DegronMD

Uniprot ID: Q6PCB5

Source protein: Lysine-specific demethylase RSBN1L

Source gene: RSBN1L

Class: DEG_APCC_KENBOX_2

Location: 223:227

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7823

ASA_SCORE: 103.32

COIL: 0.5722

CONS_SCORE: 0.4856

DSS_SCORE: 0.4798

HELIX: 0.391

FCONS_SCORE: 1.0136

RIG_SCORE: 0.7229

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V229L	TCGA-06-5416	GBM	TCGA	KKENG	DEG_APCC_KENBOX_2	0.2778
p.V229L	DO10880	GBM	ICGC	KKENG	DEG_APCC_KENBOX_2	0.2778
p.E228G	TCGA-43-8118	LUSC	TCGA	KKENG	DEG_APCC_KENBOX_2	0.3056
p.E228G	DO45471	LUSC	ICGC	KKENG	DEG_APCC_KENBOX_2	0.3056
p.K230N	TCGA-AG-A002	READ	TCGA	KKENG	DEG_APCC_KENBOX_2	0.3611
p.K230N	TCGA-DF-A2KU	UCEC	TCGA	KKENG	DEG_APCC_KENBOX_2	0.3611
p.K230N	DO223286	UCEC	ICGC	KKENG	DEG_APCC_KENBOX_2	0.3611
p.N220H	TCGA-AP-A1DV	UCEC	TCGA	KKENG	DEG_APCC_KENBOX_2	0.25
p.N220H	DO43186	UCEC	ICGC	KKENG	DEG_APCC_KENBOX_2	0.25
p.E228K	TCGA-BS-A0UV	UCEC	TCGA	KKENG	DEG_APCC_KENBOX_2	0.3056
p.E228K	DO42793	UCEC	ICGC	KKENG	DEG_APCC_KENBOX_2	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q0VDF9	Heat shock 70 kDa protein 14	DEG_APCC_KENBOX_2	468:472	KKENG	APC,CDC20,FZR1	0.8284	More...
Q99741	Cell division control protein 6 homolog	DEG_APCC_KENBOX_2	80:84	KKENG	APC,CDC20,FZR1	0.9805	More...
Q9H788	SH2 domain-containing protein 4A	DEG_APCC_KENBOX_2	59:63	KKENG	APC,CDC20,FZR1	0.5489	More...
Q9Y639	Neuroplastin	DEG_APCC_KENBOX_2	273:277	KKENG	APC,CDC20,FZR1	0.5141	More...
Q6PCB5	Lysine-specific demethylase RSBN1L	DEG_APCC_KENBOX_2	223:227	KKENG	APC,CDC20,FZR1	0.7823	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons