DegronMD

Uniprot ID: Q99741

Source protein: Cell division control protein 6 homolog

Source gene: CDC6

Class: DEG_APCC_KENBOX_2

Location: 80:84

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9805

ASA_SCORE: 115.84

COIL: 0.9428

CONS_SCORE: 0.354

DSS_SCORE: 0.8019

HELIX: 0.0272

FCONS_SCORE: 1.0293

RIG_SCORE: 0.4838

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K80N	TCGA-66-2768	LUSC	TCGA	KKENG	DEG_APCC_KENBOX_2	0.5806
p.K80N	DO27216	LUSC	ICGC	KKENG	DEG_APCC_KENBOX_2	0.5806
p.K92N	TCGA-A5-A1OF	UCEC	TCGA	KKENG	DEG_APCC_KENBOX_2	0.5556
p.K92N	DO42568	UCEC	ICGC	KKENG	DEG_APCC_KENBOX_2	0.5556
p.R94Q	TCGA-EI-6917	READ	TCGA	KKENG	DEG_APCC_KENBOX_2	0.0556
p.R94Q	DO36881	READ	ICGC	KKENG	DEG_APCC_KENBOX_2	0.0556
p.E82Q	TCGA-MP-A4TK	LUAD	TCGA	KKENG	DEG_APCC_KENBOX_2	0.6744
p.E82Q	DO45384	LUAD	ICGC	KKENG	DEG_APCC_KENBOX_2	0.6744
p.H87Q	TCGA-UY-A9PH	BLCA	TCGA	KKENG	DEG_APCC_KENBOX_2	0.25
p.H87Q	DO223594	BLCA	ICGC	KKENG	DEG_APCC_KENBOX_2	0.25
p.H89R	DO233853	GACA	ICGC	KKENG	DEG_APCC_KENBOX_2	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q0VDF9	Heat shock 70 kDa protein 14	DEG_APCC_KENBOX_2	468:472	KKENG	APC,CDC20,FZR1	0.8284	More...
Q99741	Cell division control protein 6 homolog	DEG_APCC_KENBOX_2	80:84	KKENG	APC,CDC20,FZR1	0.9805	More...
Q9H788	SH2 domain-containing protein 4A	DEG_APCC_KENBOX_2	59:63	KKENG	APC,CDC20,FZR1	0.5489	More...
Q9Y639	Neuroplastin	DEG_APCC_KENBOX_2	273:277	KKENG	APC,CDC20,FZR1	0.5141	More...
Q6PCB5	Lysine-specific demethylase RSBN1L	DEG_APCC_KENBOX_2	223:227	KKENG	APC,CDC20,FZR1	0.7823	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons