DegronMD

Uniprot ID: Q00587

Source protein: Cdc42 effector protein 1

Source gene: CDC42EP1

Class: DEG_SPOP_SBC_1

Location: 144:148

E3 ligase: SPOP

DEGRON score: 0.9968

ASA_SCORE: 76.02

COIL: 0.9386

CONS_SCORE: 0.6431

DSS_SCORE: 0.4324

HELIX: 0.0304

FCONS_SCORE: 0.9727

RIG_SCORE: 0.5709

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S146I	DO229032	LICA	ICGC	PTSST	DEG_SPOP_SBC_1	0.8453
p.S147C	TCGA-AC-A5XS	BRCA	TCGA	PTSST	DEG_SPOP_SBC_1	0.7541
p.S147C	DO50023	BRCA	ICGC	PTSST	DEG_SPOP_SBC_1	0.7541
p.P144A	SIDM00256	Neuroblastoma	GDSC	PTSST	DEG_SPOP_SBC_1	0.6392
p.P144A	ACH-002281	Neuroblastoma	CCLE	PTSST	DEG_SPOP_SBC_1	0.6392
p.P144A	NB14	autonomic_ganglia	COSMIC	PTSST	DEG_SPOP_SBC_1	0.6392
p.L156M	SIDM00789	Colorectal Carcinoma	GDSC	PTSST	DEG_SPOP_SBC_1	0.1111
p.L156M	ACH-000997	Colon/Colorectal Cancer	CCLE	PTSST	DEG_SPOP_SBC_1	0.1111
p.L156M	ACH-001061	Colon/Colorectal Cancer	CCLE	PTSST	DEG_SPOP_SBC_1	0.1111
p.L156M	HCT-15	large_intestine	COSMIC	PTSST	DEG_SPOP_SBC_1	0.1111
p.V134M	TCGA-A8-A09Z	BRCA	TCGA	PTSST	DEG_SPOP_SBC_1	0.0556
p.V134M	DO5521	BRCA	ICGC	PTSST	DEG_SPOP_SBC_1	0.0556

Showing 1 to 12 of 12 entries

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Drug responses associated with CDC42EP1 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of PTSST

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N302	Angiogenic factor with G patch and FHA domains 1	DEG_SPOP_SBC_1	262:266	PTSST	SPOP	0.9756	More...
Q00587	Cdc42 effector protein 1	DEG_SPOP_SBC_1	144:148	PTSST	SPOP	0.9968	More...
Q8WZ74	Cortactin-binding protein 2	DEG_SPOP_SBC_1	394:398	PTSST	SPOP	0.9594	More...
Q8IUR6	CREB3 regulatory factor	DEG_SPOP_SBC_1	207:211	PTSST	SPOP	0.9783	More...
P15336	Cyclic AMP-dependent transcription factor ATF-2	DEG_SPOP_SBC_1	192:196	PTSST	SPOP	0.99	More...
Q96L91	E1A-binding protein p400	DEG_SPOP_SBC_1	699:703	PTSST	SPOP	0.7029	More...
Q9Y613	FH1/FH2 domain-containing protein 1	DEG_SPOP_SBC_1	391:395	PTSST	SPOP	0.8673	More...
Q71F56	Mediator of RNA polymerase II transcription subunit 13-like	DEG_SPOP_SBC_1	2000:2004	PTSST	SPOP	0.8758	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1289:1293	PTSST	SPOP	0.8909	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3040:3044	PTSST	SPOP	0.6013	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	4197:4201	PTSST	SPOP	0.7113	More...
Q9ULH7	Myocardin-related transcription factor B	DEG_SPOP_SBC_1	544:548	PTSST	SPOP	0.9796	More...
Q12830	Nucleosome-remodeling factor subunit BPTF	DEG_SPOP_SBC_1	2061:2065	PTSST	SPOP	0.7841	More...
O14523	Phospholipid transfer protein C2CD2L	DEG_SPOP_SBC_1	418:422	PTSST	SPOP	0.9786	More...
Q2M2H8	Probable maltase-glucoamylase 2	DEG_SPOP_SBC_1	2086:2090	PTSST	SPOP	0.6316	More...
Q6NW40	Repulsive guidance molecule B	DEG_SPOP_SBC_1	126:130	PTSST	SPOP	0.901	More...
Q7Z5J4	Retinoic acid-induced protein 1	DEG_SPOP_SBC_1	217:221	PTSST	SPOP	0.9896	More...
Q9UNA1	Rho GTPase-activating protein 26	DEG_SPOP_SBC_1	688:692	PTSST	SPOP	0.7165	More...
Q5MJ10	Sperm protein associated with the nucleus on the X chromosome N2	DEG_SPOP_SBC_1	4:8	PTSST	SPOP	0.9481	More...
Q5MJ09	Sperm protein associated with the nucleus on the X chromosome N3	DEG_SPOP_SBC_1	4:8	PTSST	SPOP	0.9373	More...
Q5MJ08	Sperm protein associated with the nucleus on the X chromosome N4	DEG_SPOP_SBC_1	4:8	PTSST	SPOP	0.9627	More...
Q5MJ07	Sperm protein associated with the nucleus on the X chromosome N5	DEG_SPOP_SBC_1	4:8	PTSST	SPOP	0.6951	More...
Q6XYQ8	Synaptotagmin-10	DEG_SPOP_SBC_1	165:169	PTSST	SPOP	0.9752	More...
Q7Z2Z1	Treslin	DEG_SPOP_SBC_1	352:356	PTSST	SPOP	0.7312	More...
Q9Y2R2	Tyrosine-protein phosphatase non-receptor type 22	DEG_SPOP_SBC_1	568:572	PTSST	SPOP	0.6888	More...

Showing 1 to 25 of 27 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PTSST

Degron related mutations and impact score

Drug responses associated with CDC42EP1 mutations

All proteins holding degron of PTSST