DegronMD

Uniprot ID: Q02880

Source protein: DNA topoisomerase 2-beta

Source gene: TOP2B

Class: DEG_APCC_KENBOX_2

Location: 398:402

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7296

ASA_SCORE: 75.86

COIL: 0.6124

CONS_SCORE: 0.6825

DSS_SCORE: 0.4298

HELIX: 0.218

FCONS_SCORE: 1.2768

RIG_SCORE: 0.7911

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S391F	TCGA-AC-A23H	BRCA	TCGA	TKENM	DEG_APCC_KENBOX_2	0.1389
p.E395D	TCGA-D1-A103	UCEC	TCGA	TKENM	DEG_APCC_KENBOX_2	0.25
p.S396F	DO2401	BRCA	ICGC	TKENM	DEG_APCC_KENBOX_2	0.2778
p.L388F	DO230342	COCA	ICGC	TKENM	DEG_APCC_KENBOX_2	0.0556
p.T403A	DO50908	LICA	ICGC	TKENM	DEG_APCC_KENBOX_2	0.3056
p.E400D	DO42312	UCEC	ICGC	TKENM	DEG_APCC_KENBOX_2	0.6758
p.K399M	SIDM00250	Esophageal Squamous Cell Carcinoma	GDSC	TKENM	DEG_APCC_KENBOX_2	0.8062
p.K399M	TE-4	oesophagus	COSMIC	TKENM	DEG_APCC_KENBOX_2	0.8062
p.K394M	ACH-000917	Esophageal Cancer	CCLE	TKENM	DEG_APCC_KENBOX_2	0.2222
p.K394M	TE-4	oesophagus	COSMIC	TKENM	DEG_APCC_KENBOX_2	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons