DegronMD - Q15714(TSC22D1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.F897L	TCGA-AA-3510	COAD	TCGA	PLSST	DEG_SPOP_SBC_1	891:895	Mutation rewiring degron network	0.2778
p.F897L	TCGA-EO-A22X	UCEC	TCGA	PLSST	DEG_SPOP_SBC_1	891:895	Mutation rewiring degron network	0.2778
p.F897L	DO7783	COAD	ICGC	PLSST	DEG_SPOP_SBC_1	891:895	Mutation rewiring degron network	0.2778
p.F897L	DO43907	UCEC	ICGC	PLSST	DEG_SPOP_SBC_1	891:895	Mutation rewiring degron network	0.2778
p.R294C	TCGA-AA-3947	COAD	TCGA	APSTT	DEG_SPOP_SBC_1	295:299	Mutation rewiring degron network	0.3056
p.R294C	DO8192	COAD	ICGC	APSTT	DEG_SPOP_SBC_1	295:299	Mutation rewiring degron network	0.3056
p.R294C	SIDM00762	Non-Small Cell Lung Carcinoma	GDSC	APSTT	DEG_SPOP_SBC_1	295:299	Mutation rewiring degron network	0.3056
p.R294C	ACH-000414	Lung Cancer	CCLE	APSTT	DEG_SPOP_SBC_1	295:299	Mutation rewiring degron network	0.3056
p.R294C	NCI-H1944	lung	COSMIC	APSTT	DEG_SPOP_SBC_1	295:299	Mutation rewiring degron network	0.3056
p.N881T	TCGA-AD-5900	COAD	TCGA	PLSST	DEG_SPOP_SBC_1	891:895	Mutation rewiring degron network	0.0556
p.N881T	DO8514	COAD	ICGC	PLSST	DEG_SPOP_SBC_1	891:895	Mutation rewiring degron network	0.0556
p.V289A	TCGA-AG-A002	READ	TCGA	AVSSS	DEG_SPOP_SBC_1	279:283	Mutation rewiring degron network	0.1667
p.V289A	TCGA-AG-A002	READ	TCGA	APSTT	DEG_SPOP_SBC_1	295:299	Mutation rewiring degron network	0.1667
p.A887V	TCGA-AX-A1CE	UCEC	TCGA	PLSST	DEG_SPOP_SBC_1	891:895	Mutation rewiring degron network	0.2222
p.A887V	DO42280	UCEC	ICGC	PLSST	DEG_SPOP_SBC_1	891:895	Mutation rewiring degron network	0.2222
p.G941R	TCGA-BL-A3JM	BLCA	TCGA	DSGGMS	DEG_SCF_TRCP1_1	931:936	Mutation rewiring degron network	0.1944
p.G941R	DO532	BLCA	ICGC	DSGGMS	DEG_SCF_TRCP1_1	931:936	Mutation rewiring degron network	0.1944
p.R294H	TCGA-BR-8591	STAD	TCGA	APSTT	DEG_SPOP_SBC_1	295:299	Mutation rewiring degron network	0.3056
p.R294H	DO233272	GACA	ICGC	APSTT	DEG_SPOP_SBC_1	295:299	Mutation rewiring degron network	0.3056
p.R294H	DO47973	STAD	ICGC	APSTT	DEG_SPOP_SBC_1	295:299	Mutation rewiring degron network	0.3056
p.N305T	TCGA-E6-A1LX	UCEC	TCGA	APSTT	DEG_SPOP_SBC_1	295:299	Mutation rewiring degron network	0.1667
p.N305T	DO41020	UCEC	ICGC	APSTT	DEG_SPOP_SBC_1	295:299	Mutation rewiring degron network	0.1667
p.A70T	TCGA-VQ-A8PO	STAD	TCGA	AASST	DEG_SPOP_SBC_1	70:74	Mutation altering degron motif	0.7139
p.A70T	DO51773	STAD	ICGC	AASST	DEG_SPOP_SBC_1	70:74	Mutation altering degron motif	0.7139
p.P885S	TCGA-VQ-A924	STAD	TCGA	PLSST	DEG_SPOP_SBC_1	891:895	Mutation rewiring degron network	0.1667
p.P885S	DO51795	STAD	ICGC	PLSST	DEG_SPOP_SBC_1	891:895	Mutation rewiring degron network	0.1667
p.S281L	TCGA-VS-A94X	CESC	TCGA	AVSSS	DEG_SPOP_SBC_1	279:283	Mutation altering degron motif	0.7667
p.S281L	DO51632	CESC	ICGC	AVSSS	DEG_SPOP_SBC_1	279:283	Mutation altering degron motif	0.7667
p.N292I	DO222884	COCA	ICGC	AVSSS	DEG_SPOP_SBC_1	279:283	Mutation rewiring degron network	0.0833
p.N292I	DO222884	COCA	ICGC	APSTT	DEG_SPOP_SBC_1	295:299	Mutation rewiring degron network	0.25
p.G303D	DO11854	GBM	ICGC	APSTT	DEG_SPOP_SBC_1	295:299	Mutation rewiring degron network	0.2222
p.D269E	DO228976	LICA	ICGC	AVSSS	DEG_SPOP_SBC_1	279:283	Mutation rewiring degron network	0.0556
p.T74K	DO229018	LICA	ICGC	AASST	DEG_SPOP_SBC_1	70:74	Mutation altering degron motif	0.7306
p.A903D	DO229032	LICA	ICGC	PLSST	DEG_SPOP_SBC_1	891:895	Mutation rewiring degron network	0.1111
p.A887S	DO23510	LIRI	ICGC	PLSST	DEG_SPOP_SBC_1	891:895	Mutation rewiring degron network	0.2222
p.P286L	DO218860	SKCA	ICGC	AVSSS	DEG_SPOP_SBC_1	279:283	Mutation rewiring degron network	0.25
p.P286L	DO218860	SKCA	ICGC	APSTT	DEG_SPOP_SBC_1	295:299	Mutation rewiring degron network	0.0833
p.S282F	SIDM01156	Small Cell Lung Carcinoma	GDSC	AVSSS	DEG_SPOP_SBC_1	279:283	Mutation altering degron motif	0.7982
p.S282F	ACH-000890	Lung Cancer	CCLE	AVSSS	DEG_SPOP_SBC_1	279:283	Mutation altering degron motif	0.7982
p.S282F	SW1271	lung	COSMIC	AVSSS	DEG_SPOP_SBC_1	279:283	Mutation altering degron motif	0.7982
p.I928M	SIDM00845	Burkitt's Lymphoma	GDSC	DSGGMS	DEG_SCF_TRCP1_1	931:936	Mutation rewiring degron network	0.25
p.I928M	SIDM00461	Acute Myeloid Leukemia	GDSC	DSGGMS	DEG_SCF_TRCP1_1	931:936	Mutation rewiring degron network	0.25
p.I928M	SIDM00946	T-Lymphoblastic Leukemia	GDSC	DSGGMS	DEG_SCF_TRCP1_1	931:936	Mutation rewiring degron network	0.25
p.I928M	SIDM01519	Head and Neck Carcinoma	GDSC	DSGGMS	DEG_SCF_TRCP1_1	931:936	Mutation rewiring degron network	0.25
p.I928M	ACH-000786	Lymphoma	CCLE	DSGGMS	DEG_SCF_TRCP1_1	931:936	Mutation rewiring degron network	0.25
p.V922G	SIDM00845	Burkitt's Lymphoma	GDSC	DSGGMS	DEG_SCF_TRCP1_1	931:936	Mutation rewiring degron network	0.0833
p.T927A	SIDM01483	Melanoma	GDSC	DSGGMS	DEG_SCF_TRCP1_1	931:936	Mutation rewiring degron network	0.2222
p.T927A	ACH-000582	Skin Cancer	CCLE	DSGGMS	DEG_SCF_TRCP1_1	931:936	Mutation rewiring degron network	0.2222
p.T927A	COLO-741	large intestine	COSMIC	DSGGMS	DEG_SCF_TRCP1_1	931:936	Mutation rewiring degron network	0.2222
p.S932R	SIDM01174	Cervical Carcinoma	GDSC	DSGGMS	DEG_SCF_TRCP1_1	931:936	Mutation altering degron motif	0.7427
p.S932R	ACH-001402	Cervical Cancer	CCLE	DSGGMS	DEG_SCF_TRCP1_1	931:936	Mutation altering degron motif	0.7427
p.S932R	SW756	cervix	COSMIC	DSGGMS	DEG_SCF_TRCP1_1	931:936	Mutation altering degron motif	0.7427
p.V289G	SIDM00607	Glioblastoma	GDSC	AVSSS	DEG_SPOP_SBC_1	279:283	Mutation rewiring degron network	0.1667
p.V289G	SIDM00607	Glioblastoma	GDSC	APSTT	DEG_SPOP_SBC_1	295:299	Mutation rewiring degron network	0.1667
p.V289G	ACH-000622	Brain Cancer	CCLE	AVSSS	DEG_SPOP_SBC_1	279:283	Mutation rewiring degron network	0.1667
p.V289G	ACH-000622	Brain Cancer	CCLE	APSTT	DEG_SPOP_SBC_1	295:299	Mutation rewiring degron network	0.1667
p.V289G	KNS-42	central nervous system	COSMIC	AVSSS	DEG_SPOP_SBC_1	279:283	Mutation rewiring degron network	0.1667
p.V289G	KNS-42	central nervous system	COSMIC	APSTT	DEG_SPOP_SBC_1	295:299	Mutation rewiring degron network	0.1667
p.N883D	SIDM00818	Kidney Carcinoma	GDSC	PLSST	DEG_SPOP_SBC_1	891:895	Mutation rewiring degron network	0.1111
p.N883D	ACH-002190	Kidney Cancer	CCLE	PLSST	DEG_SPOP_SBC_1	891:895	Mutation rewiring degron network	0.1111
p.N883D	RCC-JF	kidney	COSMIC	PLSST	DEG_SPOP_SBC_1	891:895	Mutation rewiring degron network	0.1111
p.I302V	ACH-000328	Brain Cancer	CCLE	APSTT	DEG_SPOP_SBC_1	295:299	Mutation rewiring degron network	0.25
p.Y68F	ACH-001321	Thyroid Cancer	CCLE	AASST	DEG_SPOP_SBC_1	70:74	Mutation rewiring degron network	0.2778
p.Y68F	TT	thyroid	COSMIC	AASST	DEG_SPOP_SBC_1	70:74	Mutation rewiring degron network	0.2778
p.I81S	ACH-002387	Skin Cancer	CCLE	AASST	DEG_SPOP_SBC_1	70:74	Mutation rewiring degron network	0.1389
p.S60P	VA-ES-BJ	bone	COSMIC	AASST	DEG_SPOP_SBC_1	70:74	Mutation rewiring degron network	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TSC22D1

UniProt ID: Q15714

Entrez ID: 8848

Protein name: TSC22 domain family protein 1 (Cerebral protein 2) (Regulatory protein TSC-22) (TGFB-stimulated clone 22 homolog) (Transforming growth factor beta-1-induced transcript 4 protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TSC22D1 in