DegronMD - Q00587(CDC42EP1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R165C	TCGA-66-2792	LUSC	TCGA	DSGFCT	DEG_SCF_TRCP1_1	157:162	Mutation rewiring degron network	0.25
p.R165C	DO26451	LUSC	ICGC	DSGFCT	DEG_SCF_TRCP1_1	157:162	Mutation rewiring degron network	0.25
p.R165S	TCGA-A5-A0G2	UCEC	TCGA	DSGFCT	DEG_SCF_TRCP1_1	157:162	Mutation rewiring degron network	0.25
p.R165S	DO41235	UCEC	ICGC	DSGFCT	DEG_SCF_TRCP1_1	157:162	Mutation rewiring degron network	0.25
p.V134M	TCGA-A8-A09Z	BRCA	TCGA	PTSST	DEG_SPOP_SBC_1	144:148	Mutation rewiring degron network	0.0556
p.V134M	DO5521	BRCA	ICGC	PTSST	DEG_SPOP_SBC_1	144:148	Mutation rewiring degron network	0.0556
p.S147C	TCGA-AC-A5XS	BRCA	TCGA	PTSST	DEG_SPOP_SBC_1	144:148	Mutation altering degron motif	0.7541
p.S147C	DO50023	BRCA	ICGC	PTSST	DEG_SPOP_SBC_1	144:148	Mutation altering degron motif	0.7541
p.P172S	TCGA-EE-A29X	SKCM	TCGA	DSGFCT	DEG_SCF_TRCP1_1	157:162	Mutation rewiring degron network	0.0556
p.P172S	DO222510	MELA	ICGC	DSGFCT	DEG_SCF_TRCP1_1	157:162	Mutation rewiring degron network	0.0556
p.P172S	DO37595	SKCM	ICGC	DSGFCT	DEG_SCF_TRCP1_1	157:162	Mutation rewiring degron network	0.0556
p.P172L	TCGA-VQ-AA6D	STAD	TCGA	DSGFCT	DEG_SCF_TRCP1_1	157:162	Mutation rewiring degron network	0.0556
p.P172L	DO222392	STAD	ICGC	DSGFCT	DEG_SCF_TRCP1_1	157:162	Mutation rewiring degron network	0.0556
p.S169L	DO52511	EOPC	ICGC	DSGFCT	DEG_SCF_TRCP1_1	157:162	Mutation rewiring degron network	0.1389
p.S146I	DO229032	LICA	ICGC	PTSST	DEG_SPOP_SBC_1	144:148	Mutation altering degron motif	0.8453
p.R165L	DO229045	LICA	ICGC	DSGFCT	DEG_SCF_TRCP1_1	157:162	Mutation rewiring degron network	0.25
p.H283N	DO26553	LUSC	ICGC	AASST	DEG_SPOP_SBC_1	277:281	Mutation rewiring degron network	0.2778
p.G289W	DO50729	ORCA	ICGC	AASST	DEG_SPOP_SBC_1	277:281	Mutation rewiring degron network	0.1111
p.S169P	DO33070	PACA	ICGC	DSGFCT	DEG_SCF_TRCP1_1	157:162	Mutation rewiring degron network	0.1389
p.H283Y	DO37782	SKCM	ICGC	AASST	DEG_SPOP_SBC_1	277:281	Mutation rewiring degron network	0.2778
p.R168H	SIDM00588	Oral Cavity Carcinoma	GDSC	DSGFCT	DEG_SCF_TRCP1_1	157:162	Mutation rewiring degron network	0.1667
p.R168H	HSC-4	upper aerodigestive tract	COSMIC	DSGFCT	DEG_SCF_TRCP1_1	157:162	Mutation rewiring degron network	0.1667
p.P273S	SIDM00545	Melanoma	GDSC	AASST	DEG_SPOP_SBC_1	277:281	Mutation rewiring degron network	0.2222
p.P273S	SIDM00003	Melanoma	GDSC	AASST	DEG_SPOP_SBC_1	277:281	Mutation rewiring degron network	0.2222
p.P273S	ACH-000884	Skin Cancer	CCLE	AASST	DEG_SPOP_SBC_1	277:281	Mutation rewiring degron network	0.2222
p.P273S	ACH-000987	Skin Cancer	CCLE	AASST	DEG_SPOP_SBC_1	277:281	Mutation rewiring degron network	0.2222
p.P273S	ACH-002159	Skin Cancer	CCLE	AASST	DEG_SPOP_SBC_1	277:281	Mutation rewiring degron network	0.2222
p.P273S	Mewo	skin	COSMIC	AASST	DEG_SPOP_SBC_1	277:281	Mutation rewiring degron network	0.2222
p.L156M	SIDM00789	Colorectal Carcinoma	GDSC	DSGFCT	DEG_SCF_TRCP1_1	157:162	Mutation rewiring degron network	0.3056
p.L156M	SIDM00789	Colorectal Carcinoma	GDSC	PTSST	DEG_SPOP_SBC_1	144:148	Mutation rewiring degron network	0.1111
p.L156M	ACH-000997	Colon/Colorectal Cancer	CCLE	DSGFCT	DEG_SCF_TRCP1_1	157:162	Mutation rewiring degron network	0.3056
p.L156M	ACH-000997	Colon/Colorectal Cancer	CCLE	PTSST	DEG_SPOP_SBC_1	144:148	Mutation rewiring degron network	0.1111
p.L156M	ACH-001061	Colon/Colorectal Cancer	CCLE	DSGFCT	DEG_SCF_TRCP1_1	157:162	Mutation rewiring degron network	0.3056
p.L156M	ACH-001061	Colon/Colorectal Cancer	CCLE	PTSST	DEG_SPOP_SBC_1	144:148	Mutation rewiring degron network	0.1111
p.L156M	HCT-15	large intestine	COSMIC	DSGFCT	DEG_SCF_TRCP1_1	157:162	Mutation rewiring degron network	0.3056
p.L156M	HCT-15	large intestine	COSMIC	PTSST	DEG_SPOP_SBC_1	144:148	Mutation rewiring degron network	0.1111
p.R165H	SIDM00596	Endometrial Carcinoma	GDSC	DSGFCT	DEG_SCF_TRCP1_1	157:162	Mutation rewiring degron network	0.25
p.R165H	ACH-001517	Endometrial/Uterine Cancer	CCLE	DSGFCT	DEG_SCF_TRCP1_1	157:162	Mutation rewiring degron network	0.25
p.R165H	HEC-1	endometrium	COSMIC	DSGFCT	DEG_SCF_TRCP1_1	157:162	Mutation rewiring degron network	0.25
p.P144A	SIDM00256	Neuroblastoma	GDSC	PTSST	DEG_SPOP_SBC_1	144:148	Mutation altering degron motif	0.6392
p.P144A	ACH-002281	Neuroblastoma	CCLE	PTSST	DEG_SPOP_SBC_1	144:148	Mutation altering degron motif	0.6392
p.P144A	NB14	autonomic ganglia	COSMIC	PTSST	DEG_SPOP_SBC_1	144:148	Mutation altering degron motif	0.6392
p.T267M	ACH-001369	Ovarian Cancer	CCLE	AASST	DEG_SPOP_SBC_1	277:281	Mutation rewiring degron network	0.0556
p.P287L	ACH-001566	Skin Cancer	CCLE	AASST	DEG_SPOP_SBC_1	277:281	Mutation rewiring degron network	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CDC42EP1

UniProt ID: Q00587

Entrez ID: 11135

Protein name: Cdc42 effector protein 1 (Binder of Rho GTPases 5) (Serum protein MSE55)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CDC42EP1 in