DegronMD

Uniprot ID: Q96L91

Source protein: E1A-binding protein p400

Source gene: EP400

Class: DEG_SCF_FBW7_1

Location: 2719:2724

E3 ligase: FBXW7

DEGRON score: 0.8632

ASA_SCORE: 98.4667

COIL: 0.8825

CONS_SCORE: 0.4371

DSS_SCORE: 0.3235

HELIX: 0.0148

FCONS_SCORE: 1.1676

RIG_SCORE: 0.799

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L2718I	TCGA-AA-A00N	COAD	TCGA	LTPVQT	DEG_SCF_FBW7_1	0.3056
p.L2718F	TCGA-AX-A063	UCEC	TCGA	LTPVQT	DEG_SCF_FBW7_1	0.3056
p.T2727A	DO49291	ALL	ICGC	LTPVQT	DEG_SCF_FBW7_1	0.25
p.T2727A	DO221285	AML	ICGC	LTPVQT	DEG_SCF_FBW7_1	0.25
p.G2725S	DO773	BLCA	ICGC	LTPVQT	DEG_SCF_FBW7_1	0.3056
p.L2717I	DO9876	COAD	ICGC	LTPVQT	DEG_SCF_FBW7_1	0.2778
p.T2713M	DO233902	GACA	ICGC	LTPVQT	DEG_SCF_FBW7_1	0.1667
p.Q2722H	DO23759	LUAD	ICGC	LTPVQT	DEG_SCF_FBW7_1	0.7582
p.S2729F	DO222843	MELA	ICGC	LTPVQT	DEG_SCF_FBW7_1	0.1944
p.T2714M	DO38715	STAD	ICGC	LTPVQT	DEG_SCF_FBW7_1	0.1944
p.L2716F	DO231475	THCA	ICGC	LTPVQT	DEG_SCF_FBW7_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96L91	E1A-binding protein p400	DEG_SCF_FBW7_1	2719:2724	LTPVQT	FBXW7	0.8632	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons