DegronMD - Q02880(TOP2B)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S391F	TCGA-AC-A23H	BRCA	TCGA	TKENM	DEG_APCC_KENBOX_2	398:402	Mutation rewiring degron network	0.1389
p.S1331P	TCGA-AN-A046	BRCA	TCGA	VRKTPTSS	DEG_SCF_FBW7_1	1314:1321	Mutation substituting flanking lysine	0.1667
p.S1331P	DO1285	BRCA	ICGC	VRKTPTSS	DEG_SCF_FBW7_1	1314:1321	Mutation substituting flanking lysine	0.1667
p.C88Y	TCGA-BS-A0TA	UCEC	TCGA	MWVYDE	LIG_APCC_ABBA_1	82:87	Mutation rewiring degron network	0.3056
p.R1308G	TCGA-CG-5728	STAD	TCGA	VRKTPTSS	DEG_SCF_FBW7_1	1314:1321	Mutation substituting flanking lysine	0.2778
p.R1308G	DO38619	STAD	ICGC	VRKTPTSS	DEG_SCF_FBW7_1	1314:1321	Mutation substituting flanking lysine	0.2778
p.E395D	TCGA-D1-A103	UCEC	TCGA	TKENM	DEG_APCC_KENBOX_2	398:402	Mutation rewiring degron network	0.25
p.G1317C	TCGA-EE-A181	SKCM	TCGA	VRKTPTSS	DEG_SCF_FBW7_1	1314:1321	Mutation altering degron motif	0.76
p.G1317C	DO37444	SKCM	ICGC	VRKTPTSS	DEG_SCF_FBW7_1	1314:1321	Mutation altering degron motif	0.76
p.P1133L	TCGA-ER-A19P	SKCM	TCGA	DSGTPS	DEG_SCF_TRCP1_1	1134:1139	Mutation blocking phosphorylation signal	0.75
p.P1133L	DO47623	SKCM	ICGC	DSGTPS	DEG_SCF_TRCP1_1	1134:1139	Mutation blocking phosphorylation signal	0.75
p.A1321T	TCGA-F5-6814	READ	TCGA	VRKTPTSS	DEG_SCF_FBW7_1	1314:1321	Mutation altering degron motif	0.7139
p.A1321T	DO36556	READ	ICGC	VRKTPTSS	DEG_SCF_FBW7_1	1314:1321	Mutation altering degron motif	0.7139
p.P1329L	TCGA-FI-A2D0	UCEC	TCGA	VRKTPTSS	DEG_SCF_FBW7_1	1314:1321	Mutation rewiring degron network	0.1111
p.P1329L	DO43891	UCEC	ICGC	VRKTPTSS	DEG_SCF_FBW7_1	1314:1321	Mutation rewiring degron network	0.1111
p.P1313H	TCGA-GN-A26C	SKCM	TCGA	VRKTPTSS	DEG_SCF_FBW7_1	1314:1321	Mutation rewiring degron network	0.3056
p.P1313H	DO37782	SKCM	ICGC	VRKTPTSS	DEG_SCF_FBW7_1	1314:1321	Mutation rewiring degron network	0.3056
p.M86V	TCGA-QQ-A5VC	SARC	TCGA	MWVYDE	LIG_APCC_ABBA_1	82:87	Mutation altering degron motif	0.7208
p.D1137Y	TCGA-VQ-A8P2	STAD	TCGA	DSGTPS	DEG_SCF_TRCP1_1	1134:1139	Mutation altering degron motif	0.7325
p.D1137Y	DO51761	STAD	ICGC	DSGTPS	DEG_SCF_TRCP1_1	1134:1139	Mutation altering degron motif	0.7325
p.S396F	DO2401	BRCA	ICGC	TKENM	DEG_APCC_KENBOX_2	398:402	Mutation rewiring degron network	0.2778
p.L388F	DO230342	COCA	ICGC	TKENM	DEG_APCC_KENBOX_2	398:402	Mutation rewiring degron network	0.0556
p.V1324G	DO228934	LICA	ICGC	VRKTPTSS	DEG_SCF_FBW7_1	1314:1321	Mutation rewiring degron network	0.25
p.P1313L	DO228957	LICA	ICGC	VRKTPTSS	DEG_SCF_FBW7_1	1314:1321	Mutation rewiring degron network	0.3056
p.P1329T	DO229032	LICA	ICGC	VRKTPTSS	DEG_SCF_FBW7_1	1314:1321	Mutation rewiring degron network	0.1111
p.T403A	DO50908	LICA	ICGC	TKENM	DEG_APCC_KENBOX_2	398:402	Mutation rewiring degron network	0.3056
p.E76Q	DO52202	LIHC	ICGC	MWVYDE	LIG_APCC_ABBA_1	82:87	Mutation rewiring degron network	0.1667
p.Y85C	DO23134	LINC	ICGC	MWVYDE	LIG_APCC_ABBA_1	82:87	Mutation altering degron motif	0.8198
p.T1307A	DO50785	LIRI	ICGC	VRKTPTSS	DEG_SCF_FBW7_1	1314:1321	Mutation substituting flanking lysine	0.25
p.P1432S	DO220885	MELA	ICGC	DKDEYTFSP	CBL_PTK	1417:1425	Mutation rewiring degron network	0.1389
p.S1316F	DO222595	MELA	ICGC	VRKTPTSS	DEG_SCF_FBW7_1	1314:1321	Mutation altering degron motif	0.7982
p.P1412S	DO222859	MELA	ICGC	DKDEYTFSP	CBL_PTK	1417:1425	Mutation rewiring degron network	0.1944
p.M91V	DO220250	SARC	ICGC	MWVYDE	LIG_APCC_ABBA_1	82:87	Mutation rewiring degron network	0.2222
p.E400D	DO42312	UCEC	ICGC	TKENM	DEG_APCC_KENBOX_2	398:402	Mutation altering degron motif	0.6758
p.C93Y	DO43298	UCEC	ICGC	MWVYDE	LIG_APCC_ABBA_1	82:87	Mutation rewiring degron network	0.1667
p.T1319A	SIDM00967	Ovarian Carcinoma	GDSC	VRKTPTSS	DEG_SCF_FBW7_1	1314:1321	Mutation altering degron motif	0.6028
p.T1319A	SIDM00969	Ovarian Carcinoma	GDSC	VRKTPTSS	DEG_SCF_FBW7_1	1314:1321	Mutation altering degron motif	0.6028
p.T1319A	SIDM01122	Non-Small Cell Lung Carcinoma	GDSC	VRKTPTSS	DEG_SCF_FBW7_1	1314:1321	Mutation altering degron motif	0.6028
p.T1319A	SIDM01099	Neuroblastoma	GDSC	VRKTPTSS	DEG_SCF_FBW7_1	1314:1321	Mutation altering degron motif	0.6028
p.T1319A	SIDM00751	Non-Small Cell Lung Carcinoma	GDSC	VRKTPTSS	DEG_SCF_FBW7_1	1314:1321	Mutation altering degron motif	0.6028
p.T1319A	SIDM00650	Small Cell Lung Carcinoma	GDSC	VRKTPTSS	DEG_SCF_FBW7_1	1314:1321	Mutation altering degron motif	0.6028
p.T1319A	SIDM00203	Ewing's Sarcoma	GDSC	VRKTPTSS	DEG_SCF_FBW7_1	1314:1321	Mutation altering degron motif	0.6028
p.T1319A	SIDM00878	Breast Carcinoma	GDSC	VRKTPTSS	DEG_SCF_FBW7_1	1314:1321	Mutation altering degron motif	0.6028
p.T1319A	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	VRKTPTSS	DEG_SCF_FBW7_1	1314:1321	Mutation altering degron motif	0.6028
p.T1319A	SIDM00793	Burkitt's Lymphoma	GDSC	VRKTPTSS	DEG_SCF_FBW7_1	1314:1321	Mutation altering degron motif	0.6028
p.T1319A	SIDM01133	Other Solid Cancers	GDSC	VRKTPTSS	DEG_SCF_FBW7_1	1314:1321	Mutation altering degron motif	0.6028
p.T1319A	SIDM01681	Non-Cancerous	GDSC	VRKTPTSS	DEG_SCF_FBW7_1	1314:1321	Mutation altering degron motif	0.6028
p.T1319A	SIDM00721	Small Cell Lung Carcinoma	GDSC	VRKTPTSS	DEG_SCF_FBW7_1	1314:1321	Mutation altering degron motif	0.6028
p.T1319A	SIDM00808	Burkitt's Lymphoma	GDSC	VRKTPTSS	DEG_SCF_FBW7_1	1314:1321	Mutation altering degron motif	0.6028
p.T1319A	SIDM01318	Hepatocellular Carcinoma	GDSC	VRKTPTSS	DEG_SCF_FBW7_1	1314:1321	Mutation altering degron motif	0.6028
p.T1319A	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	VRKTPTSS	DEG_SCF_FBW7_1	1314:1321	Mutation altering degron motif	0.6028
p.T1319A	SIDM01677	Non-Small Cell Lung Carcinoma	GDSC	VRKTPTSS	DEG_SCF_FBW7_1	1314:1321	Mutation altering degron motif	0.6028
p.T1319A	SIDM01387	Small Cell Lung Carcinoma	GDSC	VRKTPTSS	DEG_SCF_FBW7_1	1314:1321	Mutation altering degron motif	0.6028
p.T1319A	SIDM01254	Burkitt's Lymphoma	GDSC	VRKTPTSS	DEG_SCF_FBW7_1	1314:1321	Mutation altering degron motif	0.6028
p.K399M	SIDM00250	Esophageal Squamous Cell Carcinoma	GDSC	TKENM	DEG_APCC_KENBOX_2	398:402	Mutation altering degron motif	0.8062
p.K399M	TE-4	oesophagus	COSMIC	TKENM	DEG_APCC_KENBOX_2	398:402	Mutation altering degron motif	0.8062
p.K394M	ACH-000917	Esophageal Cancer	CCLE	TKENM	DEG_APCC_KENBOX_2	398:402	Mutation rewiring degron network	0.2222
p.K394M	TE-4	oesophagus	COSMIC	TKENM	DEG_APCC_KENBOX_2	398:402	Mutation rewiring degron network	0.2222
p.R1327Q	ACH-000999	Colon/Colorectal Cancer	CCLE	VRKTPTSS	DEG_SCF_FBW7_1	1314:1321	Mutation substituting flanking lysine	0.2778
p.R1327Q	SNU-1040	large intestine	COSMIC	VRKTPTSS	DEG_SCF_FBW7_1	1314:1321	Mutation substituting flanking lysine	0.2778
p.D1412N	ACH-001416	Bladder Cancer	CCLE	DKDEYTFSP	CBL_PTK	1417:1425	Mutation rewiring degron network	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TOP2B

UniProt ID: Q02880

Entrez ID: 7155

Protein name: DNA topoisomerase 2-beta (EC 5.6.2.2) (DNA topoisomerase II, beta isozyme)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TOP2B in