DegronMD

Uniprot ID: Q02880

Source protein: DNA topoisomerase 2-beta

Source gene: TOP2B

Class: DEG_SCF_TRCP1_1

Location: 1134:1139

E3 ligase: BTRC

DEGRON score: 0.9116

ASA_SCORE: 84.95

COIL: 0.9485

CONS_SCORE: 0.216

DSS_SCORE: 0.6941

HELIX: 0.0175

FCONS_SCORE: 0.7034

RIG_SCORE: 0.5115

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1133L	TCGA-ER-A19P	SKCM	TCGA	DSGTPS	DEG_SCF_TRCP1_1	0.75
p.P1133L	DO47623	SKCM	ICGC	DSGTPS	DEG_SCF_TRCP1_1	0.75
p.D1137Y	TCGA-VQ-A8P2	STAD	TCGA	DSGTPS	DEG_SCF_TRCP1_1	0.7325
p.D1137Y	DO51761	STAD	ICGC	DSGTPS	DEG_SCF_TRCP1_1	0.7325

DegronMD: protein-targeted degradation, mutation and drug response to degrons