DegronMD

Uniprot ID: Q02880

Source protein: DNA topoisomerase 2-beta

Source gene: TOP2B

Class: DEG_SCF_FBW7_1

Location: 1314:1321

E3 ligase: FBXW7

DEGRON score: 0.9483

ASA_SCORE: 105.375

COIL: 0.927

CONS_SCORE: 0.2141

DSS_SCORE: 0.7551

HELIX: 0.0209

FCONS_SCORE: 0.9369

RIG_SCORE: 0.5972

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1331P	TCGA-AN-A046	BRCA	TCGA	VRKTPTSS	DEG_SCF_FBW7_1	0.1667
p.S1331P	DO1285	BRCA	ICGC	VRKTPTSS	DEG_SCF_FBW7_1	0.1667
p.R1308G	TCGA-CG-5728	STAD	TCGA	VRKTPTSS	DEG_SCF_FBW7_1	0.2778
p.R1308G	DO38619	STAD	ICGC	VRKTPTSS	DEG_SCF_FBW7_1	0.2778
p.G1317C	TCGA-EE-A181	SKCM	TCGA	VRKTPTSS	DEG_SCF_FBW7_1	0.76
p.G1317C	DO37444	SKCM	ICGC	VRKTPTSS	DEG_SCF_FBW7_1	0.76
p.A1321T	TCGA-F5-6814	READ	TCGA	VRKTPTSS	DEG_SCF_FBW7_1	0.7139
p.A1321T	DO36556	READ	ICGC	VRKTPTSS	DEG_SCF_FBW7_1	0.7139
p.P1329L	TCGA-FI-A2D0	UCEC	TCGA	VRKTPTSS	DEG_SCF_FBW7_1	0.1111
p.P1329L	DO43891	UCEC	ICGC	VRKTPTSS	DEG_SCF_FBW7_1	0.1111
p.P1313H	TCGA-GN-A26C	SKCM	TCGA	VRKTPTSS	DEG_SCF_FBW7_1	0.3056
p.P1313H	DO37782	SKCM	ICGC	VRKTPTSS	DEG_SCF_FBW7_1	0.3056
p.V1324G	DO228934	LICA	ICGC	VRKTPTSS	DEG_SCF_FBW7_1	0.25
p.P1313L	DO228957	LICA	ICGC	VRKTPTSS	DEG_SCF_FBW7_1	0.3056
p.P1329T	DO229032	LICA	ICGC	VRKTPTSS	DEG_SCF_FBW7_1	0.1111
p.T1307A	DO50785	LIRI	ICGC	VRKTPTSS	DEG_SCF_FBW7_1	0.25
p.S1316F	DO222595	MELA	ICGC	VRKTPTSS	DEG_SCF_FBW7_1	0.7982
p.T1319A	SIDM00967	Ovarian Carcinoma	GDSC	VRKTPTSS	DEG_SCF_FBW7_1	0.6028
p.T1319A	SIDM00969	Ovarian Carcinoma	GDSC	VRKTPTSS	DEG_SCF_FBW7_1	0.6028
p.T1319A	SIDM01122	Non-Small Cell Lung Carcinoma	GDSC	VRKTPTSS	DEG_SCF_FBW7_1	0.6028
p.T1319A	SIDM01099	Neuroblastoma	GDSC	VRKTPTSS	DEG_SCF_FBW7_1	0.6028
p.T1319A	SIDM00751	Non-Small Cell Lung Carcinoma	GDSC	VRKTPTSS	DEG_SCF_FBW7_1	0.6028
p.T1319A	SIDM00650	Small Cell Lung Carcinoma	GDSC	VRKTPTSS	DEG_SCF_FBW7_1	0.6028
p.T1319A	SIDM00203	Ewing's Sarcoma	GDSC	VRKTPTSS	DEG_SCF_FBW7_1	0.6028
p.T1319A	SIDM00878	Breast Carcinoma	GDSC	VRKTPTSS	DEG_SCF_FBW7_1	0.6028
p.T1319A	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	VRKTPTSS	DEG_SCF_FBW7_1	0.6028
p.T1319A	SIDM00793	Burkitt's Lymphoma	GDSC	VRKTPTSS	DEG_SCF_FBW7_1	0.6028
p.T1319A	SIDM01133	Other Solid Cancers	GDSC	VRKTPTSS	DEG_SCF_FBW7_1	0.6028
p.T1319A	SIDM01681	Non-Cancerous	GDSC	VRKTPTSS	DEG_SCF_FBW7_1	0.6028
p.T1319A	SIDM00721	Small Cell Lung Carcinoma	GDSC	VRKTPTSS	DEG_SCF_FBW7_1	0.6028
p.T1319A	SIDM00808	Burkitt's Lymphoma	GDSC	VRKTPTSS	DEG_SCF_FBW7_1	0.6028
p.T1319A	SIDM01318	Hepatocellular Carcinoma	GDSC	VRKTPTSS	DEG_SCF_FBW7_1	0.6028
p.T1319A	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	VRKTPTSS	DEG_SCF_FBW7_1	0.6028
p.T1319A	SIDM01677	Non-Small Cell Lung Carcinoma	GDSC	VRKTPTSS	DEG_SCF_FBW7_1	0.6028
p.T1319A	SIDM01387	Small Cell Lung Carcinoma	GDSC	VRKTPTSS	DEG_SCF_FBW7_1	0.6028
p.T1319A	SIDM01254	Burkitt's Lymphoma	GDSC	VRKTPTSS	DEG_SCF_FBW7_1	0.6028
p.R1327Q	ACH-000999	Colon/Colorectal Cancer	CCLE	VRKTPTSS	DEG_SCF_FBW7_1	0.2778
p.R1327Q	SNU-1040	large_intestine	COSMIC	VRKTPTSS	DEG_SCF_FBW7_1	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VRKTPTSS

Degron related mutations and impact score

Drug responses associated with TOP2B mutations

All proteins holding degron of VRKTPTSS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q02880	DNA topoisomerase 2-beta	DEG_SCF_FBW7_1	1314:1321	VRKTPTSS	FBXW7	0.9483	More...