DegronMD

Uniprot ID: Q96P47

Source protein: Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3

Source gene: AGAP3

Class: DEG_SCF_FBW7_2

Location: 850:857

E3 ligase: FBXW7

DEGRON score: 0.9596

ASA_SCORE: 82.2

COIL: 0.9416

CONS_SCORE: 0.2865

DSS_SCORE: 0.569

HELIX: 0.0178

FCONS_SCORE: 0.995

RIG_SCORE: 0.6305

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R864W	TCGA-28-1746	GBM	TCGA	LAPTPNRE	DEG_SCF_FBW7_2	0.1389
p.R864W	DO13564	GBM	ICGC	LAPTPNRE	DEG_SCF_FBW7_2	0.1389
p.R851L	TCGA-69-7980	LUAD	TCGA	LAPTPNRE	DEG_SCF_FBW7_2	0.8428
p.R851L	SIDM01677	Non-Small Cell Lung Carcinoma	GDSC	LAPTPNRE	DEG_SCF_FBW7_2	0.8428
p.R863H	TCGA-AP-A1DK	UCEC	TCGA	LAPTPNRE	DEG_SCF_FBW7_2	0.1667
p.P858A	TCGA-CF-A1HR	BLCA	TCGA	LAPTPNRE	DEG_SCF_FBW7_2	0.3056
p.A860T	SIDM00327	Hodgkin's Lymphoma	GDSC	LAPTPNRE	DEG_SCF_FBW7_2	0.25
p.A860T	L-428	haematopoietic_and_lymphoid_tissue	COSMIC	LAPTPNRE	DEG_SCF_FBW7_2	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96P47	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3	DEG_SCF_FBW7_2	850:857	LAPTPNRE	FBXW7	0.9596	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons