DegronMD - Q02880(TOP2B)

FUNCTION: Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand. {ECO:0000269|PubMed:10684600}.

GO - Biological processes (BP): axonogenesis [GO:0007409]; DNA topological change [GO:0006265]; forebrain development [GO:0030900]; neuron migration [GO:0001764]; positive regulation of single stranded viral RNA replication via double stranded DNA intermediate [GO:0045870]; resolution of meiotic recombination intermediates [GO:000... View more >>

GO - Molecular function (MF): ATP binding [GO:0005524]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity [GO:0003918]; enzyme binding [GO:0019899]; histone deacetylase binding [GO:0042826]; metal ion binding [GO:0046872]; protein C-terminus binding ... View more >>

GO - Cellular component (CC): cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]

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Degron hit	Class	E3 ligase	Source protein	Location	Detail
DKDEYTFSP	CBL_PTK	CBL	DNA topoisomerase 2-beta	1417:1425	More..
TKENM	DEG_APCC_KENBOX_2	APC,CDC20,FZR1	DNA topoisomerase 2-beta	398:402	More..
VRKTPTSS	DEG_SCF_FBW7_1	FBXW7	DNA topoisomerase 2-beta	1314:1321	More..
DSGTPS	DEG_SCF_TRCP1_1	BTRC	DNA topoisomerase 2-beta	1134:1139	More..
MWVYDE	LIG_APCC_ABBA_1	APC,CDC20,FZR1	DNA topoisomerase 2-beta	82:87	More..

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Y85C	DO23134	LINC	ICGC	MWVYDE	LIG_APCC_ABBA_1	82:87	Mutation altering degron motif	0.8198
p.K399M	SIDM00250	Esophageal Squamous Cell Carcinoma	GDSC	TKENM	DEG_APCC_KENBOX_2	398:402	Mutation altering degron motif	0.8062
p.K399M	TE-4	oesophagus	COSMIC	TKENM	DEG_APCC_KENBOX_2	398:402	Mutation altering degron motif	0.8062
p.S1316F	DO222595	MELA	ICGC	VRKTPTSS	DEG_SCF_FBW7_1	1314:1321	Mutation altering degron motif	0.7982
p.G1317C	TCGA-EE-A181	SKCM	TCGA	VRKTPTSS	DEG_SCF_FBW7_1	1314:1321	Mutation altering degron motif	0.76
p.G1317C	DO37444	SKCM	ICGC	VRKTPTSS	DEG_SCF_FBW7_1	1314:1321	Mutation altering degron motif	0.76
p.P1133L	TCGA-ER-A19P	SKCM	TCGA	DSGTPS	DEG_SCF_TRCP1_1	1134:1139	Mutation blocking phosphorylation signal	0.75
p.P1133L	DO47623	SKCM	ICGC	DSGTPS	DEG_SCF_TRCP1_1	1134:1139	Mutation blocking phosphorylation signal	0.75
p.D1137Y	TCGA-VQ-A8P2	STAD	TCGA	DSGTPS	DEG_SCF_TRCP1_1	1134:1139	Mutation altering degron motif	0.7325
p.D1137Y	DO51761	STAD	ICGC	DSGTPS	DEG_SCF_TRCP1_1	1134:1139	Mutation altering degron motif	0.7325
p.M86V	TCGA-QQ-A5VC	SARC	TCGA	MWVYDE	LIG_APCC_ABBA_1	82:87	Mutation altering degron motif	0.7208
p.A1321T	TCGA-F5-6814	READ	TCGA	VRKTPTSS	DEG_SCF_FBW7_1	1314:1321	Mutation altering degron motif	0.7139
p.A1321T	DO36556	READ	ICGC	VRKTPTSS	DEG_SCF_FBW7_1	1314:1321	Mutation altering degron motif	0.7139
p.E400D	DO42312	UCEC	ICGC	TKENM	DEG_APCC_KENBOX_2	398:402	Mutation altering degron motif	0.6758
p.T1319A	SIDM00967	Ovarian Carcinoma	GDSC	VRKTPTSS	DEG_SCF_FBW7_1	1314:1321	Mutation altering degron motif	0.6028
p.T1319A	SIDM00969	Ovarian Carcinoma	GDSC	VRKTPTSS	DEG_SCF_FBW7_1	1314:1321	Mutation altering degron motif	0.6028
p.T1319A	SIDM01122	Non-Small Cell Lung Carcinoma	GDSC	VRKTPTSS	DEG_SCF_FBW7_1	1314:1321	Mutation altering degron motif	0.6028
p.T1319A	SIDM01099	Neuroblastoma	GDSC	VRKTPTSS	DEG_SCF_FBW7_1	1314:1321	Mutation altering degron motif	0.6028
p.T1319A	SIDM00751	Non-Small Cell Lung Carcinoma	GDSC	VRKTPTSS	DEG_SCF_FBW7_1	1314:1321	Mutation altering degron motif	0.6028
p.T1319A	SIDM00650	Small Cell Lung Carcinoma	GDSC	VRKTPTSS	DEG_SCF_FBW7_1	1314:1321	Mutation altering degron motif	0.6028

Showing 1 to 20 of 61 entries

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No resistance data available for this Degron.

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

TOP2B

UniProt ID: Q02880

Entrez ID: 7155

Protein name: DNA topoisomerase 2-beta (EC 5.6.2.2) (DNA topoisomerase II, beta isozyme)

External links: UniprotKB HGNC RefSeq COSMIC

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No resistance data available for this Degron.

Kaplan plot for TOP2B in