DegronMD

Uniprot ID: Q8NDV7

Source protein: Trinucleotide repeat-containing gene 6A protein

Source gene: TNRC6A

Class: DEG_SPOP_SBC_1

Location: 1097:1101

E3 ligase: SPOP

DEGRON score: 0.9707

ASA_SCORE: 68.06

COIL: 0.828

CONS_SCORE: 0.2644

DSS_SCORE: 0.5541

HELIX: 0.143

FCONS_SCORE: 0.712

RIG_SCORE: 0.6643

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1106C	TCGA-75-6214	LUAD	TCGA	AASST	DEG_SPOP_SBC_1	0.1944
p.S1106C	DO24830	LUAD	ICGC	AASST	DEG_SPOP_SBC_1	0.1944
p.E1093D	TCGA-AA-3966	COAD	TCGA	AASST	DEG_SPOP_SBC_1	0.2222
p.E1093D	DO10068	COAD	ICGC	AASST	DEG_SPOP_SBC_1	0.2222
p.G1105D	DO234356	ESAD	ICGC	AASST	DEG_SPOP_SBC_1	0.2222
p.S1107I	DO229028	LICA	ICGC	AASST	DEG_SPOP_SBC_1	0.1667
p.G1110C	DO229037	LICA	ICGC	AASST	DEG_SPOP_SBC_1	0.0833
p.G1105V	DO229006	LICA	ICGC	AASST	DEG_SPOP_SBC_1	0.2222
p.S1107N	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	AASST	DEG_SPOP_SBC_1	0.1667
p.S1107N	ACH-000789	Lung Cancer	CCLE	AASST	DEG_SPOP_SBC_1	0.1667
p.S1107N	NCI-H810	lung	COSMIC	AASST	DEG_SPOP_SBC_1	0.1667
p.A1097V	SIDM01248	Thyroid Gland Carcinoma	GDSC	AASST	DEG_SPOP_SBC_1	0.5825
p.A1097V	SIDM01045	Endometrial Carcinoma	GDSC	AASST	DEG_SPOP_SBC_1	0.5825
p.A1097V	SIDM01167	Thyroid Gland Carcinoma	GDSC	AASST	DEG_SPOP_SBC_1	0.5825
p.A1097V	ACH-000163	Thyroid Cancer	CCLE	AASST	DEG_SPOP_SBC_1	0.5825
p.A1097V	ACH-000978	Endometrial/Uterine Cancer	CCLE	AASST	DEG_SPOP_SBC_1	0.5825
p.A1097V	ACH-001023	Thyroid Cancer	CCLE	AASST	DEG_SPOP_SBC_1	0.5825
p.A1097V	CGTH-W-1	thyroid	COSMIC	AASST	DEG_SPOP_SBC_1	0.5825
p.A1097V	EN	endometrium	COSMIC	AASST	DEG_SPOP_SBC_1	0.5825
p.P1089S	SIDM00498	Colorectal Carcinoma	GDSC	AASST	DEG_SPOP_SBC_1	0.1111
p.P1089S	ACH-000970	Colon/Colorectal Cancer	CCLE	AASST	DEG_SPOP_SBC_1	0.1111
p.P1089S	SNU-C5	large_intestine	COSMIC	AASST	DEG_SPOP_SBC_1	0.1111
p.S1107R	SIDM00618	Hepatocellular Carcinoma	GDSC	AASST	DEG_SPOP_SBC_1	0.1667
p.S1107R	ACH-000620	Liver Cancer	CCLE	AASST	DEG_SPOP_SBC_1	0.1667
p.S1107R	ACH-001610	Brain Cancer	CCLE	AASST	DEG_SPOP_SBC_1	0.1667
p.S1107R	JHH-1	liver	COSMIC	AASST	DEG_SPOP_SBC_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A2VDJ0	Transmembrane protein 131-like	DEG_SPOP_SBC_1	993:997	AASST	SPOP	0.9931	More...
P12036	Neurofilament heavy polypeptide	DEG_SPOP_SBC_1	70:74	AASST	SPOP	0.9827	More...
P15976	Erythroid transcription factor	DEG_SPOP_SBC_1	44:48	AASST	SPOP	0.6198	More...
P29966	Myristoylated alanine-rich C-kinase substrate	DEG_SPOP_SBC_1	129:133	AASST	SPOP	0.9228	More...
P35658	Nuclear pore complex protein Nup214	DEG_SPOP_SBC_1	1554:1558	AASST	SPOP	0.9763	More...
P35658	Nuclear pore complex protein Nup214	DEG_SPOP_SBC_1	1774:1778	AASST	SPOP	0.9839	More...
Q00587	Cdc42 effector protein 1	DEG_SPOP_SBC_1	277:281	AASST	SPOP	0.9931	More...
Q02078	Myocyte-specific enhancer factor 2A	DEG_SPOP_SBC_1	169:173	AASST	SPOP	0.6185	More...
Q07687	Homeobox protein DLX-2	DEG_SPOP_SBC_1	18:22	AASST	SPOP	0.9974	More...
Q13516	Oligodendrocyte transcription factor 2	DEG_SPOP_SBC_1	90:94	AASST	SPOP	0.9738	More...
Q15554	Telomeric repeat-binding factor 2	DEG_SPOP_SBC_1	291:295	AASST	SPOP	0.9947	More...
Q15714	TSC22 domain family protein 1	DEG_SPOP_SBC_1	70:74	AASST	SPOP	0.9918	More...
Q15814	Tubulin-specific chaperone C	DEG_SPOP_SBC_1	146:150	AASST	SPOP	0.5577	More...
Q86TM6	E3 ubiquitin-protein ligase synoviolin	DEG_SPOP_SBC_1	553:557	AASST	SPOP	0.9772	More...
Q8IU81	Interferon regulatory factor 2-binding protein 1	DEG_SPOP_SBC_1	455:459	AASST	SPOP	0.8522	More...
Q8NDV7	Trinucleotide repeat-containing gene 6A protein	DEG_SPOP_SBC_1	1097:1101	AASST	SPOP	0.9707	More...
Q96F05	Uncharacterized protein C11orf24	DEG_SPOP_SBC_1	136:140	AASST	SPOP	0.9889	More...
Q96F05	Uncharacterized protein C11orf24	DEG_SPOP_SBC_1	156:160	AASST	SPOP	0.9963	More...
Q96KP1	Exocyst complex component 2	DEG_SPOP_SBC_1	916:920	AASST	SPOP	0.9073	More...
Q96P47	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3	DEG_SPOP_SBC_1	320:324	AASST	SPOP	0.9988	More...
Q9BTC0	Death-inducer obliterator 1	DEG_SPOP_SBC_1	1299:1303	AASST	SPOP	0.9885	More...
Q9BXT5	Testis-expressed protein 15	DEG_SPOP_SBC_1	1366:1370	AASST	SPOP	0.5082	More...
Q9BYI3	Hyccin	DEG_SPOP_SBC_1	355:359	AASST	SPOP	0.9992	More...
Q9BZZ2	Sialoadhesin	DEG_SPOP_SBC_1	564:568	AASST	SPOP	0.8123	More...
Q9C0A1	Zinc finger homeobox protein 2	DEG_SPOP_SBC_1	43:47	AASST	SPOP	0.9864	More...
Q9HAF1	Chromatin modification-related protein MEAF6	DEG_SPOP_SBC_1	155:159	AASST	SPOP	0.6503	More...
Q9NP87	DNA-directed DNA/RNA polymerase mu	DEG_SPOP_SBC_1	17:21	AASST	SPOP	0.983	More...
Q9UHV7	Mediator of RNA polymerase II transcription subunit 13	DEG_SPOP_SBC_1	1509:1513	AASST	SPOP	0.6304	More...
Q9UIF8	Bromodomain adjacent to zinc finger domain protein 2B	DEG_SPOP_SBC_1	11:15	AASST	SPOP	0.92	More...
Q9UIF8	Bromodomain adjacent to zinc finger domain protein 2B	DEG_SPOP_SBC_1	525:529	AASST	SPOP	0.9018	More...
Q9Y4A8	Nuclear factor erythroid 2-related factor 3	DEG_SPOP_SBC_1	132:136	AASST	SPOP	0.7076	More...
Q9Y2G4	Ankyrin repeat domain-containing protein 6	DEG_SPOP_SBC_1	637:641	AASST	SPOP	0.7804	More...
Q9Y2W3	Proton-associated sugar transporter A	DEG_SPOP_SBC_1	38:42	AASST	SPOP	0.9955	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: AASST

Degron related mutations and impact score

Drug responses associated with TNRC6A mutations

All proteins holding degron of AASST