DegronMD: protein-targeted degradation, mutation and drug response to degrons
Home
(current)
Browse
Proteins/Degrons
Mutations
Drug response
Network-rewiring
Drug resistance
Search
Tutorial
Download
Contact
Links
BSML
CPH
CGC
Degron:
DKDEYTFSP
Uniprot ID:
Q02880
Source protein:
DNA topoisomerase 2-beta
Source gene:
TOP2B
Class:
CBL_PTK
Location:
1417:1425
E3 ligase:
CBL
DEGRON score:
0.9484
ASA_SCORE:
88.7556
COIL:
0.7932
CONS_SCORE:
0.2168
DSS_SCORE:
0.5941
HELIX:
0.1718
FCONS_SCORE:
0.9677
RIG_SCORE:
0.7058
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.P1432S
DO220885
MELA
ICGC
DKDEYTFSP
CBL_PTK
0.1389
p.P1412S
DO222859
MELA
ICGC
DKDEYTFSP
CBL_PTK
0.1944
p.D1412N
ACH-001416
Bladder Cancer
CCLE
DKDEYTFSP
CBL_PTK
0.1944
Drug responses associated with TOP2B mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DKDEYTFSP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q02880
DNA topoisomerase 2-beta
CBL_PTK
1417:1425
DKDEYTFSP
CBL
0.9484
More...
