DegronMD

Uniprot ID: Q15714

Source protein: TSC22 domain family protein 1

Source gene: TSC22D1

Class: DEG_SCF_TRCP1_1

Location: 931:936

E3 ligase: BTRC

DEGRON score: 0.9935

ASA_SCORE: 76.95

COIL: 0.9415

CONS_SCORE: 0.3576

DSS_SCORE: 0.5218

HELIX: 0.0363

FCONS_SCORE: 1.0305

RIG_SCORE: 0.5745

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G941R	TCGA-BL-A3JM	BLCA	TCGA	DSGGMS	DEG_SCF_TRCP1_1	0.1944
p.G941R	DO532	BLCA	ICGC	DSGGMS	DEG_SCF_TRCP1_1	0.1944
p.I928M	SIDM00845	Burkitt's Lymphoma	GDSC	DSGGMS	DEG_SCF_TRCP1_1	0.25
p.I928M	SIDM00461	Acute Myeloid Leukemia	GDSC	DSGGMS	DEG_SCF_TRCP1_1	0.25
p.I928M	SIDM00946	T-Lymphoblastic Leukemia	GDSC	DSGGMS	DEG_SCF_TRCP1_1	0.25
p.I928M	SIDM01519	Head and Neck Carcinoma	GDSC	DSGGMS	DEG_SCF_TRCP1_1	0.25
p.I928M	ACH-000786	Lymphoma	CCLE	DSGGMS	DEG_SCF_TRCP1_1	0.25
p.V922G	SIDM00845	Burkitt's Lymphoma	GDSC	DSGGMS	DEG_SCF_TRCP1_1	0.0833
p.T927A	SIDM01483	Melanoma	GDSC	DSGGMS	DEG_SCF_TRCP1_1	0.2222
p.T927A	ACH-000582	Skin Cancer	CCLE	DSGGMS	DEG_SCF_TRCP1_1	0.2222
p.T927A	COLO-741	large_intestine	COSMIC	DSGGMS	DEG_SCF_TRCP1_1	0.2222
p.S932R	SIDM01174	Cervical Carcinoma	GDSC	DSGGMS	DEG_SCF_TRCP1_1	0.7427
p.S932R	ACH-001402	Cervical Cancer	CCLE	DSGGMS	DEG_SCF_TRCP1_1	0.7427
p.S932R	SW756	cervix	COSMIC	DSGGMS	DEG_SCF_TRCP1_1	0.7427

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15714	TSC22 domain family protein 1	DEG_SCF_TRCP1_1	931:936	DSGGMS	BTRC	0.9935	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons