DegronMD

Uniprot ID: Q6V0I7

Source protein: Protocadherin Fat 4

Source gene: FAT4

Class: DEG_SCF_TRCP1_1

Location: 3484:3489

E3 ligase: BTRC

DEGRON score: 0.6812

ASA_SCORE: 63.5167

COIL: 0.8017

CONS_SCORE: 0.4576

DSS_SCORE: 0.2662

HELIX: 0.0072

FCONS_SCORE: 1.0167

RIG_SCORE: 0.6891

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G3492C	TCGA-18-3411	LUSC	TCGA	DSGTPS	DEG_SCF_TRCP1_1	0.25
p.D3484Y	TCGA-91-A4BC	LUAD	TCGA	DSGTPS	DEG_SCF_TRCP1_1	0.7325
p.S3495F	TCGA-B5-A1MX	UCEC	TCGA	DSGTPS	DEG_SCF_TRCP1_1	0.1667
p.A3482D	TCGA-BR-8680	STAD	TCGA	DSGTPS	DEG_SCF_TRCP1_1	0.2778
p.S3485L	TCGA-FW-A3R5	SKCM	TCGA	DSGTPS	DEG_SCF_TRCP1_1	0.7667
p.T3491K	SIDM00338	Acute Myeloid Leukemia	GDSC	DSGTPS	DEG_SCF_TRCP1_1	0.2778
p.T3491K	ACH-000439	Leukemia	CCLE	DSGTPS	DEG_SCF_TRCP1_1	0.2778
p.T3491K	ME-1	haematopoietic_and_lymphoid_tissue	COSMIC	DSGTPS	DEG_SCF_TRCP1_1	0.2778
p.P3474L	SIDM00545	Melanoma	GDSC	DSGTPS	DEG_SCF_TRCP1_1	0.0556
p.P3474L	ACH-000987	Skin Cancer	CCLE	DSGTPS	DEG_SCF_TRCP1_1	0.0556
p.P3474L	Mewo	skin	COSMIC	DSGTPS	DEG_SCF_TRCP1_1	0.0556
p.L3481F	SIDM00230	Small Cell Lung Carcinoma	GDSC	DSGTPS	DEG_SCF_TRCP1_1	0.25
p.L3481F	ACH-002145	Lung Cancer	CCLE	DSGTPS	DEG_SCF_TRCP1_1	0.25
p.L3481F	IST-SL2	lung	COSMIC	DSGTPS	DEG_SCF_TRCP1_1	0.25
p.A3482T	SIDM01608	Endometrial Carcinoma	GDSC	DSGTPS	DEG_SCF_TRCP1_1	0.2778
p.A3482T	ACH-000990	Endometrial/Uterine Cancer	CCLE	DSGTPS	DEG_SCF_TRCP1_1	0.2778
p.V3480F	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	DSGTPS	DEG_SCF_TRCP1_1	0.2222
p.V3480F	ACH-000891	Lung Cancer	CCLE	DSGTPS	DEG_SCF_TRCP1_1	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons