DegronMD - Q6PCB5(RSBN1L)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V229L	TCGA-06-5416	GBM	TCGA	KKENG	DEG_APCC_KENBOX_2	223:227	Mutation rewiring degron network	0.2778
p.V229L	DO10880	GBM	ICGC	KKENG	DEG_APCC_KENBOX_2	223:227	Mutation rewiring degron network	0.2778
p.R560C	TCGA-19-1790	GBM	TCGA	REMLFED	LIG_APCC_ABBAyCdc20_2	560:566	Mutation altering degron motif	0.8301
p.R560C	DO12328	GBM	ICGC	REMLFED	LIG_APCC_ABBAyCdc20_2	560:566	Mutation altering degron motif	0.8301
p.E228G	TCGA-43-8118	LUSC	TCGA	KKENG	DEG_APCC_KENBOX_2	223:227	Mutation rewiring degron network	0.3056
p.E228G	DO45471	LUSC	ICGC	KKENG	DEG_APCC_KENBOX_2	223:227	Mutation rewiring degron network	0.3056
p.R555Q	TCGA-56-8307	LUSC	TCGA	REMLFED	LIG_APCC_ABBAyCdc20_2	560:566	Mutation rewiring degron network	0.1944
p.R555Q	TCGA-AP-A056	UCEC	TCGA	REMLFED	LIG_APCC_ABBAyCdc20_2	560:566	Mutation rewiring degron network	0.1944
p.R555Q	TCGA-B5-A3FA	UCEC	TCGA	REMLFED	LIG_APCC_ABBAyCdc20_2	560:566	Mutation rewiring degron network	0.1944
p.R555Q	DO219139	LUSC	ICGC	REMLFED	LIG_APCC_ABBAyCdc20_2	560:566	Mutation rewiring degron network	0.1944
p.R555Q	DO52402	UCEC	ICGC	REMLFED	LIG_APCC_ABBAyCdc20_2	560:566	Mutation rewiring degron network	0.1944
p.R555Q	DO43971	UCEC	ICGC	REMLFED	LIG_APCC_ABBAyCdc20_2	560:566	Mutation rewiring degron network	0.1944
p.K230N	TCGA-AG-A002	READ	TCGA	KKENG	DEG_APCC_KENBOX_2	223:227	Mutation substituting flanking lysine	0.3611
p.K230N	TCGA-DF-A2KU	UCEC	TCGA	KKENG	DEG_APCC_KENBOX_2	223:227	Mutation substituting flanking lysine	0.3611
p.K230N	DO223286	UCEC	ICGC	KKENG	DEG_APCC_KENBOX_2	223:227	Mutation substituting flanking lysine	0.3611
p.N220H	TCGA-AP-A1DV	UCEC	TCGA	KKENG	DEG_APCC_KENBOX_2	223:227	Mutation rewiring degron network	0.25
p.N220H	DO43186	UCEC	ICGC	KKENG	DEG_APCC_KENBOX_2	223:227	Mutation rewiring degron network	0.25
p.E228K	TCGA-BS-A0UV	UCEC	TCGA	KKENG	DEG_APCC_KENBOX_2	223:227	Mutation rewiring degron network	0.3056
p.E228K	DO42793	UCEC	ICGC	KKENG	DEG_APCC_KENBOX_2	223:227	Mutation rewiring degron network	0.3056
p.H571Y	TCGA-FW-A3R5	SKCM	TCGA	REMLFED	LIG_APCC_ABBAyCdc20_2	560:566	Mutation rewiring degron network	0.1944
p.H571Y	DO37406	SKCM	ICGC	REMLFED	LIG_APCC_ABBAyCdc20_2	560:566	Mutation rewiring degron network	0.1944
p.S734F	TCGA-W3-A828	SKCM	TCGA	LGPHTD	LIG_APCC_ABBA_1	719:724	Mutation blocking phosphorylation signal	0.5
p.T568A	DO222762	COCA	ICGC	REMLFED	LIG_APCC_ABBAyCdc20_2	560:566	Mutation rewiring degron network	0.2778
p.H722D	SIDM00586	Hepatocellular Carcinoma	GDSC	LGPHTD	LIG_APCC_ABBA_1	719:724	Mutation altering degron motif	0.7688
p.H722D	ACH-000475	Liver Cancer	CCLE	LGPHTD	LIG_APCC_ABBA_1	719:724	Mutation altering degron motif	0.7688
p.H722D	huH-1	liver	COSMIC	LGPHTD	LIG_APCC_ABBA_1	719:724	Mutation altering degron motif	0.7688
p.R569T	SIDM00744	Non-Small Cell Lung Carcinoma	GDSC	REMLFED	LIG_APCC_ABBAyCdc20_2	560:566	Mutation rewiring degron network	0.25
p.R569T	ACH-000893	Lung Cancer	CCLE	REMLFED	LIG_APCC_ABBAyCdc20_2	560:566	Mutation rewiring degron network	0.25
p.R569T	NCI-H1651	lung	COSMIC	REMLFED	LIG_APCC_ABBAyCdc20_2	560:566	Mutation rewiring degron network	0.25
p.S717P	SIDM00217	Colorectal Carcinoma	GDSC	LGPHTD	LIG_APCC_ABBA_1	719:724	Mutation rewiring degron network	0.2778
p.S717P	ACH-000999	Colon/Colorectal Cancer	CCLE	LGPHTD	LIG_APCC_ABBA_1	719:724	Mutation rewiring degron network	0.2778
p.S717P	SNU-1040	large intestine	COSMIC	LGPHTD	LIG_APCC_ABBA_1	719:724	Mutation rewiring degron network	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RSBN1L

UniProt ID: Q6PCB5

Entrez ID: 222194

Protein name: Lysine-specific demethylase RSBN1L (EC 1.14.11.-) (Round spermatid basic protein 1-like protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RSBN1L in