DegronMD

Uniprot ID: Q6PCB5

Source protein: Lysine-specific demethylase RSBN1L

Source gene: RSBN1L

Class: LIG_APCC_ABBA_1

Location: 719:724

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7002

ASA_SCORE: 87.7333

COIL: 0.8972

CONS_SCORE: 0.2775

DSS_SCORE: 0.4438

HELIX: 0.0623

FCONS_SCORE: 1.0336

RIG_SCORE: 0.6935

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S734F	TCGA-W3-A828	SKCM	TCGA	LGPHTD	LIG_APCC_ABBA_1	0.5
p.H722D	SIDM00586	Hepatocellular Carcinoma	GDSC	LGPHTD	LIG_APCC_ABBA_1	0.7688
p.H722D	ACH-000475	Liver Cancer	CCLE	LGPHTD	LIG_APCC_ABBA_1	0.7688
p.H722D	huH-1	liver	COSMIC	LGPHTD	LIG_APCC_ABBA_1	0.7688
p.S717P	SIDM00217	Colorectal Carcinoma	GDSC	LGPHTD	LIG_APCC_ABBA_1	0.2778
p.S717P	ACH-000999	Colon/Colorectal Cancer	CCLE	LGPHTD	LIG_APCC_ABBA_1	0.2778
p.S717P	SNU-1040	large_intestine	COSMIC	LGPHTD	LIG_APCC_ABBA_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96L91	E1A-binding protein p400	LIG_APCC_ABBA_1	2126:2131	LGPHTD	APC,CDC20,FZR1	0.9881	More...
Q6PCB5	Lysine-specific demethylase RSBN1L	LIG_APCC_ABBA_1	719:724	LGPHTD	APC,CDC20,FZR1	0.7002	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons