DegronMD - Q96L91(EP400)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A694V	TCGA-18-3409	LUSC	TCGA	PTSST	DEG_SPOP_SBC_1	699:703	Mutation rewiring degron network	0.1944
p.V2679I	TCGA-24-1845	OV	TCGA	LTTPGGS	DEG_SCF_FBW7_1	2663:2669	Mutation rewiring degron network	0.0556
p.V2276F	TCGA-46-6026	LUSC	TCGA	PPVY	ITCH	2281:2284	Mutation rewiring degron network	0.1944
p.A2285P	TCGA-55-7995	LUAD	TCGA	PPVY	ITCH	2281:2284	Mutation rewiring degron network	0.3056
p.L2718I	TCGA-AA-A00N	COAD	TCGA	LTPVQT	DEG_SCF_FBW7_1	2719:2724	Mutation rewiring degron network	0.3056
p.R2293C	TCGA-AP-A056	UCEC	TCGA	PPVY	ITCH	2281:2284	Mutation blocking ubiquitination signal	0.5278
p.R2293C	TCGA-AX-A0J0	UCEC	TCGA	PPVY	ITCH	2281:2284	Mutation blocking ubiquitination signal	0.5278
p.R2293C	TCGA-BR-8487	STAD	TCGA	PPVY	ITCH	2281:2284	Mutation blocking ubiquitination signal	0.5278
p.R2293C	TCGA-EB-A4XL	SKCM	TCGA	PPVY	ITCH	2281:2284	Mutation blocking ubiquitination signal	0.5278
p.R2293C	TCGA-EE-A3AC	SKCM	TCGA	PPVY	ITCH	2281:2284	Mutation blocking ubiquitination signal	0.5278
p.L2718F	TCGA-AX-A063	UCEC	TCGA	LTPVQT	DEG_SCF_FBW7_1	2719:2724	Mutation rewiring degron network	0.3056
p.R2293H	TCGA-AX-A1CE	UCEC	TCGA	PPVY	ITCH	2281:2284	Mutation blocking ubiquitination signal	0.5278
p.G2272R	TCGA-B5-A3FC	UCEC	TCGA	PPVY	ITCH	2281:2284	Mutation rewiring degron network	0.0833
p.A694T	TCGA-D1-A0ZO	UCEC	TCGA	PTSST	DEG_SPOP_SBC_1	699:703	Mutation rewiring degron network	0.1944
p.A694T	DO41927	UCEC	ICGC	PTSST	DEG_SPOP_SBC_1	699:703	Mutation rewiring degron network	0.1944
p.A694T	SIDM00425	Ovarian Carcinoma	GDSC	PTSST	DEG_SPOP_SBC_1	699:703	Mutation rewiring degron network	0.1944
p.A694T	OVTOKO	ovary	COSMIC	PTSST	DEG_SPOP_SBC_1	699:703	Mutation rewiring degron network	0.1944
p.P2277H	TCGA-D9-A1X3	SKCM	TCGA	PPVY	ITCH	2281:2284	Mutation rewiring degron network	0.2222
p.S2660F	TCGA-D9-A6EC	SKCM	TCGA	LTTPGGS	DEG_SCF_FBW7_1	2663:2669	Mutation rewiring degron network	0.25
p.R705W	TCGA-DD-A3A5	LIHC	TCGA	PTSST	DEG_SPOP_SBC_1	699:703	Mutation rewiring degron network	0.2778
p.R705W	SIDM00349	Esophageal Squamous Cell Carcinoma	GDSC	PTSST	DEG_SPOP_SBC_1	699:703	Mutation rewiring degron network	0.2778
p.R705W	ACH-000318	Esophageal Cancer	CCLE	PTSST	DEG_SPOP_SBC_1	699:703	Mutation rewiring degron network	0.2778
p.R705W	TE-10	oesophagus	COSMIC	PTSST	DEG_SPOP_SBC_1	699:703	Mutation rewiring degron network	0.2778
p.R2284S	TCGA-GN-A26D	SKCM	TCGA	PPVY	ITCH	2281:2284	Mutation altering degron motif	0.7427
p.S693L	TCGA-H7-8501	HNSC	TCGA	PTSST	DEG_SPOP_SBC_1	699:703	Mutation rewiring degron network	0.1667
p.S2140F	TCGA-IB-7651	PAAD	TCGA	LGPHTD	LIG_APCC_ABBA_1	2126:2131	Mutation rewiring degron network	0.0833
p.T2727A	DO49291	ALL	ICGC	LTPVQT	DEG_SCF_FBW7_1	2719:2724	Mutation rewiring degron network	0.25
p.T2727A	DO221285	AML	ICGC	LTPVQT	DEG_SCF_FBW7_1	2719:2724	Mutation rewiring degron network	0.25
p.G2725S	DO773	BLCA	ICGC	LTPVQT	DEG_SCF_FBW7_1	2719:2724	Mutation rewiring degron network	0.3056
p.T697M	DO10060	COAD	ICGC	PTSST	DEG_SPOP_SBC_1	699:703	Mutation rewiring degron network	0.2778
p.T697M	DO43891	UCEC	ICGC	PTSST	DEG_SPOP_SBC_1	699:703	Mutation rewiring degron network	0.2778
p.H2280Y	DO8898	COAD	ICGC	PPVY	ITCH	2281:2284	Mutation rewiring degron network	0.3056
p.L2717I	DO9876	COAD	ICGC	LTPVQT	DEG_SCF_FBW7_1	2719:2724	Mutation rewiring degron network	0.2778
p.S689L	DO234300	ESAD	ICGC	PTSST	DEG_SPOP_SBC_1	699:703	Mutation rewiring degron network	0.0556
p.S689L	DO218840	SKCA	ICGC	PTSST	DEG_SPOP_SBC_1	699:703	Mutation rewiring degron network	0.0556
p.V2660M	DO233941	GACA	ICGC	LTTPGGS	DEG_SCF_FBW7_1	2663:2669	Mutation rewiring degron network	0.25
p.T2713M	DO233902	GACA	ICGC	LTPVQT	DEG_SCF_FBW7_1	2719:2724	Mutation rewiring degron network	0.1667
p.S692L	DO14202	HNSC	ICGC	PTSST	DEG_SPOP_SBC_1	699:703	Mutation rewiring degron network	0.1389
p.I712N	DO20942	KIRP	ICGC	PTSST	DEG_SPOP_SBC_1	699:703	Mutation rewiring degron network	0.0833
p.T2285I	DO231969	LICA	ICGC	PPVY	ITCH	2281:2284	Mutation rewiring degron network	0.3056
p.V2666F	DO228976	LICA	ICGC	LTTPGGS	DEG_SCF_FBW7_1	2663:2669	Mutation altering degron motif	0.7068
p.V701F	DO229018	LICA	ICGC	PTSST	DEG_SPOP_SBC_1	699:703	Mutation altering degron motif	0.7068
p.A2136S	DO229018	LICA	ICGC	LGPHTD	LIG_APCC_ABBA_1	2126:2131	Mutation rewiring degron network	0.1944
p.A2136S	DO229019	LICA	ICGC	LGPHTD	LIG_APCC_ABBA_1	2126:2131	Mutation rewiring degron network	0.1944
p.V2287F	DO229029	LICA	ICGC	PPVY	ITCH	2281:2284	Mutation substituting flanking lysine	0.3611
p.Q707H	DO229035	LICA	ICGC	PTSST	DEG_SPOP_SBC_1	699:703	Mutation rewiring degron network	0.2222
p.Q2271H	DO229035	LICA	ICGC	PPVY	ITCH	2281:2284	Mutation rewiring degron network	0.0556
p.E2124D	DO229009	LICA	ICGC	LGPHTD	LIG_APCC_ABBA_1	2126:2131	Mutation rewiring degron network	0.2778
p.Q2722H	DO23759	LUAD	ICGC	LTPVQT	DEG_SCF_FBW7_1	2719:2724	Mutation altering degron motif	0.7582
p.T2664S	DO45390	LUAD	ICGC	LTTPGGS	DEG_SCF_FBW7_1	2663:2669	Mutation altering degron motif	0.6005
p.A2119S	DO45339	LUAD	ICGC	LGPHTD	LIG_APCC_ABBA_1	2126:2131	Mutation substituting flanking lysine	0.25
p.S690F	DO220877	MELA	ICGC	PTSST	DEG_SPOP_SBC_1	699:703	Mutation rewiring degron network	0.0833
p.S2729F	DO222843	MELA	ICGC	LTPVQT	DEG_SCF_FBW7_1	2719:2724	Mutation rewiring degron network	0.1944
p.R2137Q	DO35442	PACA	ICGC	LGPHTD	LIG_APCC_ABBA_1	2126:2131	Mutation rewiring degron network	0.1667
p.D2291H	DO36419	READ	ICGC	PPVY	ITCH	2281:2284	Mutation rewiring degron network	0.1389
p.W2123R	DO48547	STAD	ICGC	LGPHTD	LIG_APCC_ABBA_1	2126:2131	Mutation rewiring degron network	0.25
p.T2714M	DO38715	STAD	ICGC	LTPVQT	DEG_SCF_FBW7_1	2719:2724	Mutation rewiring degron network	0.1944
p.L2716F	DO231475	THCA	ICGC	LTPVQT	DEG_SCF_FBW7_1	2719:2724	Mutation rewiring degron network	0.25
p.A2275V	DO42023	UCEC	ICGC	PPVY	ITCH	2281:2284	Mutation rewiring degron network	0.1667
p.V2272A	DO43274	UCEC	ICGC	PPVY	ITCH	2281:2284	Mutation rewiring degron network	0.0833
p.P2293H	DO43250	UCEC	ICGC	PPVY	ITCH	2281:2284	Mutation blocking ubiquitination signal	0.5278
p.P2284S	DO41331	UCEC	ICGC	PPVY	ITCH	2281:2284	Mutation altering degron motif	0.6752
p.T2663M	SIDM00958	Chronic Myelogenous Leukemia	GDSC	LTTPGGS	DEG_SCF_FBW7_1	2663:2669	Mutation altering degron motif	0.7423
p.T2663M	SIDM00847	Rhabdomyosarcoma	GDSC	LTTPGGS	DEG_SCF_FBW7_1	2663:2669	Mutation altering degron motif	0.7423
p.T2663M	ACH-000169	Sarcoma	CCLE	LTTPGGS	DEG_SCF_FBW7_1	2663:2669	Mutation altering degron motif	0.7423
p.T2663M	ACH-000920	Leukemia	CCLE	LTTPGGS	DEG_SCF_FBW7_1	2663:2669	Mutation altering degron motif	0.7423
p.T2663M	CML-T1	haematopoietic and lymphoid tissue	COSMIC	LTTPGGS	DEG_SCF_FBW7_1	2663:2669	Mutation altering degron motif	0.7423
p.T2663M	RD	soft tissue	COSMIC	LTTPGGS	DEG_SCF_FBW7_1	2663:2669	Mutation altering degron motif	0.7423
p.R2279Q	SIDM00429	B-Lymphoblastic Leukemia	GDSC	PPVY	ITCH	2281:2284	Mutation rewiring degron network	0.2778
p.R2279Q	ACH-000938	Leukemia	CCLE	PPVY	ITCH	2281:2284	Mutation rewiring degron network	0.2778
p.R2279Q	NALM-6	haematopoietic and lymphoid tissue	COSMIC	PPVY	ITCH	2281:2284	Mutation rewiring degron network	0.2778
p.A2654V	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	LTTPGGS	DEG_SCF_FBW7_1	2663:2669	Mutation rewiring degron network	0.0833
p.V2678M	ACH-000954	Endometrial/Uterine Cancer	CCLE	LTTPGGS	DEG_SCF_FBW7_1	2663:2669	Mutation rewiring degron network	0.0833
p.A2662V	ACH-000997	Colon/Colorectal Cancer	CCLE	LTTPGGS	DEG_SCF_FBW7_1	2663:2669	Mutation rewiring degron network	0.3056
p.A711V	ACH-002287	Colon/Colorectal Cancer	CCLE	PTSST	DEG_SPOP_SBC_1	699:703	Mutation rewiring degron network	0.1111
p.A711V	NCI-H630	large intestine	COSMIC	PTSST	DEG_SPOP_SBC_1	699:703	Mutation rewiring degron network	0.1111
p.P695L	BE-13	haematopoietic and lymphoid tissue	COSMIC	PTSST	DEG_SPOP_SBC_1	699:703	Mutation rewiring degron network	0.2222
p.S704L	IGR-1	skin	COSMIC	PTSST	DEG_SPOP_SBC_1	699:703	Mutation rewiring degron network	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

EP400

UniProt ID: Q96L91

Entrez ID: 57634

Protein name: E1A-binding protein p400 (EC 3.6.4.-) (CAG repeat protein 32) (Domino homolog) (hDomino) (Trinucleotide repeat-containing gene 12 protein) (p400 kDa SWI2/SNF2-related protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for EP400 in