8765	More...
Q02880	DNA topoisomerase 2-beta	DEG_APCC_KENBOX_2	398:402	TKENM	APC,CDC20,FZR1	0.7296	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: TKENM

Degron related mutations and impact score

Drug responses associated with TOP2A mutations

All proteins holding degron of TKENM