DegronMD

Uniprot ID: Q0VDF9

Source protein: Heat shock 70 kDa protein 14

Source gene: HSPA14

Class: DEG_APCC_KENBOX_2

Location: 468:472

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8284

ASA_SCORE: 76.56

COIL: 0.8066

CONS_SCORE: 0.5207

DSS_SCORE: 0.1697

HELIX: 0.1024

FCONS_SCORE: 0.8426

RIG_SCORE: 0.7888

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R474C	TCGA-AA-3984	COAD	TCGA	KKENG	DEG_APCC_KENBOX_2	0.2778
p.R474C	TCGA-AN-A0AK	BRCA	TCGA	KKENG	DEG_APCC_KENBOX_2	0.2778
p.R474C	DO1608	BRCA	ICGC	KKENG	DEG_APCC_KENBOX_2	0.2778
p.R474C	DO9002	COAD	ICGC	KKENG	DEG_APCC_KENBOX_2	0.2778
p.A459S	TCGA-B5-A11W	UCEC	TCGA	KKENG	DEG_APCC_KENBOX_2	0.0833
p.A459S	DO42264	UCEC	ICGC	KKENG	DEG_APCC_KENBOX_2	0.0833
p.A459V	TCGA-B5-A11W	UCEC	TCGA	KKENG	DEG_APCC_KENBOX_2	0.0833
p.A459V	DO42264	UCEC	ICGC	KKENG	DEG_APCC_KENBOX_2	0.0833
p.E470Q	TCGA-UY-A8OD	BLCA	TCGA	KKENG	DEG_APCC_KENBOX_2	0.6744
p.E470Q	DO219039	BLCA	ICGC	KKENG	DEG_APCC_KENBOX_2	0.6744
p.E470Q	SIDM00401	Melanoma	GDSC	KKENG	DEG_APCC_KENBOX_2	0.6744
p.E470Q	ACH-000614	Skin Cancer	CCLE	KKENG	DEG_APCC_KENBOX_2	0.6744
p.E470Q	ACH-002461	Skin Cancer	CCLE	KKENG	DEG_APCC_KENBOX_2	0.6744
p.E470Q	RVH-421	skin	COSMIC	KKENG	DEG_APCC_KENBOX_2	0.6744
p.A478S	DO229045	LICA	ICGC	KKENG	DEG_APCC_KENBOX_2	0.1667
p.D465N	DO229232	THCA	ICGC	KKENG	DEG_APCC_KENBOX_2	0.25
p.M482L	SIDM00113	Kidney Carcinoma	GDSC	KKENG	DEG_APCC_KENBOX_2	0.0556
p.M482L	ACH-001208	Kidney Cancer	CCLE	KKENG	DEG_APCC_KENBOX_2	0.0556
p.M482L	TK10	kidney	COSMIC	KKENG	DEG_APCC_KENBOX_2	0.0556
p.I476T	SIDM00282	Colorectal Carcinoma	GDSC	KKENG	DEG_APCC_KENBOX_2	0.2222
p.I476T	ACH-000998	Colon/Colorectal Cancer	CCLE	KKENG	DEG_APCC_KENBOX_2	0.2222
p.I476T	CW-2	large_intestine	COSMIC	KKENG	DEG_APCC_KENBOX_2	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q0VDF9	Heat shock 70 kDa protein 14	DEG_APCC_KENBOX_2	468:472	KKENG	APC,CDC20,FZR1	0.8284	More...
Q99741	Cell division control protein 6 homolog	DEG_APCC_KENBOX_2	80:84	KKENG	APC,CDC20,FZR1	0.9805	More...
Q9H788	SH2 domain-containing protein 4A	DEG_APCC_KENBOX_2	59:63	KKENG	APC,CDC20,FZR1	0.5489	More...
Q9Y639	Neuroplastin	DEG_APCC_KENBOX_2	273:277	KKENG	APC,CDC20,FZR1	0.5141	More...
Q6PCB5	Lysine-specific demethylase RSBN1L	DEG_APCC_KENBOX_2	223:227	KKENG	APC,CDC20,FZR1	0.7823	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons