DegronMD

Uniprot ID: Q9Y639

Source protein: Neuroplastin

Source gene: NPTN

Class: DEG_APCC_KENBOX_2

Location: 273:277

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5141

ASA_SCORE: 93.48

COIL: 0.7988

CONS_SCORE: 0.4758

DSS_SCORE: 0.2997

HELIX: 0.0142

FCONS_SCORE: 0.7789

RIG_SCORE: 0.7935

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D268E	TCGA-28-1746	GBM	TCGA	KKENG	DEG_APCC_KENBOX_2	0.1944
p.D268E	DO13564	GBM	ICGC	KKENG	DEG_APCC_KENBOX_2	0.1944
p.I282V	TCGA-91-A4BD	LUAD	TCGA	KKENG	DEG_APCC_KENBOX_2	0.1944
p.I282V	DO45315	LUAD	ICGC	KKENG	DEG_APCC_KENBOX_2	0.1944
p.R272H	TCGA-BR-8591	STAD	TCGA	KKENG	DEG_APCC_KENBOX_2	0.3056
p.R272H	DO47973	STAD	ICGC	KKENG	DEG_APCC_KENBOX_2	0.3056
p.P267Q	TCGA-EE-A2GO	SKCM	TCGA	KKENG	DEG_APCC_KENBOX_2	0.1667
p.P267Q	DO37823	SKCM	ICGC	KKENG	DEG_APCC_KENBOX_2	0.1667
p.P265R	TCGA-W3-A825	SKCM	TCGA	KKENG	DEG_APCC_KENBOX_2	0.1111
p.P265R	DO51272	SKCM	ICGC	KKENG	DEG_APCC_KENBOX_2	0.1111
p.Q274K	DO229015	LICA	ICGC	KKENG	DEG_APCC_KENBOX_2	0.6944
p.K270T	DO41379	UCEC	ICGC	KKENG	DEG_APCC_KENBOX_2	0.25
p.P279H	SIDM00839	Colorectal Carcinoma	GDSC	KKENG	DEG_APCC_KENBOX_2	0.2778
p.P279H	ACH-000950	Colon/Colorectal Cancer	CCLE	KKENG	DEG_APCC_KENBOX_2	0.2778
p.P279H	LoVo	large_intestine	COSMIC	KKENG	DEG_APCC_KENBOX_2	0.2778
p.N266I	THP-1	haematopoietic_and_lymphoid_tissue	COSMIC	KKENG	DEG_APCC_KENBOX_2	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q0VDF9	Heat shock 70 kDa protein 14	DEG_APCC_KENBOX_2	468:472	KKENG	APC,CDC20,FZR1	0.8284	More...
Q99741	Cell division control protein 6 homolog	DEG_APCC_KENBOX_2	80:84	KKENG	APC,CDC20,FZR1	0.9805	More...
Q9H788	SH2 domain-containing protein 4A	DEG_APCC_KENBOX_2	59:63	KKENG	APC,CDC20,FZR1	0.5489	More...
Q9Y639	Neuroplastin	DEG_APCC_KENBOX_2	273:277	KKENG	APC,CDC20,FZR1	0.5141	More...
Q6PCB5	Lysine-specific demethylase RSBN1L	DEG_APCC_KENBOX_2	223:227	KKENG	APC,CDC20,FZR1	0.7823	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons