DegronMD - Q96P47(AGAP3)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R864W	TCGA-28-1746	GBM	TCGA	LAPTPNRE	DEG_SCF_FBW7_2	850:857	Mutation rewiring degron network	0.1389
p.R864W	DO13564	GBM	ICGC	LAPTPNRE	DEG_SCF_FBW7_2	850:857	Mutation rewiring degron network	0.1389
p.R524H	TCGA-32-2616	GBM	TCGA	VLSSS	DEG_SPOP_SBC_1	526:530	Mutation rewiring degron network	0.2778
p.R524H	TCGA-A6-6781	COAD	TCGA	VLSSS	DEG_SPOP_SBC_1	526:530	Mutation rewiring degron network	0.2778
p.R524H	DO8447	COAD	ICGC	VLSSS	DEG_SPOP_SBC_1	526:530	Mutation rewiring degron network	0.2778
p.R524H	DO13462	GBM	ICGC	VLSSS	DEG_SPOP_SBC_1	526:530	Mutation rewiring degron network	0.2778
p.P523L	TCGA-41-2572	GBM	TCGA	VLSSS	DEG_SPOP_SBC_1	526:530	Mutation rewiring degron network	0.25
p.P523L	DO11465	GBM	ICGC	VLSSS	DEG_SPOP_SBC_1	526:530	Mutation rewiring degron network	0.25
p.R851L	TCGA-69-7980	LUAD	TCGA	LAPTPNRE	DEG_SCF_FBW7_2	850:857	Mutation altering degron motif	0.8428
p.R851L	SIDM01677	Non-Small Cell Lung Carcinoma	GDSC	LAPTPNRE	DEG_SCF_FBW7_2	850:857	Mutation altering degron motif	0.8428
p.A324V	TCGA-AJ-A3EL	UCEC	TCGA	AASST	DEG_SPOP_SBC_1	320:324	Mutation altering degron motif	0.6936
p.A324V	DO41542	UCEC	ICGC	AASST	DEG_SPOP_SBC_1	320:324	Mutation altering degron motif	0.6936
p.V311M	TCGA-AP-A059	UCEC	TCGA	VPSTPSIS	DEG_SCF_FBW7_1	303:310	Mutation rewiring degron network	0.3056
p.V311M	TCGA-AP-A059	UCEC	TCGA	AASST	DEG_SPOP_SBC_1	320:324	Mutation rewiring degron network	0.0833
p.V311M	DO41361	UCEC	ICGC	VPSTPSIS	DEG_SCF_FBW7_1	303:310	Mutation rewiring degron network	0.3056
p.V311M	DO41361	UCEC	ICGC	AASST	DEG_SPOP_SBC_1	320:324	Mutation rewiring degron network	0.0833
p.A470T	TCGA-AP-A1DK	UCEC	TCGA	PLSSS	DEG_SPOP_SBC_1	478:482	Mutation rewiring degron network	0.1111
p.A470T	DO42033	UCEC	ICGC	PLSSS	DEG_SPOP_SBC_1	478:482	Mutation rewiring degron network	0.1111
p.R863H	TCGA-AP-A1DK	UCEC	TCGA	LAPTPNRE	DEG_SCF_FBW7_2	850:857	Mutation rewiring degron network	0.1667
p.P858A	TCGA-CF-A1HR	BLCA	TCGA	LAPTPNRE	DEG_SCF_FBW7_2	850:857	Mutation rewiring degron network	0.3056
p.D334N	TCGA-EI-6882	READ	TCGA	AASST	DEG_SPOP_SBC_1	320:324	Mutation rewiring degron network	0.0556
p.D334N	DO36531	READ	ICGC	AASST	DEG_SPOP_SBC_1	320:324	Mutation rewiring degron network	0.0556
p.G527W	TCGA-ER-A19K	SKCM	TCGA	VLSSS	DEG_SPOP_SBC_1	526:530	Mutation altering degron motif	0.7825
p.G527W	DO47672	SKCM	ICGC	VLSSS	DEG_SPOP_SBC_1	526:530	Mutation altering degron motif	0.7825
p.H529Q	TCGA-KB-A6F7	STAD	TCGA	VLSSS	DEG_SPOP_SBC_1	526:530	Mutation altering degron motif	0.7582
p.H529Q	DO50129	STAD	ICGC	VLSSS	DEG_SPOP_SBC_1	526:530	Mutation altering degron motif	0.7582
p.G329V	TCGA-MI-A75I	LIHC	TCGA	AASST	DEG_SPOP_SBC_1	320:324	Mutation rewiring degron network	0.1944
p.G329V	DO49712	LIHC	ICGC	AASST	DEG_SPOP_SBC_1	320:324	Mutation rewiring degron network	0.1944
p.G297R	TCGA-VQ-A8P2	STAD	TCGA	VPSTPSIS	DEG_SCF_FBW7_1	303:310	Mutation rewiring degron network	0.1667
p.G297R	DO51761	STAD	ICGC	VPSTPSIS	DEG_SCF_FBW7_1	303:310	Mutation rewiring degron network	0.1667
p.G527E	TCGA-XF-AAN7	BLCA	TCGA	VLSSS	DEG_SPOP_SBC_1	526:530	Mutation altering degron motif	0.7199
p.G527E	DO51946	BLCA	ICGC	VLSSS	DEG_SPOP_SBC_1	526:530	Mutation altering degron motif	0.7199
p.P527A	DO469	BLCA	ICGC	VLSSS	DEG_SPOP_SBC_1	526:530	Mutation altering degron motif	0.7503
p.A324G	DO224802	BRCA	ICGC	AASST	DEG_SPOP_SBC_1	320:324	Mutation altering degron motif	0.754
p.A331T	DO228488	BRCA	ICGC	AASST	DEG_SPOP_SBC_1	320:324	Mutation rewiring degron network	0.1389
p.G489R	DO234195	ESAD	ICGC	PLSSS	DEG_SPOP_SBC_1	478:482	Mutation rewiring degron network	0.1389
p.R481C	DO234462	ESAD	ICGC	PLSSS	DEG_SPOP_SBC_1	478:482	Mutation altering degron motif	0.8301
p.A522T	DO233766	GACA	ICGC	VLSSS	DEG_SPOP_SBC_1	526:530	Mutation rewiring degron network	0.2222
p.R524C	DO233885	GACA	ICGC	VLSSS	DEG_SPOP_SBC_1	526:530	Mutation rewiring degron network	0.2778
p.V535F	DO228948	LICA	ICGC	VLSSS	DEG_SPOP_SBC_1	526:530	Mutation rewiring degron network	0.1944
p.G522V	DO228952	LICA	ICGC	VLSSS	DEG_SPOP_SBC_1	526:530	Mutation rewiring degron network	0.2222
p.G527V	DO228978	LICA	ICGC	VLSSS	DEG_SPOP_SBC_1	526:530	Mutation altering degron motif	0.7532
p.A475S	DO229022	LICA	ICGC	PLSSS	DEG_SPOP_SBC_1	478:482	Mutation rewiring degron network	0.25
p.A475S	DO42793	UCEC	ICGC	PLSSS	DEG_SPOP_SBC_1	478:482	Mutation rewiring degron network	0.25
p.G477V	DO229041	LICA	ICGC	PLSSS	DEG_SPOP_SBC_1	478:482	Mutation rewiring degron network	0.3056
p.R520L	DO23678	LUAD	ICGC	VLSSS	DEG_SPOP_SBC_1	526:530	Mutation rewiring degron network	0.1667
p.R520L	ACH-000845	Lung Cancer	CCLE	VLSSS	DEG_SPOP_SBC_1	526:530	Mutation rewiring degron network	0.1667
p.S486F	DO220886	MELA	ICGC	PLSSS	DEG_SPOP_SBC_1	478:482	Mutation rewiring degron network	0.2222
p.L294V	DO220912	MELA	ICGC	VPSTPSIS	DEG_SCF_FBW7_1	303:310	Mutation rewiring degron network	0.0833
p.S479R	DO50662	ORCA	ICGC	PLSSS	DEG_SPOP_SBC_1	478:482	Mutation altering degron motif	0.7427
p.S516R	DO50705	ORCA	ICGC	VLSSS	DEG_SPOP_SBC_1	526:530	Mutation rewiring degron network	0.0556
p.R532H	DO42033	UCEC	ICGC	VLSSS	DEG_SPOP_SBC_1	526:530	Mutation rewiring degron network	0.2778
p.T327I	DO42023	UCEC	ICGC	AASST	DEG_SPOP_SBC_1	320:324	Mutation rewiring degron network	0.25
p.A540V	DO43226	UCEC	ICGC	VLSSS	DEG_SPOP_SBC_1	526:530	Mutation rewiring degron network	0.0556
p.L473F	DO43907	UCEC	ICGC	PLSSS	DEG_SPOP_SBC_1	478:482	Mutation rewiring degron network	0.1944
p.R468W	DO43891	UCEC	ICGC	PLSSS	DEG_SPOP_SBC_1	478:482	Mutation rewiring degron network	0.0556
p.R468W	DO41361	UCEC	ICGC	PLSSS	DEG_SPOP_SBC_1	478:482	Mutation rewiring degron network	0.0556
p.R468W	ACH-002268	Brain Cancer	CCLE	PLSSS	DEG_SPOP_SBC_1	478:482	Mutation rewiring degron network	0.0556
p.R468W	LN-405	central nervous system	COSMIC	PLSSS	DEG_SPOP_SBC_1	478:482	Mutation rewiring degron network	0.0556
p.R468Q	DO43755	UCEC	ICGC	PLSSS	DEG_SPOP_SBC_1	478:482	Mutation rewiring degron network	0.0556
p.R468Q	ACH-001558	Lung Cancer	CCLE	PLSSS	DEG_SPOP_SBC_1	478:482	Mutation rewiring degron network	0.0556
p.S333N	SIDM00946	T-Lymphoblastic Leukemia	GDSC	AASST	DEG_SPOP_SBC_1	320:324	Mutation substituting flanking lysine	0.1944
p.S333N	DND-41	haematopoietic and lymphoid tissue	COSMIC	AASST	DEG_SPOP_SBC_1	320:324	Mutation substituting flanking lysine	0.1944
p.V535I	SIDM00602	Gastric Carcinoma	GDSC	VLSSS	DEG_SPOP_SBC_1	526:530	Mutation rewiring degron network	0.1944
p.V535I	ACH-000919	Gastric Cancer	CCLE	VLSSS	DEG_SPOP_SBC_1	526:530	Mutation rewiring degron network	0.1944
p.V535I	IM-95	stomach	COSMIC	VLSSS	DEG_SPOP_SBC_1	526:530	Mutation rewiring degron network	0.1944
p.G484R	SIDM00789	Colorectal Carcinoma	GDSC	PLSSS	DEG_SPOP_SBC_1	478:482	Mutation rewiring degron network	0.2778
p.G484R	SIDM01780	B-Cell Non-Hodgkin's Lymphoma	GDSC	PLSSS	DEG_SPOP_SBC_1	478:482	Mutation rewiring degron network	0.2778
p.G484R	HCT-15	large intestine	COSMIC	PLSSS	DEG_SPOP_SBC_1	478:482	Mutation rewiring degron network	0.2778
p.G522D	SIDM01032	Esophageal Squamous Cell Carcinoma	GDSC	VLSSS	DEG_SPOP_SBC_1	526:530	Mutation rewiring degron network	0.2222
p.G522D	ACH-000823	Esophageal Cancer	CCLE	VLSSS	DEG_SPOP_SBC_1	526:530	Mutation rewiring degron network	0.2222
p.G522D	KYSE-140	oesophagus	COSMIC	VLSSS	DEG_SPOP_SBC_1	526:530	Mutation rewiring degron network	0.2222
p.A860T	SIDM00327	Hodgkin's Lymphoma	GDSC	LAPTPNRE	DEG_SCF_FBW7_2	850:857	Mutation rewiring degron network	0.25
p.A860T	L-428	haematopoietic and lymphoid tissue	COSMIC	LAPTPNRE	DEG_SCF_FBW7_2	850:857	Mutation rewiring degron network	0.25
p.S330G	SIDM00014	Colorectal Carcinoma	GDSC	AASST	DEG_SPOP_SBC_1	320:324	Mutation substituting flanking lysine	0.2778
p.V319M	SIDM00971	Breast Carcinoma	GDSC	VPSTPSIS	DEG_SCF_FBW7_1	303:310	Mutation rewiring degron network	0.0833
p.V319M	SIDM00971	Breast Carcinoma	GDSC	AASST	DEG_SPOP_SBC_1	320:324	Mutation rewiring degron network	0.3056
p.A314T	SIDM00251	Gastric Carcinoma	GDSC	VPSTPSIS	DEG_SCF_FBW7_1	303:310	Mutation rewiring degron network	0.2222
p.A314T	SIDM00251	Gastric Carcinoma	GDSC	AASST	DEG_SPOP_SBC_1	320:324	Mutation rewiring degron network	0.1667
p.A314T	SIDM00161	Biliary Tract Carcinoma	GDSC	VPSTPSIS	DEG_SCF_FBW7_1	303:310	Mutation rewiring degron network	0.2222
p.A314T	SIDM00161	Biliary Tract Carcinoma	GDSC	AASST	DEG_SPOP_SBC_1	320:324	Mutation rewiring degron network	0.1667
p.A314T	TGBC11TKB	stomach	COSMIC	VPSTPSIS	DEG_SCF_FBW7_1	303:310	Mutation rewiring degron network	0.2222
p.A314T	TGBC11TKB	stomach	COSMIC	AASST	DEG_SPOP_SBC_1	320:324	Mutation rewiring degron network	0.1667
p.R489Q	SIDM01158	Squamous Cell Lung Carcinoma	GDSC	PLSSS	DEG_SPOP_SBC_1	478:482	Mutation rewiring degron network	0.1389
p.V311L	SIDM00017	Squamous Cell Lung Carcinoma	GDSC	VPSTPSIS	DEG_SCF_FBW7_1	303:310	Mutation rewiring degron network	0.3056
p.V311L	SIDM00017	Squamous Cell Lung Carcinoma	GDSC	AASST	DEG_SPOP_SBC_1	320:324	Mutation rewiring degron network	0.0833
p.A529T	ACH-000754	Lymphoma	CCLE	VLSSS	DEG_SPOP_SBC_1	526:530	Mutation altering degron motif	0.7139
p.A529T	L-428	haematopoietic and lymphoid tissue	COSMIC	VLSSS	DEG_SPOP_SBC_1	526:530	Mutation altering degron motif	0.7139
p.G487W	ACH-000832	Head and Neck Cancer	CCLE	PLSSS	DEG_SPOP_SBC_1	478:482	Mutation rewiring degron network	0.1944
p.G487W	CAL-27	upper aerodigestive tract	COSMIC	PLSSS	DEG_SPOP_SBC_1	478:482	Mutation rewiring degron network	0.1944
p.A295V	ACH-000990	Endometrial/Uterine Cancer	CCLE	VPSTPSIS	DEG_SCF_FBW7_1	303:310	Mutation rewiring degron network	0.1111
p.Y486H	ACH-002026	Endometrial/Uterine Cancer	CCLE	PLSSS	DEG_SPOP_SBC_1	478:482	Mutation rewiring degron network	0.2222
p.S478F	ACH-002190	Kidney Cancer	CCLE	PLSSS	DEG_SPOP_SBC_1	478:482	Mutation altering degron motif	0.7982
p.S478F	RCC-JF	kidney	COSMIC	PLSSS	DEG_SPOP_SBC_1	478:482	Mutation altering degron motif	0.7982
p.S530I	SNU-1040	large intestine	COSMIC	VLSSS	DEG_SPOP_SBC_1	526:530	Mutation altering degron motif	0.7341
p.S297N	DND-41	haematopoietic and lymphoid tissue	COSMIC	VPSTPSIS	DEG_SCF_FBW7_1	303:310	Mutation rewiring degron network	0.1667
p.D534E	Daudi	haematopoietic and lymphoid tissue	COSMIC	VLSSS	DEG_SPOP_SBC_1	526:530	Mutation rewiring degron network	0.2222
p.D534E	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	VLSSS	DEG_SPOP_SBC_1	526:530	Mutation rewiring degron network	0.2222
p.A322V	TOV-21G	ovary	COSMIC	AASST	DEG_SPOP_SBC_1	320:324	Mutation altering degron motif	0.6936
p.R531C	KM-H2	haematopoietic and lymphoid tissue	COSMIC	VLSSS	DEG_SPOP_SBC_1	526:530	Mutation rewiring degron network	0.3056
p.G486D	KYSE-140	oesophagus	COSMIC	PLSSS	DEG_SPOP_SBC_1	478:482	Mutation rewiring degron network	0.2222
p.P306S	NCI-H2172	lung	COSMIC	VPSTPSIS	DEG_SCF_FBW7_1	303:310	Mutation altering degron motif	0.6752
p.K330M	L-428	haematopoietic and lymphoid tissue	COSMIC	AASST	DEG_SPOP_SBC_1	320:324	Mutation substituting flanking lysine	0.2778
p.R303H	RL95-2	endometrium	COSMIC	VPSTPSIS	DEG_SCF_FBW7_1	303:310	Mutation altering degron motif	0.8244
p.R315C	KM-H2	haematopoietic and lymphoid tissue	COSMIC	VPSTPSIS	DEG_SCF_FBW7_1	303:310	Mutation rewiring degron network	0.1944
p.R315C	KM-H2	haematopoietic and lymphoid tissue	COSMIC	AASST	DEG_SPOP_SBC_1	320:324	Mutation rewiring degron network	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

AGAP3

UniProt ID: Q96P47

Entrez ID: 116988

Protein name: Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 (AGAP-3) (CRAM-associated GTPase) (CRAG) (Centaurin-gamma-3) (Cnt-g3) (MR1-interacting protein) (MRIP-1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for AGAP3 in