DegronMD

Uniprot ID: Q96P47

Source protein: Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3

Source gene: AGAP3

Class: DEG_SPOP_SBC_1

Location: 320:324

E3 ligase: SPOP

DEGRON score: 0.9988

ASA_SCORE: 76.08

COIL: 0.9126

CONS_SCORE: 0.5762

DSS_SCORE: 0.5843

HELIX: 0.0604

FCONS_SCORE: 1.2801

RIG_SCORE: 0.6773

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A324V	TCGA-AJ-A3EL	UCEC	TCGA	AASST	DEG_SPOP_SBC_1	0.6936
p.A324V	DO41542	UCEC	ICGC	AASST	DEG_SPOP_SBC_1	0.6936
p.V311M	TCGA-AP-A059	UCEC	TCGA	AASST	DEG_SPOP_SBC_1	0.0833
p.V311M	DO41361	UCEC	ICGC	AASST	DEG_SPOP_SBC_1	0.0833
p.D334N	TCGA-EI-6882	READ	TCGA	AASST	DEG_SPOP_SBC_1	0.0556
p.D334N	DO36531	READ	ICGC	AASST	DEG_SPOP_SBC_1	0.0556
p.G329V	TCGA-MI-A75I	LIHC	TCGA	AASST	DEG_SPOP_SBC_1	0.1944
p.G329V	DO49712	LIHC	ICGC	AASST	DEG_SPOP_SBC_1	0.1944
p.A324G	DO224802	BRCA	ICGC	AASST	DEG_SPOP_SBC_1	0.754
p.A331T	DO228488	BRCA	ICGC	AASST	DEG_SPOP_SBC_1	0.1389
p.T327I	DO42023	UCEC	ICGC	AASST	DEG_SPOP_SBC_1	0.25
p.S333N	SIDM00946	T-Lymphoblastic Leukemia	GDSC	AASST	DEG_SPOP_SBC_1	0.1944
p.S333N	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	AASST	DEG_SPOP_SBC_1	0.1944
p.S330G	SIDM00014	Colorectal Carcinoma	GDSC	AASST	DEG_SPOP_SBC_1	0.2778
p.V319M	SIDM00971	Breast Carcinoma	GDSC	AASST	DEG_SPOP_SBC_1	0.3056
p.A314T	SIDM00251	Gastric Carcinoma	GDSC	AASST	DEG_SPOP_SBC_1	0.1667
p.A314T	SIDM00161	Biliary Tract Carcinoma	GDSC	AASST	DEG_SPOP_SBC_1	0.1667
p.A314T	TGBC11TKB	stomach	COSMIC	AASST	DEG_SPOP_SBC_1	0.1667
p.V311L	SIDM00017	Squamous Cell Lung Carcinoma	GDSC	AASST	DEG_SPOP_SBC_1	0.0833
p.A322V	TOV-21G	ovary	COSMIC	AASST	DEG_SPOP_SBC_1	0.6936
p.K330M	L-428	haematopoietic_and_lymphoid_tissue	COSMIC	AASST	DEG_SPOP_SBC_1	0.2778
p.R315C	KM-H2	haematopoietic_and_lymphoid_tissue	COSMIC	AASST	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A2VDJ0	Transmembrane protein 131-like	DEG_SPOP_SBC_1	993:997	AASST	SPOP	0.9931	More...
P12036	Neurofilament heavy polypeptide	DEG_SPOP_SBC_1	70:74	AASST	SPOP	0.9827	More...
P15976	Erythroid transcription factor	DEG_SPOP_SBC_1	44:48	AASST	SPOP	0.6198	More...
P29966	Myristoylated alanine-rich C-kinase substrate	DEG_SPOP_SBC_1	129:133	AASST	SPOP	0.9228	More...
P35658	Nuclear pore complex protein Nup214	DEG_SPOP_SBC_1	1554:1558	AASST	SPOP	0.9763	More...
P35658	Nuclear pore complex protein Nup214	DEG_SPOP_SBC_1	1774:1778	AASST	SPOP	0.9839	More...
Q00587	Cdc42 effector protein 1	DEG_SPOP_SBC_1	277:281	AASST	SPOP	0.9931	More...
Q02078	Myocyte-specific enhancer factor 2A	DEG_SPOP_SBC_1	169:173	AASST	SPOP	0.6185	More...
Q07687	Homeobox protein DLX-2	DEG_SPOP_SBC_1	18:22	AASST	SPOP	0.9974	More...
Q13516	Oligodendrocyte transcription factor 2	DEG_SPOP_SBC_1	90:94	AASST	SPOP	0.9738	More...
Q15554	Telomeric repeat-binding factor 2	DEG_SPOP_SBC_1	291:295	AASST	SPOP	0.9947	More...
Q15714	TSC22 domain family protein 1	DEG_SPOP_SBC_1	70:74	AASST	SPOP	0.9918	More...
Q15814	Tubulin-specific chaperone C	DEG_SPOP_SBC_1	146:150	AASST	SPOP	0.5577	More...
Q86TM6	E3 ubiquitin-protein ligase synoviolin	DEG_SPOP_SBC_1	553:557	AASST	SPOP	0.9772	More...
Q8IU81	Interferon regulatory factor 2-binding protein 1	DEG_SPOP_SBC_1	455:459	AASST	SPOP	0.8522	More...
Q8NDV7	Trinucleotide repeat-containing gene 6A protein	DEG_SPOP_SBC_1	1097:1101	AASST	SPOP	0.9707	More...
Q96F05	Uncharacterized protein C11orf24	DEG_SPOP_SBC_1	136:140	AASST	SPOP	0.9889	More...
Q96F05	Uncharacterized protein C11orf24	DEG_SPOP_SBC_1	156:160	AASST	SPOP	0.9963	More...
Q96KP1	Exocyst complex component 2	DEG_SPOP_SBC_1	916:920	AASST	SPOP	0.9073	More...
Q96P47	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3	DEG_SPOP_SBC_1	320:324	AASST	SPOP	0.9988	More...
Q9BTC0	Death-inducer obliterator 1	DEG_SPOP_SBC_1	1299:1303	AASST	SPOP	0.9885	More...
Q9BXT5	Testis-expressed protein 15	DEG_SPOP_SBC_1	1366:1370	AASST	SPOP	0.5082	More...
Q9BYI3	Hyccin	DEG_SPOP_SBC_1	355:359	AASST	SPOP	0.9992	More...
Q9BZZ2	Sialoadhesin	DEG_SPOP_SBC_1	564:568	AASST	SPOP	0.8123	More...
Q9C0A1	Zinc finger homeobox protein 2	DEG_SPOP_SBC_1	43:47	AASST	SPOP	0.9864	More...
Q9HAF1	Chromatin modification-related protein MEAF6	DEG_SPOP_SBC_1	155:159	AASST	SPOP	0.6503	More...
Q9NP87	DNA-directed DNA/RNA polymerase mu	DEG_SPOP_SBC_1	17:21	AASST	SPOP	0.983	More...
Q9UHV7	Mediator of RNA polymerase II transcription subunit 13	DEG_SPOP_SBC_1	1509:1513	AASST	SPOP	0.6304	More...
Q9UIF8	Bromodomain adjacent to zinc finger domain protein 2B	DEG_SPOP_SBC_1	11:15	AASST	SPOP	0.92	More...
Q9UIF8	Bromodomain adjacent to zinc finger domain protein 2B	DEG_SPOP_SBC_1	525:529	AASST	SPOP	0.9018	More...
Q9Y4A8	Nuclear factor erythroid 2-related factor 3	DEG_SPOP_SBC_1	132:136	AASST	SPOP	0.7076	More...
Q9Y2G4	Ankyrin repeat domain-containing protein 6	DEG_SPOP_SBC_1	637:641	AASST	SPOP	0.7804	More...
Q9Y2W3	Proton-associated sugar transporter A	DEG_SPOP_SBC_1	38:42	AASST	SPOP	0.9955	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: AASST

Degron related mutations and impact score

Drug responses associated with AGAP3 mutations

All proteins holding degron of AASST