DegronMD

Uniprot ID: Q02880

Source protein: DNA topoisomerase 2-beta

Source gene: TOP2B

Class: LIG_APCC_ABBA_1

Location: 82:87

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7467

ASA_SCORE: 47.9

COIL: 0.244

CONS_SCORE: 0.3376

DSS_SCORE: 0.0772

HELIX: 0.0052

FCONS_SCORE: 0.8436

RIG_SCORE: 0.9679

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.C88Y	TCGA-BS-A0TA	UCEC	TCGA	MWVYDE	LIG_APCC_ABBA_1	0.3056
p.M86V	TCGA-QQ-A5VC	SARC	TCGA	MWVYDE	LIG_APCC_ABBA_1	0.7208
p.E76Q	DO52202	LIHC	ICGC	MWVYDE	LIG_APCC_ABBA_1	0.1667
p.Y85C	DO23134	LINC	ICGC	MWVYDE	LIG_APCC_ABBA_1	0.8198
p.M91V	DO220250	SARC	ICGC	MWVYDE	LIG_APCC_ABBA_1	0.2222
p.C93Y	DO43298	UCEC	ICGC	MWVYDE	LIG_APCC_ABBA_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q02880	DNA topoisomerase 2-beta	LIG_APCC_ABBA_1	82:87	MWVYDE	APC,CDC20,FZR1	0.7467	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons