DegronMD

Uniprot ID: Q96L91

Source protein: E1A-binding protein p400

Source gene: EP400

Class: LIG_APCC_ABBA_1

Location: 2126:2131

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9881

ASA_SCORE: 86.05

COIL: 0.826

CONS_SCORE: 0.4099

DSS_SCORE: 0.69

HELIX: 0.1087

FCONS_SCORE: 1.1935

RIG_SCORE: 0.63

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S2140F	TCGA-IB-7651	PAAD	TCGA	LGPHTD	LIG_APCC_ABBA_1	0.0833
p.A2136S	DO229018	LICA	ICGC	LGPHTD	LIG_APCC_ABBA_1	0.1944
p.A2136S	DO229019	LICA	ICGC	LGPHTD	LIG_APCC_ABBA_1	0.1944
p.E2124D	DO229009	LICA	ICGC	LGPHTD	LIG_APCC_ABBA_1	0.2778
p.A2119S	DO45339	LUAD	ICGC	LGPHTD	LIG_APCC_ABBA_1	0.25
p.R2137Q	DO35442	PACA	ICGC	LGPHTD	LIG_APCC_ABBA_1	0.1667
p.W2123R	DO48547	STAD	ICGC	LGPHTD	LIG_APCC_ABBA_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96L91	E1A-binding protein p400	LIG_APCC_ABBA_1	2126:2131	LGPHTD	APC,CDC20,FZR1	0.9881	More...
Q6PCB5	Lysine-specific demethylase RSBN1L	LIG_APCC_ABBA_1	719:724	LGPHTD	APC,CDC20,FZR1	0.7002	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons